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Biomedical subjects

C D Sooy

Publications and source records attributed to C D Sooy.

13 recordsLinked to original sources
PubMed1992

Ultrasonography of cystic parotid lesions in HIV infection. Similarity of sonographic appearance with Sjögren's syndrome.

Bilateral cystic parotid glands occur in some cases of human immunodeficiency virus (HIV) infection. This abnormality, which is associated with cervical adenopathy, can be defined by sonography in the superficial gland, as noted in three men. In retrospect, this parotid disease has similarity to the sonographic finding of Sjögren's syndrome, except for the finding of cervical adenopathy, an observation not previously appreciated.

Adult↗
PubMed1990

Elevated serum concentrations of IgE antibodies to environmental antigens in HIV-seropositive male homosexuals.

Forty-five homosexual male subjects with human immunodeficiency virus (HIV) infection, who received care during a 4-month period in an ambulatory center for acquired immunodeficiency syndrome (AIDS), were classified according to their principal presentation with characteristic secondary infections (CDC group IV C, N = 28), cancers (IV D, N = 10), or limited or no symptoms (groups II, III, IV A, or IV B, N = 7). The incidence of allergic rhinitis and conjunctivitis increased after HIV seroconversion by approximately twofold in patients of groups IV C and IV D. The mean serum concentration of IgE was significantly higher for group IV C than for the other HIV-seropositive groups and for a control group of 45 HIV-seronegative homosexual male subjects from the same community who were studied concurrently. More patients in groups IV C and IV D had positive RASTs for a panel of environmental antigens than patients in the other HIV-seropositive groups and the HIV-seronegative control group. Patients with AIDS presenting with typical secondary infections thus have a high frequency of some clinical and laboratory manifestations of allergic diseases.

AIDS-Related Complex↗
PubMed1988

Human monoclonal antibody directed against gag gene products of the human immunodeficiency virus.

Tonsillar B lymphocytes from an asymptomatic individual infected with HIV were transformed with EBV. A cloned lymphoblastoid cell line was obtained that secreted human mAb (IgG4 subtype) against the known gag gene products of 55,000 and 25,000 Da and a protein of 40,000 Da. The latter p40 protein appears to be a HIV gag-related gene product that is also recognized immunologically by individuals infected by HIV. Although the mAb detects infection of cells by different HIV isolates, it does not neutralize HIV or show activity in an antibody-dependent cytotoxicity assay.

Antibodies, Monoclonal↗
PubMed1988

Lesions of the head and neck in patients with AIDS: CT and MR findings.

The CT and/or MR findings were reviewed in 43 patients with head and neck disease; 27 had AIDS, 14 had AIDS-related complex, and two had positive human immunodeficiency virus serologies. Fourteen patients had infections, 15 had tumors, and 15 had benign lymphoid hyperplasia. Deep cervical infections were caused by bacterial and mycobacterial organisms, including Mycobacterium avium-intracellulare. Bacterial infections were clinically more virulent than they would be in immunocompetent patients. Neoplasms included Kaposi sarcoma, lymphoma, and squamous cell carcinoma. Benign lymphoid hyperplasia demonstrated enlargement of the cervical lymph nodes, adenoids, and tonsils. Although there was considerable overlap in the imaging characteristics of the various diseases seen, several distinguishing features were noted. Cellulitis, with infiltration and thickening of the subcutaneous fat, was typical of bacterial infections, but was uncommon with tumors or mycobacterial infections. Lymph nodes with necrotic centers were seen with Kaposi sarcoma, squamous cell carcinoma, and mycobacterial infection, but not with lymphoma or benign lymphoid hyperplasia. Benign adenoidal enlargement is usually symmetric with a flat anterior border, but bulky lesions indistinguishable from tumor were seen in two patients. It is important for radiologists to be aware of the spectrum of head and neck disease in patients with human immunodeficiency virus. The CT and MR assessment can guide biopsy and assist in planning therapy.

AIDS-Related Complex↗
PubMed1987

Pyoderma gangrenosum of the oral cavity, nose, and larynx.

Pyoderma gangrenosum is a clinical condition often associated with internal disorders and immunologic abnormalities. The diagnosis is deduced solely from clinical examination because no histologic or laboratory changes are pathognomonic. The lesions are quite painful and can be particularly disabling. Laryngeal involvement should elicit concerns for protection of the airway. This case demonstrated involvement of the oral cavity, nose, and larynx--as well as other skin sites of the body--with pyoderma gangrenosum. To our knowledge, this is the first reported case of intranasal and laryngeal pyoderma gangrenosum. Early treatment of any associated internal disorders and aggressive treatment with corticosteroids usually result in adequate control of this problem.

