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C Crespi

Publications and source records attributed to C Crespi.

At least 37 records · Page 2Linked to original sources
PubMed1987

An autoantibody profile in primary sclerosing cholangitis.

A high frequency of a variety of autoantibodies has been found in sera from patients with primary sclerosing cholangitis (PSC). The prevalence of all types of autoantibodies in PSC was significantly higher than that in healthy controls and patients with isolated inflammatory bowel disease. The titres of the antibodies were rather elevated, particularly in females, and most of them were IgM. The most frequent type of antinuclear antibody was the 'homogenous' type, which is a marker of many autoimmune diseases. The overall prevalence of the antibody was 35%, whereas in female patients it reached 67%. No correlation was found between autoantibody positivity and any clinical parameter. The present findings support the hypothesis that immunological factors may be relevant in PSC.

Antibodies, Antinuclear↗
PubMed1987

Close association between antibodies to cytoskeletal intermediate filaments, and chronic graft-versus-host disease.

Chronic graft-versus-host disease can mimic various autoimmune disorders, although autoantibodies are rarely detected in the sera of affected patients. Antibodies to cytoskeleton are a frequent finding in patients affected by autoimmune disorders. In all the sera of 16 patients who were submitted to allogeneic bone marrow transplantation, we have found antibodies against cytoskeletal intermediate filaments. Moreover, the titer of such antibodies is quite elevated when compared with those reported in autoimmune disorders. A statistically significant difference between the titers found in patients without and with cGVHD (median 1:40 vs. 1:256, P less than 0.05) has been found. This would suggest that such antibodies might be relevant in monitoring clinical course. Furthermore, since certain cytoskeleton antigens have been shown to be expressed also on cell membrane, antibodies against intermediate filaments might also play a more important role by interfering with such surface structures.

Adolescent↗
PubMed1987

Comparison of various cell types as substrates for the detection of antiactin antibodies in chronic liver disease.

Human cultured fibroblasts and Raji and peripheral blood mononuclear cells have been compared as substrates for the immunofluorescent detection of antiactin microfilament antibodies in sera from chronic liver disease. Raji and mononuclear cells, which exhibit a rich microfilament network, proved to be the most sensitive substrates for this purpose. The clinical relevance of these findings in the diagnosis of "autoimmune" chronic liver disease is discussed.

Actin Cytoskeleton↗
PubMed1986

Vimentin and keratin intermediate filaments expression by K562 leukemic cell line.

The expression of intermediate filaments (IMF) by K562 leukemic cell line has been studied by the use of polyclonal and monoclonal antibodies. These cells exhibited an extremely rich network of IMF reacting with both anti-vimentin and anti-keratin antibodies. Although these results need to be confirmed by different techniques, such as immunoblotting, they suggest the possibility that leukemic cell lines can express different types of IMF similarly to other cultured cells.

Actins↗
PubMed1986

Autoimmunity in chronic liver disease caused by hepatitis delta virus.

Recent evidence shows that chronic liver disease induced by hepatitis delta virus is closely associated with production of autoantibodies. To verify this sera from patients with hepatitis delta virus and from those with hepatitis B virus mediated chronic liver disease were tested for a panel of autoantibodies. Although the traditional non-organ specific autoantibodies were similarly distributed in the two groups, a considerably higher prevalence of IgG basal cell layer antibodies, IgM anti-intermediate filaments, and IgG antimicrotubule antibodies was found. Although these phenomena might be secondary to hepatitis delta virus infection, they might be the serological markers of underlying immune events.

Adolescent↗
PubMed1986

Alopecia areata.

Explore the source record for details and available documents.

Adolescent↗
PubMed1985

Relationship between smooth muscle and cytoskeleton antibodies in neuroblastoma.

The previously reported high prevalence of smooth muscle antibodies in neuroblastoma has been found to be associated with a similarly elevated prevalence of anti-cytoskeleton antibodies. The most relevant finding is related to anti-microfilaments (anti-actin) and anti-microtubules antibodies, which were detected with highly significantly different prevalences when compared with a disease control group (p less than 0.001 and p less than 0.000001, respectively). The correspondence between smooth muscle antibodies and anti-cytoskeleton antibodies is incomplete, and it is more relevant for anti-microfilaments. It is concluded that antigen specificities of smooth muscle antibodies in neuroblastoma are as complex as documented in other diseases. Possible pathogenetic and clinical implications emerging from these data are discussed.

Antibodies↗
PubMed1985

Different course of acute hepatitis B in elderly adults.

A retrospective study on 50 young and 35 aged patients with acute hepatitis B was performed. Clinical and laboratory parameters were evaluated. The most significant results obtained in the aged group when compared with the young were longer hospitalization, less elevated serum glutamic-pyruvic transaminase, serum bilirubin and alkaline phosphatase significantly higher, lower IgM and higher IgA levels. The results indicate that acute hepatitis B in elderly adults is characterized by a milder liver cell necrosis and a hypercholestatic pattern. The possible causes for these features are discussed.

Acute Disease↗
PubMed1985

Antibodies to the cytoskeleton components and other autoantibodies in inflammatory bowel disease.

A high prevalence of antibodies to cytoskeleton components (anti-CYTO) and of anti-smooth muscle (SMA) and antinuclear (ANA) antibodies has been found in inflammatory bowel disease (IBD). In particular, a significant correlation has been documented between anti-CYTO and activity of the disease in ulcerative colitis and anti-fibroblast intermediate filaments (anti-vimentin) antibodies and Crohn's disease. The antibodies are detectable in the three major immunoglobulin classes, including IgA. While titres of anti-CYTO did not exceed 1:40, ANA and SMA were of high titres (up to 1:1,280). Antibodies to epithelial cells intermediate filaments (anti-cytokeratin) were detected only occasionally. The significance of these findings in IBD is discussed.

Adolescent↗
PubMed1983

Evaluation of serum rosette inhibitory factors in chronic liver disease.

Serum rosette inhibitory factors (IF) were detected in 61% of 18 sera from HBsAg negative and in 78% of 14 sera from HBsAg positive chronic active liver disease (CALD) patients, who were not under immunosuppressive treatment. In CALD patients, who were under treatment for at least 6 months, IF were detected in 66% of the HBsAg positive patients and only in 18% of the HBsAg negative ones. After precipitation of the serum gamma-globulins by ammonium sulphate, IF were found in the supernatant only in HBsAg positive sera, while completely disappeared in HBsAg negative ones. A significant correlation between serum IF and factors reacting in immunofluorescence (IFL) with a T enriched preparation of lymphocytes was documented only in HBsAg negative cases. No correlation was found between serum IF and circulating immune complexes (IC) or lymphocytotoxins in any of the sera tested. From all these data it is concluded that serum IF detectable in HBsAg negative CALD cases are probably immunoglobulins. Our data would favour the hypothesis that they are anti-T lymphocytes antibodies, since no correlation was found between serum IF and circulating IC. Similar factors, detectable in HBsAg positive sera, are, at least in part, different. The role of such factors in the modulation of the immune response in CALD patients is discussed.

Adolescent↗
PubMed1980

[2 cases of biliary ileus].

Two cases of gallstone ileus are reported. Treatment of the occlusion and the underlying bilio-digestive fistula should be carried out in one surgery session. Careful preoperative preparation of these patients from the hydric, electrolytic and metabolic viewpoints is the indispensable premise for single session treatment.

Aged↗