Biomedical subjects
Publications and source records attributed to C D Moore.
Fifteen patients with closed fractures of the distal tibia and fibula had marked elevation of initial compartment pressures. The pressures remained elevated for five days in the ten patients treated by cast and elevation. The pressures returned to normal within 24 hours in the five patients placed in a prototype water-jacketed boot which provides cooling and intermittent compression. Some patients exhibited arteriographic evidence of vascular injury.
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A new tool for analyzing compound libraries by NMR has been developed. Aliquots of solution-state samples (between 120 and 350 microL) are directly injected, using a standard liquids handler, into an NMR (LC-NMR) flow probe. Automated NMR software tracks--and suppresses--intense signals arising from the nondeuterated solvents used (if any) and acquires high-sensitivity one-dimensional 1H NMR spectra. An 88-member combinatorial library, dissolved in DMSO and stored in a 96-well microtiter plate, has been analyzed a number of ways using this technique. This nondestructive technique, which we call direct-injection NMR (DI-NMR) and which is embodied in our versatile automated sample changer (VAST) hardware, has proven to be both routine and robust. Our success in automatically acquiring the NMR data for entire plates of library compounds (within 4-8 h) has caused us to develop new ways to display and analyze the resulting NMR data, as will be shown here.
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