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Biomedical subjects

C D Kelley

Publications and source records attributed to C D Kelley.

5 recordsLinked to original sources
PubMed1989

Effects of chronic LHRH-a + 17-methyltestosterone or LHRH-a + testosterone therapy on oocyte growth in the striped mullet (Mugil cephalus).

The striped mullet (Mugil cephalus) exhibits a restricted spawning season and matures only once per spawning cycle. In vivo monitoring of ovarian maturation of individual females during the season reveals that timing of full maturity varies. A small percentage of females that mature early can be induced to spawn and will remature. Such females can be spawned a second time within the same season. Chronic administration of luteinizing hormone-releasing analog (LHRH-a) + testosterone results in accelerated egg growth. The majority of females undergoing this therapy mature at least a month before control fish. When these females are induced to spawn, a higher percentage remature and can be spawned again. The double spawnings of both control and LHRH-a + testosterone-treated females occur without any appreciable loss in egg quality. Administration of LHRH-a + 17 alpha-methyltestosterone essentially inhibits egg growth. Steroid profiles from females undergoing this therapy exhibit a significant drop in circulating testosterone and estradiol 17 beta, compared to control and LHRH-a + testosterone-treated females. Hypotheses for the poor performance of this therapy are discussed.

Animals↗
PubMed1980

Radiation therapy of penile cancer: six to ten-year follow-up.

Ten patients with penile cancer were treated with radiation therapy between 1968 and 1973. Nine of ten remain free of disease though in 1 patient a new penile primary developed eight years after the radiation therapy and was treated by partial penectomy. One patient died following surgery for "bleeding ulcer." He was free of penile cancer five years after radiation. The most common complication is urethral stricture and skin telangiectasia.

Follow-Up Studies↗
PubMed1978

Radiation therapy in lymphomatoid granulomatosis.

Two female patients with lymphomatoid granulomatosis have received radiation therapy for local, progressive, symptomatic lesions. One patient was a 56-year-old woman with concomitant brain and pulmonary lesions which progressed on cyclophosphamide and prednisone therapy. The second patient was a 62-year-old woman with a supraorbital mass which appeared and progressed on prednisone therapy. Both patients exhibited rapid response to radiation therapy, in terms of relief of symptoms and objective evidence of subsidence of local disease. A discussion of the nature of lymphomatoid granulomatosis and its treatment is presented with a review of the literature. One hundred sixty-five cases have now been described including the two in this study, and in only one previous case was radiation therapy utilized to treat local disease, prior to the two cases described herein.

Cyclophosphamide↗