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C D'Angelo

Publications and source records attributed to C D'Angelo.

26 records · Page 2Linked to original sources
PubMedDate not supplied

[Neuropathological study of a case of progressive familial myoclonic epilepsy (author's transl)].

We previously reported (Europ, Neurol., 3, 347-364, 1970) on two clinical observations of progressive myoclonus epilepsy in the same family. Now, we complete the clinical study showing the neuropathological findings concerning one of the two patients who died at the age of twenty. Degenerative neuronal alterations were found involving the olivo-cerebello-rubral system and, in a minor degree, the brain stem and thalamic structures. No Lafora bodies were found. These pathological features make it possible to suggest a differentiation from a first group of progressive myoclonus epilepsy (Unverricht-Lundborg) and another group (with epileptic manifestations) of dyssynergia cerebellaris myoclonica (Ramsay Hunt). We agree with the suggestion of other authors that it is difficult to establish precise differentiations between these groups at neuropathological level. We think however that the distinction is still possible on the basis of the clinical picture. Our observations cupport the hypothesis that our patient is an "abiotrophic" case of Unverricth-Lundborg syndrome, as we previously had suggested on clinical and especially neurophysiological findings.

Adult↗
PubMedDate not supplied

Gastric cancer cell DNA content correlates with early and late results after gastrectomy.

The DNA content of 59 adenocarcinomas of the stomach in patients who had undergone subtotal or total gastrectomy more than 5 years before was measured. The DNA measurements were done by flow cytometry performed on Propidium Iodide--stained cells disaggregated from paraffin-embedded tissues. Fifty-nine evaluable good quality histograms of DNA ploidy patterns were obtained. The Proliferative Index (PI) was determined in 35 cases. The remaining 24 cases didn't show a reliable reading histograms. Of the 59 tumors, 33 (56%) were diploid and 26 (44%) were aneuploid; 19 showed a high PI (> or = 3.8%) and 16 a lower one. A statistically significant difference was found between the two groups (diploid/aneuploid and low/high PI) compared to the prognostic values known as T, N and Stage. 65% of the T3-T4 cancers, 54% of the N1-N2 lesions and 58% of the stage III and IV were found to be aneuploid. 73.7% of the 19 tumors presenting high PI, showed an aneuploid pattern. A high PI was found in 71.4% of the T3-T4 tumors. 77.4% of patients of the diploid group (any stage) survived at 5 years against 36% of those presenting aneuploid patterns. Patients with PI > or = 3.8% showed a 42.1% 5-year survival rate. A 94.4% 5-year survival rate of diploid and early stage cancers was documented against a 33.5% of aneuploid and advanced stage cancers.

Adenocarcinoma↗
PubMedDate not supplied

[The peripheral circulation: ECG-gated magnetic resonance angiography].

This work was aimed at comparing magnetic resonance angiography (MRA) with and without ECG gating in the study of peripheral vessels. Ten volunteers, mean age 27.8 years, were examined with MRA of the femoral, popliteal and tibial segments. MRA was performed with a 1.5-T superconductive magnet, a transmit head coil and the TOF 2D technique. In all cases MRA was performed without cardiac gating and with different times of trigger delay (0, 20, 40, 70 and 200 ms). When comparing the different acquisitions, the number of vessels and the signal-to-noise (S/N) ratio were calculated. In the femoral segment, MRA without cardiac gating showed a mean of 7.7 vessels with 2.79 S/N ratio; MRA with 0 ms of trigger delay showed a mean of 13.1 vessels with 1.51 S/N ratio; MRA with 20 ms trigger delay showed a mean of 13.1 vessels with 1.52 S/N ratio; MRA with 40 ms trigger delay showed a mean of 13.2 vessels with 1.52 S/N ratio; MRA with 70 ms trigger delay showed a mean of 13.5 vessels with 1.50 S/N ratio; finally, MRA with 200 ms trigger delay showed a mean of 13.4 vessels with 1.50 S/N ratio. In the popliteal segment, the corresponding values were 6.4 vessels and 2.51 S/N ratio, 11.4 vessels with 1.54 S/N ratio, 11.3 vessels and 1.54 S/N ratio, 11.6 vessels and 1.52 S/N ratio, 11.8 vessels and 1.52 S/N ratio and, finally, 11.9 vessels and 1.52 S/N ratio. In the tibial segment, the corresponding values were 8.5 vessels and 1.84 S/N ratio, 14.4 vessels and 1.14 S/N ratio, 14.5 vessels and 1.17 S/N ratio, 14.5 vessels and 1.14 S/N ratio, 14.3 vessels and 1.17 S/N ratio and, finally, 14.5 vessels and 1.19 S/N ratio. To conclude, MRA with cardiac gating better visualized peripheral vessels whatever the trigger delay.

Adult↗
PubMedDate not supplied

The role of multiploidy as unfavorable prognostic variable in colorectal cancer.

OBJECTIVE: To analyze the prognostic value of DNA multiploidy in a prospective study on frozen surgical tissue samples from primary colorectal cancer. SUMMARY BACKGROUND DATA: Survival data from eleven prospective studies collectively comprising about thirteen hundred patients showed that aneuploidy correlated with a 5-year disease-free survival (DFS) significantly poorer than diploidy, and showed the limited prognostic value of results from retrospective studies employing paraffin-embedded material. METHODS: Multiple tumor samples of fresh/frozen surgical tissues from 120 colorectal cancer patients who had undergone radical surgery were taken for flow cytometric analysis of DNA content, and proliferative activity, shown as percentage of cells in S-phase (%S). The minimum follow-up of this series was 30 months. Univariate and multivariate analyses determined the independent significance of both clinical and biological variable on DFS. RESULTS: Values of %S equal to or higher than 17.3 correlated with a 5-year DFS poorer than values lower than 17.3 (44.5% vs 85.2% respectively; p = .03), even if only in patients younger than 64. The subgroup with multiploid tumors showed a significantly poorer 5-year DFS (44.5% vs. 62.6% in the non multiploid patients; p = .02). Subgrouping the Dukes'B stage alone by multiploidy, the difference in DFS was much more evident (31.2% vs. 68% respectively; p = .0004) and multivariate analysis showed multiploidy as the only significant variable. Above all, adjuvant therapy did not absolutely modify the unfavorable outcome of the multiploid Dukes'B patients. CONCLUSIONS: The prospective evaluation of ploidy allowed us to identify a very high-risk subgroup of patients with multiploid tumors. This biological characterization was easy to demonstrate and, above all in node-negative patients, reliable and very effective in terms of prognosis. The presence of multiploidy should result in a more aggressive therapeutic approach in the adjuvant setting.

Aneuploidy↗