Biopsy↗
PubMed1987

The risk for otolaryngologists who treat patients with AIDS and AIDS virus infection: report of an in-process study.

The risk of contracting acquired immune deficiency syndrome (AIDS) is a concern to otolaryngologists and other health care workers. Failure to appreciate this valid concern is dangerous, but overestimating it may be equally injurious to the delivery of good patient care. We review the data on antibody titers and recovery of cultured virus in blood, saliva, middle ear fluid, cerumen, tears, and nasal mucous. We also report the initial findings of a prospective study of otolaryngologists at the San Francisco General Hospital. It appears that the risk of transmission of AIDS is low and can be minimized by sound infection control measures similar to those for hepatitis B.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Pharyngeal Kaposi's sarcoma in patients with AIDS.

The radiographic appearance of gastrointestinal Kaposi's sarcoma in patients with AIDS has been described previously, but little attention has been paid to pharyngeal involvement. This study compared the radiographic findings of pharyngeal Kaposi's sarcoma in eight patients with AIDS and dysphagia to those of visual inspection by laryngoscopy or bronchoscopy. Barium pharyngography (six patients) demonstrated nodular lesions without ulceration, ranging in extent from a single nodule to extensive confluent disease. CT (two patients) showed nodular or polypoid intraluminal protrusions, distortion of valleculae and pyriform sinuses, infiltration of deep-tissue planes, and adenopathy. A 4-mm nodular lesion was not seen on pharyngography. Radiographic evaluation provided supplemental information in six patients, especially regarding inferior extent of disease in four whose bulky lesions precluded adequate visual assessment. CT aided in defining deep-tissue-plane involvement and extent of nodal disease. It is concluded that barium pharyngography and CT are useful in the diagnostic evaluation of possible Kaposi's sarcoma in patients with AIDS and dysphagia.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Otolaryngologic and head and neck manifestations of acquired immunodeficiency syndrome (AIDS).

Patients with acquired immune deficiency syndrome (AIDS) frequently present with signs and symptoms referable to the head and neck. Three hundred ninety-nine patients with AIDS presented at the University of California, San Francisco and its affiliated hospitals from 1980 to April 1984. One hundred sixty-five patients (41%) with AIDS presented with, or had on initial evaluation, head and neck manifestations. Of that group, 58 (35%) had cutaneous, oral, and pharyngeal lesions of Kaposi's sarcoma; 51 (31%) had oral, pharyngeal, esophageal, or laryngeal candidiasis; 36 (22%) had chronic cough and shortness of breath; 13 (8%) had rapidly enlarging neck masses; and 7 (4%) had herpes simplex lesions. With the increasing number of cases of AIDS it is important for the otolaryngologist to be aware of these presentations.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Transcanal management of benign middle ear lesions involving the anterior middle ear cleft.

The anterior middle ear has always been a difficult area to visualize and access. This report reviews the experience with a new approach to gain exposure of the middle ear. This technique involves separating the entire pars flaccida from the handle of the malleus for better exposure and then replacing the drum. Four patients were treated in this fashion; one glomus tympanicum, two congenital cholesteatomas, and one benign adenoma. All patients benefited from improved exposure and resection. No patients had postoperative laterialization of the drum and hearing was maintained.

Adenoma↗
PubMed1984

Endoscopic laser repair of posterior glottic, subglottic and tracheal stenosis by division or micro-trapdoor flap.

Laryngeal and tracheal stenosis have been refractory to a wide variety of treatments including dilation, stents, or have required major open operation, e.g., laryngofissure with and without skin or mucosal grafts and segmental resection with larynx release. Adequate airway even when achieved was frequently at the expense of voice quality and significant morbidity or mortality. A new highly successful endoscopic technique is described for the treatment of posterior glottic stenosis (apparent bilateral vocal cord paralysis), subglottic stenosis, and tracheal stenosis up to 1 cm thick. The procedure involves the endoscopic use of the CO2 laser, and a micro-trapdoor mucosal flap. Ninety percent of the patients in the group studied obtained an adequate airway with good voice quality and no tracheotomy was required in those patients not already having one. In 19 patients there was no mortality and essentially no morbidity.

Adolescent↗