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Biomedical subjects

C D Farrell

Publications and source records attributed to C D Farrell.

10 recordsLinked to original sources
PubMed1997

Locus heterogeneity, anticipation and reduction of the chromosome 2p minimal candidate region in autosomal dominant familial spastic paraplegia.

We examined 11 Caucasian pedigrees with autosomal dominant 'uncomplicated' familial spastic paraplegia (SPG) for linkage to the previously identified loci on chromosomes 2p, 14q and 15q. Chromosome 15q was excluded for all families. Five families showed evidence for linkage to chromosome 2p, one to chromosome 14q, and five families remained indeterminate. Homogeneity analysis of combined chromosome 2p and 14q data gave no evidence for a fourth as yet unidentified SPG locus. Recombination events reduced the chromosome 2p minimum candidate region (MCR) to a 3 cM interval between D2S352 and D2S367 and supported the previously reported 7 cM MCR for chromosome 14q. Age of onset (AO) was highly variable, indicating that subtypes of SPG are more appropriately defined on a genetic basis than by AO. Comparison of AO in parent-child pairs was suggestive of anticipation, with a median difference of 9.0 years (p<0.0001).

Adolescent↗
PubMed1978

Implant of articular eminence for recurrent dislocation of the temporomandibular joint.

Hypermobility of the temporomandibular joint is often caused by trauma, by opening the mouth too wide, by having a mouth forced open during general anesthesia procedures, or by dental procedures. The capsule may be stretched to an extent that dislocation occurs more easily thereafter. An implant of Vitallium mesh attached to the zygoma to restrict anterior movement of the condyle is used to prevent recurrent dislocation of the temporomandibular joint.

Dental Implantation↗
PubMed1977

Evaluation of the surgical stability of 20 cases of inverted-L and C osteotomies.

Twenty cases of inverted-L and C osteotomies were analyzed retrospectively to evaluate the stability of the surgical results. The incidence and degree of relapse are reported for each procedure. Possible compensatory mechanisms, which may be active in counteracting the skeletal relapse observed, are discussed. Several methods of compensating for the anticipated relapse are described. Since tabulation of the original data, 12 of the 20 patients have been followed up for an additional 6 to 12 months. Seven patients had been treated with the inverted-L osteotomy. In these patients, there was an additional 4% loss of the amount of correction in anterior facial height and 8% loss in posterior facial height. Five patients were in the C osteotomy group. An additional 3% of the initial advancement was lost in this interval. Significant occlusal changes were not observed in any of the cases and the skeletal results were still acceptable.

Adolescent↗
PubMed1976

One-stage interpositional bone grafting and vestibuloplasty of the atrophic maxilla.

A technique of one-stage autogenous bone grafting and submucous vestibuloplasty for reconstruction of the atrophic maxillary alveolar ridge has been presented. The advantages are described. Use of this procedure has currently been limited; however, initial success indicates this may be a valuable technique for use in the atrophic maxilla.

Adult↗