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Biomedical subjects

C D Barnes

Publications and source records attributed to C D Barnes.

At least 91 records · Page 5Linked to original sources
PubMed1979

Cyclobenzaprine and ethanol interaction.

The effects of cyclobenzaprine, a tricyclic compound, on the central depressant action of ethanol and on hepatic ethanol metabolizing enzymes were studied in rodents. Administration of cyclobenzaprine, 5 mg/kg, IP, 30 min prior to a narcotic dose of ethanol solution, 5 g/kg, IP, enhanced ethanol-produced narcosis in mice. This effect was greater in male than in female mice. Cyclobenzaprine inhibited endogenous rat liver alcohol dehydrogenase in vitro in the concentration range between 10(-5) M and 10(-6)M. Cyclobenzaprine exerted little effect on hepatic aldehyde dehydrogenase in vitro. The results suggest that cyclobenzaprine possesses depressant properties and inhibition of liver alcohol dehydrogenase may underlie the observed behavioral response studied. It is concluded that alteration of endogenous liver alcohol dehydrogenase by certain tricyclic antidepressant drugs may be involved in the mechanism(s) of their toxic interaction with ethanol.

Alcohol Oxidoreductases↗
PubMed1977

Ipsilateral utricular and semicircular canal interactions from electrical stimulation of individual vestibular nerve branches recorded in the descending medial longitudinal fasciculus.

Interactions from electrical stimulation of individual vestibular end organ nerves recorded from second order vestibular neurons projecting caudally in the medial longitudinal fasciculus (MLF) have been investigated in unanesthetized, decerebrate decerebellate cats. Canal-canal and utricle-canal interactions were recorded using various condition-test parameters. The brain stem was sectioned to eliminate influence of the contralateral vestibular nuclei, and the condition-test experiments were repeated. The type of interaction observed (inhibition or facilitation) and the degree to which it occurred were dependent on the MLF recording site. Also, in the case of utricular interactions, these were dependent on the site of utricular stimulation. These dependencies indicate a topological arrangement from receptor cell through the second order neuronal projection pathways. Sectioning of the brain stem produced changes in the interaction patterns, indicating masking and/or balancing of the ipsilateral interactions. In interactions between the anterior and posterior canals, instances of no apparent interaction occurring before sectioning converted to inhibition after sectioning. This indicates that some facilitative interaction occurs involving feedback from the contralateral vestibular nuclei, and this facilitation masks or balances ipsilateral inhibition. In interactions between the anterior and horizontal canals, contralateral inhibitory influence masks ipsilateral facilitatory interactions. Contralateral facilitatory influence again balances ipsilateral inhibition in interactions between the horizontal and posterior canals. The degree of inhibition and facilitation observed indicates that considerably more polysynaptic ipsilateral convergence on second order vestibular neurons occurs than has been demonstrated in intracellular studies. Only inhibition was observed when the anterior canal was conditioned by stimulation of the utricular nerve after sectioning. In all other pairings, mixed effects were observed. It is suggested that this is related to known functional connections of semicircular canal second order neurons with neck motoneurons. Not only is canal output affected by utricular activity, but each canal affects utricular output in a different manner.

Afferent Pathways↗
PubMed1976

A proportional controlled thermoregulator circuit of simple design.

This paper describes a proportional controlled thermoregulator circuit. The instrument controls D.C. current in the heating device, precluding the introduction of radiated interference by the heater. This circuit is capable of regulating the temperature of a typical decerebrated cat to within 0.1 degrees C. A dual channel temperature regulator can be constructed for about $ 300.

Animals↗