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Biomedical subjects

C D Hill

Publications and source records attributed to C D Hill.

27 records · Page 2Linked to original sources
PubMed1981

In vitro comparison of dibekacin and gentamicin activities.

Dibekacin, a new parenteral aminoglycoside, was compared with gentamicin in vitro against 221 clinical isolates. Tests for minimum inhibitory concentrations, performed in agar, demonstrated that dibekacin was comparable to gentamicin against most isolates tested. Dibekacin was slightly more active than gentamicin against some isolates of Pseudomonas aeruginosa, but was significantly less active against strains of Serratia.

Anti-Bacterial Agents↗
PubMed1980

Vestibular inputs to the fastigial nucleus; evidence of convergence of macular and ampullar inputs.

1. Experiments have been undertaken on 11 decerebrate cats to investigate the effects of natural vestibular stimulation on the activity of cerebellar fastigial neurons. 2. From recordings in the rostral portion of the nucleus during sinusoidal lateral (roll) and horizontal (yaw) rotation, distinctive patterns of response were observed. 3. The majority of neurons sensitive to vestibular stimulation showed responses to a single modality of vestibular activation. During lateral tilt some neurones showed positional sensititivy, others gave responses related tothe velocity of movement. Other neurones responded in phase with the velocity of movement in the horizontal plane. 4. Aside from these neuronal responses, others provided indications of a convergence of inputs from different sets of vestibular receptors. In particular, several neurons showed a pattern of response that indicated tht they received inputs from otolith receptors and ampullar receptors of the vertical canal. At low velocities of movement their response was positional but with inreasing velocity the magnitude of the response increased and there was a marked phase shift of the discharge towards head velocity. 5. Neurons responding to horizontal rotation often showed positional responses during lateral tilt. There were also indications of a convergence of ampullar inputs from both vertical and horizontal canals. 6. The neural pathways mediating these resonses are discussed in consideration of previous neuroanatomical and neurophysiological data. We consider it likely that several pathways may act to evoke the patterns of response observed, and a role of the cerebellar cortex is indicated.

Acoustic Maculae↗
PubMedDate not supplied

Cognitive impairment in late-life depression: clinical correlates and treatment implications.

Elderly depressed inpatients with high vs. low scores on a quantitative mental status examination (the Mini-Mental State (MMS)) were compared with regard to demographic and clinical characteristics, treatment and short-term response, and functional status at 2-year follow-up. Low-MMS patients were less well educated and more likely to be delusional, anxious, and globally impaired than high-MMS patients. The two groups responded equally well to treatment, but the low-MMS group required a lengthier hospital stay and greater use of neuroleptic medications. The two groups also had similar long-term outcomes, although greater attrition was observed among cognitively impaired subjects.

Aged↗