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Biomedical subjects

C D Eskelson

Publications and source records attributed to C D Eskelson.

7 recordsLinked to original sources
PubMed1979

The importance of liver in normal and silicotic lung-lipid homeostasis: 3. Triacylglycerols.

Early lung silicosis in rats activates the liver for triacylglycerol (TG) biosynthesis. The newly formed liver TG seems mobilized to the silicotic lung, as indicated by increased lung TG content and specific activity. These TG changes are associated with decreased TG content and increased TG specific activity in the liver. Serum TGs are also decreased at the study times of 6, 24, 72, and 144 h post intrapulmonary silica treatment.

Acute Disease↗
PubMed1978

Identification of ejaculate derived propylamine found in collagen sponge contraceptives.

Propylamine is identified as one of the compounds present in odoriferous intravaginal contraceptive sponges from sexually active women. This compound also appears in samples of human ejaculate incubated at 37 degrees C for seven days. We have identified propylamine by gas liquid chromatography, mass spectroscopy and as N-propylbenzoylamide. Evidently the compound forms enzymatically from spermine and spermidine. We believe that this is the first time that propylamine has been identified as forming from human tissue.

Collagen↗
PubMed1976

Early changes in the arterial wall of chickens fed a cholesterol diet.

A total of 160 1-2 day old chickens were fed a 2% cholesterol diet for a period of 8 to 42 days and compared with an equal number of controls. Aortas were analyzed for various indexes of reactivity of connective tissue, cholesterol content and scanning electron microscopy (SEM) characteristics of the endothelial lining. Cholesterol feeding for a period up to 6 weeks resulted in doubling the level of serum cholesterol. It was, however, without effect on the activity of prolyl hydroxylase, lysyl oxidase, collagenase and collagen content in the aortic wall. As early as 3 weeks of feeding significant changes occurred in total and esterified cholesterol content. At the same time endothelial cells were characteristically contracted with several long cytoplasmic elongations and protrusions. A significant decrease of activity of the above enzymes was found in aortic tissue with increased age of the chicken. Collagen content in aortas increased with age of chickens. It is concluded that cholesterol as an atherogenic agent induces marked changes in endothelial cells and lipids of chicken aorta at earlier periods, prior to the activation of connective tissue.

Animals↗
PubMedDate not supplied

Early changes in the chemical composition of the rat lung after silica administration.

A group of 200 g male Sprague-Dawley rats was injected with 75 mg of quartz (less than 5 mu particle size) and changes in lung DNA, noncollagenous protein, total lipids, and collagen were studied after 6, 24, 72, 96, and 144 hr. Another group of rats received 10, 30, 59, and 75 mg quartz and the above lung analysis was performed 6 days later. Control rats received saline only. Both sets of experiments indicate that striking changes in the above parameters occur very early. The sequence of statistically significant changes was: lung weight (24 hr), DNA (24 hr), noncollagenous proteins (72 hr), total lipids (72 hr), collagen (144 hr). At the dose of 30 mg quartz/lung all the above parameters were significantly increased within 6 days after the lung injury. It is proposed that in early stages of experimental silicosis an excessive amount of collagen accumulates in the lung. Later, some of the deposited collagen is resorbed. This indicates that in the course of the silicotic fibroproliferative inflammation, the balance between collagen deposition and degradation varies.

Animals↗