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Biomedical subjects

C D Olinici

Publications and source records attributed to C D Olinici.

At least 19 recordsLinked to original sources
PubMed1988

Cytometric study of carcinoid tumors and their metastases.

A series of 5 lung and 11 gastro-entero-pancreatic carcinoid tumors has been studied microspectrophotometrically. All lung carcinoids and the majority of gut-derived tumors had near-diploid stemlines. The DNA absorption profile of metastases was similar to that of primary tumors. There was no difference in DNA patterns of tumors with and without metastases and it is suggested that cytophotometry cannot predict the metastasizing capacity of carcinoid tumors.

Appendiceal Neoplasms↗
PubMed1978

Different cell clones in bone marrow and spleen of a patient with chronic myelocytic leukemia (CML) in blastic phase.

The chromosome study of a patient with chronic myelocytic leukemia in blastic phase revealed a 46,XY,Ph1/47,XY,Ph1,+8 cytogenetic constitution in bone marrow cells and a 46,XY,Ph1/48,XY,2Ph1,+19 cytogenetic constitution in spleen cells. As the cell clones exhibiting chromosome abnormalities in addition to the Ph1 chromosome evolved apparently independently, it is suggested that the acute transformation had a bifocal, myeloid and splenic origin.

Adult↗
PubMed1978

Clustering of mitoses in human cervical carcinoma.

Mitotic nests have been noted both in tissue culture (Cone, 1968) and in human skin (Rowe and Dixon, 1975). The present paper is concerned with the disposition of mitoses in human tumor tissue. Mitotic indices, cell counts, and mitotic clusters were recorded in 20 carcinomas of the cervix uteri. The significance of the results was verified statistically. In 18 of 20 biopsies, the clustering of mitoses was in excess of chance at the 95% confidence level. Assuming a chance distribution, one would expect only one case (5% of 20 cases) to show significant clustering of mitoses. The incidence of cases which show mitotic clustering is higher in cervical carcinoma than in normal skin and uninvolved skin of psoriatic patients. The clustering phenomenon might be due to an initiating factor derived from a mitotic cell which propagates to other cells and activates them, or to a local deficiency in inhibitor factors which reversibly inhibit mitoses under normal conditions.

Carcinoma, Squamous Cell↗
PubMed1978

Missing X chromosome and ring chromosome 21 in a case of acute myelomonocytic leukemia.

The karyotypic picture of a female patient with acute myelomonocytic leukemia (A.M.M.L.) consisted in the loss of a sex chromosome and a ring chromosome 21. It is suggested that in A.M.M.L. the loss of sex chromosome may represent an early event, the monosomic cells being the object of further chromosome rearrangements, which involve more frequently a chromosome 21.

Adult↗
PubMed1976

Constitutive heterochromatin in Ehrlich ascites carcinoma cells.

The study of the distribution of constitutive heterochromatin in the chromosomes of Ehrlich ascites carcinoma cells has revealed changes in both the amount and the spatial distribution of this class of DNA. The marker chromosomes were identified and the probable mechanism of their formation was discussed.

Animals↗
PubMed1976

Diagnostic value of chromosome examination in effusions from cancer patients.

Fifty nine effusions (6 from patients with benign diseases and 53 from cancer patients) were examined cytologically and cytogenetically. Only diploid cells were observed in the benign effusions. The majority of malignant effusions had chromosomal changes, but in three cases where cytologic examination had revealed the presence of malignant cells, only diploid metaphases were found. No false positive diagnoses were made either by the cytologic or by the cytogenetic technique. The concomitant use of cytologic and cytogenetic examinations has substantially improved the correctness of the diagnosis. If by cytologic examination 43 of the 53 effusions from cancer patients were diagnosed as positive, 4 as suspicious and 6 as negative, the combined results of the cytologic and cytogenetic examination can be summarized in 49 positive, 1 suspicious and 3 negative cases. The implications of these data for the medical practice are briefly discussed.

Breast Neoplasms↗
PubMed1975

Cytogenetic evolution of Ehrlich ascites tumor in rats. A chromosome-banding study.

The injection of Ehrlich tumor cells into normal and immunosuppressed rats induced a transitory ascitic tumor. In an initial stage only Ehrlich metaphases were observed. The incidence of rat metaphases, which appeared later on, increased gradually reaching 100% in a stage when neither the viability nor the tumorigenicity of the Ehrlich cells were significantly modified. No mouse-rat hybrid cells were observed. The results suggest that cell hybridization may be essential for the "naturalization" of a heterologous tumor.

Animals↗