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Biomedical subjects

C Cunha

Publications and source records attributed to C Cunha.

26 records · Page 2Linked to original sources
PubMed1993

Prefabricated flaps for the head and neck: a preliminary report.

The authors present some clinical applications of the concept of flap prefabrication. Three cases are described where reconstructions around the head and neck were accomplished. The radial vascular territory of the forearm was selected for prefabrication of structures which were then transferred by microsurgical techniques. In two cases, a sensate flap was used, with nerve repair in the neck.

Adolescent↗
PubMed1990

Endogenous benzodiazepine modulation of memory processes.

The immediate posttraining administration of the GABA antagonist, bicuculline, or of the Cl-channel blockers, picrotoxin or Ro 5-4864, enhances memory. These drugs are effective when injected into the amygdaloid nucleus. Intraamygdala muscimol has an opposite effect. All this suggests that memory is modulated at the posttraining period by GABA-A receptors. The pre-, but not posttraining systemic administration of benzodiazepines hinders, and that of inverse agonists, or of the benzodiazepine antagonist, flumazenil enhances retention of diverse tasks. Flumazenil, at doses lower than those that cause an enhancement, antagonizes the effect of benzodiazepine agonists and inverse agonists. This suggests that memory is modulated during acquisition by endogenous benzodiazepine receptor ligands: possibly the diazepam that was recently discovered in brain. Pretraining intraamygdala muscimol administration depresses memory, at doses several times higher than those that are effective posttraining. Pretraining Ro 5-4864 has no effect. This suggests that the release of endogenous benzodiazepines during training may modulate a GABA-A receptor complex, possibly in the amygdala, making it more sensitive to muscimol or Ro 5-4864 in the immediate posttraining period.

Animals↗
PubMed1990

Cervical lung herniation associated with upper airway obstruction.

We present the case of a 6-year-old boy with reactive airway disease who developed cervical lung herniation resulting in compression of the trachea and audible stridor. This association has never been reported in the pediatric age group, and a review of the literature revealed that lung herniation is a rare condition in the pediatric population. Most patients are asymptomatic. Herniation occurs in the cervical area in approximately one fourth of patients. The diagnosis is usually made by physical examination and confirmed by radiographic studies. Treatment is seldom necessary; most patients require only education and reassurance. Surgical intervention is indicated when respiratory distress, cosmetic concerns, or progressive increase in size occur.

Airway Obstruction↗
PubMed1989

Severe hyperphosphatemia, hypocalcemia, acidosis, and shock in a 5-month-old child following the administration of an adult Fleet enema.

We report the case of a 5-month-old girl who was given an adult Fleet enema by her mother because of her concern that the baby was constipated. Within minutes the child became extremely ill. She developed shock, hyperphosphatemia, hypocalcemia, and acidosis. This case is presented to demonstrate that life-threatening events may result after the injudicious use of enemas in children.

Acidosis↗
PubMed1982

Hyperprolactinaemia and breast disease as evaluated by xeromammography.

This report compares the xeromammographic patterns of 35 patients with hyperprolactinaemia and 70 (age-matched) normoprolactinaemic controls. It is shown that nulliparous patients have less frequent mammary dysplasia and more patterns of involution than the nulliparous controls. The groups of parous patients and parous controls were similar to each other and both had more involutions and less dysplasia than the nulliparous controls. Hyperprolactinaemia in parous women is not associated with any changes in the xeromammographic breast patterns as compared to parous controls. The changes described in hyperprolactinaemic patients can be understood in terms of their low oestrogenic activity.

Adult↗