Use of murine models of cytokine-secreting tumor vaccines to study feasibility and toxicity issues critical to designing clinical trials.
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Animals↗
Biomedical subjects
C Counts
Publications and source records attributed to C Counts.
ANNA Educational Resource List 1991.
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Education, Nursing, Continuing↗
A controlled trial of naltrexone in obese humans.
Based on reports that opiate antagonists can curtail short-term eating in several species including humans, the efficacy of naltrexone in promoting weight loss by obese subjects was examined. Naltrexone, a long-acting oral opiate antagonist, was studied in a randomized parallel double-blind placebo controlled ten week trial in 27 females and 14 males who were 30-100 percent overweight. Subjects on naltrexone lost an average of 1.8 kg and placebo subjects lost 1.5 kg, with no significant difference between groups. Three subjects who took naltrexone had elevations of liver transaminases, two times higher than normal. In the present study naltrexone at a daily dosage of 200 mg did not appear to have efficacy in producing weight loss after eight weeks of treatment. Studies of the effects of naltrexone at higher dosage or for longer periods should monitor hepatic function.
Adult↗
Comparison of Prenate Advance with other prescription prenatal vitamins: a folic acid dissolution study.
Folic acid is important in the prevention of neural tube defects. This study assessed the folic acid dissolution performance of Prenate Advance and six other commonly prescribed prenatal vitamins and compared the results with the United States Pharmacopeia (USP) standards. Of the seven products tested, only three met the USP standard for folic acid dissolution. At 110% of the labeled amount, the Prenate Advance product had the highest folic acid dissolution level. Average dissolution for the four products failing to meet the USP standard ranged from 0% to 38% of labeled amount. These results corroborate findings from other studies suggesting marked differences in dissolution of prescription prenatal vitamins. These findings raise concerns of whether some women could fail to achieve the recommended folate levels needed in early pregnancy to prevent neural tube defects. Prenate Advance met the USP requirement for folic acid dissolution.
Biological Availability↗