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Biomedical subjects

C D Verwoerd

Publications and source records attributed to C D Verwoerd.

At least 55 records · Page 3Linked to original sources
PubMed1989

Metastatic neck disease. Palpation vs ultrasound examination.

Nodal disease is a diagnostic problem in head and neck oncology. Current methods for investigation of the neck are not satisfactory as far as differentiation between necks with positive nodes and those with negative nodes is concerned. In the present study, the results of palpation and ultrasound examination were compared with histopathologic examination results of 120 neck dissection specimens. Furthermore, the value of ultrasound examination, combined with cytologic examination, of neck nodes was evaluated. Ultrasound examination was characterized by high sensitivity, ie, 96.8%; specificity was 32.0%. When the results of ultrasound-guided fine-needle aspiration biopsy were added to the ultrasound findings, specificity was as high as 92.9%. From these results, it was concluded that ultrasound examination with fine-needle aspiration biopsy is an accurate method for assessment of the neck in head and neck oncology.

Biopsy, Needle↗
PubMed1988

Differential effects of endolaryngeal trauma upon the growth of the subglottis.

In young rabbits (4-week-old) the growth of the subglottis was studied after an endolaryngeal soft tissue trauma. The injury induced the formation of a subglottic stenosis. In contrast to earlier observations on endolaryngeal trauma extending into the cricoid cartilage, the cricoid developed normally to the adult size and shape at 24 weeks. Similar to the earlier findings, the subepithelial layer showed considerable thickening as the result of formation of scar tissue, ectopic cartilage and fatty tissue with interruption of the elastic tunica (= conus elasticus). It was concluded that after endolaryngeal trauma in rabbits two types of subglottic stenosis can develop, determined by the depth of the injury.

Animals↗
PubMed1988

Morphometric study of the growth of the subglottis after interruption of the circular structure of the cricoid.

In young rabbits the growth of the subglottis was studied over a period of 20 weeks after interruption of the circularity of the cricoid on the ventral side. In all cases the cricoid developed into a U-like structure which did not cause an airway narrowing. However, a cricoid lesion combined with an injury to the soft tissue lining led up to a subglottic stenosis. It was concluded that when the soft tissue layer is undamaged, an intact circular structure of the cricoid is not compulsory for the normal development of the subglottis.

Animals↗
PubMed1988

Histologic study of the growth of the subglottis after interruption of the circular structure of the cricoid.

In a previous study in growing rabbits it was demonstrated that after resection of a ventral part of the cricoid the lumen of the subglottic airway developed normal size during further growth up to the adult stage. Histologic investigations of these cases suggest that a subepithelial network of elastic fibres, ventrally suspended to the thyroid and the tracheal rings, ensures the airway lumen and prevents the development of a subglottic stenosis. Resection of a ventral part of the cricoid including the adjacent soft tissue lining of the airway causes an irreversible loss of the supporting elastic layer and the formation of scar tissue resulting in a stenosis. It was concluded that the larynx and trachea can be considered as an inner, elastic tube (= conus elasticus) lined with epithelium, suspended to an outer, segmented cartilaginous tube. At the level of the subglottis an intact conus elasticus is of more importance for the normal development of the airway lumen in young rabbits than an intact ventral half of the cricoid ring.

Animals↗
PubMed1988

The nasal septal cartilage in the newborn.

The largest part of the nasal septum in young children is cartilaginous. It was established that the cartilaginous septum shows a specific pattern of regional differences in thickness and histologic differentiation. The possible meaning of those phenomenons for growth and support are discussed.

Cartilage↗
PubMed1988

Reimplantation of autologous septal cartilage in the growing nasal septum. II. The influence of reimplantation of rotated or crushed autologous septal cartilage on nasal growth: an experimental study in growing rabbits.

A series of experiments were carried out on growing rabbits to investigate the effect of rotation (through 90 degrees and 180 degrees) or crushing of autologous cartilage implants on growth of the nose. Reconstruction of the nasal septum with rotated or crushed implants did not restore the normal growth of the nose. This is in accordance with the results of a previously described experiment in which the continuity was repaired with autologous cartilage in the same position (Nolst Trenité et al., 1987). The crushed cartilage implants were as effective as the noncrushed implants in preventing septal perforations. The implants rotated through 90 degrees, showed less intrinsic growth in dorso-ventral direction.

Animals↗
PubMed1987

Reimplantation of autologous septal cartilage in the growing nasal septum. I. The influence of resection and reimplantation of septal cartilage upon nasal growth: an experimental study in rabbits.

The effects of restoration of the dorso-ventral continuity of the nasal septum on the growth of the nose was investigated in growing rabbits. Submucous resection of the middle third of the septal cartilage resulted in characteristic growth disturbances of nose and maxilla. Reimplantation of the resected strip of autologous cartilage did not restore the normal development of the nose. The implants however did prevent septal perforations as seen after resection of cartilage only and showed a considerable growth in dorso-ventral direction.

Animals↗
PubMed1986

A histologic study of the growth of the subglottis after endolaryngeal trauma.

In young rabbits the histologic features of the growth of the subglottis were studied after an endolaryngeal trauma. This lesion of the larynx leading to a subglottic stenosis, caused specific pathologic changes of the cricoid cartilage and the subepithelial tissues. Activation of chondrocytes resulted in proliferation and regeneration of destructed cartilage. The normal subepithelial structures were replaced by granulation tissue differentiating into a thick fibrous scar and into cartilage. This ectopic cartilage together with the repaired cricoid formed a composite thickened 'ring'-like cartilaginous structure in the adult stage.

Age Factors↗
PubMed1986

A morphometric study of the growth of the subglottis after endolaryngeal trauma.

In young rabbits the growth of the subglottis was studied over a period of 20 weeks following an endolaryngeal trauma. This lesion of the larynx at the age of 4 weeks resulted in the development of a stenosis in the adult stage. The stenosis appeared to be caused by a specific change in the pattern of growth leading up to an anterior narrowing ('pear'-like) of the cricoid ring and a conspicuous thickening of the subepithelial layer.

Age Factors↗
PubMed1980

The influence of partial resections of the nasal septal cartilage on the growth of the upper jaw and the nose: an experimental study in rabbits.

After birth the facial skeleton grows more, and over a longer period, than the neurocranium. The facial skeleton shows an extra growth in comparison with the latter. In young rabbits the dorso-ventral continuity of the septal cartilage was interrupted by various partial resections. It appeared that a discontinuity of the septal cartilage does not prevent all growth of the nose and maxilla but interferes with their extra growth, in particular the lengthening of the nose and the upper jaw and the postnatal ventral displacement of the molar complex and maxilla.

Animals↗
PubMed1979

The effects of septal surgery on the growth of nose and maxilla.

Experiments in growing rabbits showed the great importance of the nasal septum for the postnatal growth of the facial skeleton. The influence of surgical procedures on the morphogenetic function of the nasal septum was investigated. The effects of unilateral and bilateral elevation of the mucoperichondrium and of submucous resection of various parts of the septal cartilage on the growth of the nose and upper jaw are demonstrated.

Adolescent↗