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Biomedical subjects

C Dadak

Publications and source records attributed to C Dadak.

At least 19 recordsLinked to original sources
PubMed1994

Necrotizing fasciitis arising from episiotomy.

Necrotizing fasciitis is a fatal, rapidly progressive, often initially unrecognized condition. Mortality rates range from 30% to 76%. Prognosis depends on the delay of diagnosis, antimicrobial treatment and surgical excision of all necrotic tissue. A case of postpartum perineal necrotizing fasciitis arising from episiotomy is presented. Prompt recognition and aggressive therapy resulted in a favorable outcome despite significant morbidity.

Adult↗
PubMed1993

[15 years vaginal delivery in post-cesarean status].

In a retrospective study covering a period of 15 years (1976-1991), we investigated 673 births after previous caesarean section compared to a matched pair group. During the observation period, an increase of vaginal delivery after previous caesarean section occurred. This decrease in resection rate (first five years period: 59%, 60% in the period of 1981-1985 and 42% within the last five years) could be achieved mainly in births after only one previous caesarean section. In patients with more than one previous caesarean section, the resection rate remained almost stable at 95%. The rate of complication was low in our study group, especially, if compared to studies in the USA. Three uterine ruptures with one maternal death occurred during the entire observation period. No correlation of the complication rate with an increase of vaginal delivery was observed. The more conservative obstetrical management had no negative impact on foetal outcome.

Apgar Score↗
PubMed1992

The significance of determining CA 15-3 in the cytosol of breast cancer.

The identification of tumor markers in patients who had undergone operation for breast cancer provides important information in the follow-up in addition to evaluation by clinical and visual methods. The aim of our study was to determine the clinical prospective value of CA 15-3, mucin-like carcinoma-associated antigen and carcinoembryonic antigen in preoperative measurement of serum samples in patients with primary breast cancer, and to determine CA 15-3 and steroid receptors in the cytosol of the tumor. The results show that the most exact correlation occurred between serum CA 15-3 and the different stages of the tumor. However, there is no conclusive evidence for the prognosis and the course of the disease from preoperative findings of tumor markers in serum samples or in the cytosol of the tumor in patients with breast cancer.

Adult↗
PubMed1992

[The value of intraoperative rapid biopsy study in diagnosis of breast cancer].

432 biopsies of mammary tumours performed between 1988 and 1990 were reviewed to evaluate the accuracy of rapid frozen section diagnosis. 15 (3.47%) had to be deferred to await subsequent permanent paraffin section. There were 4 (2.55%) false negative diagnoses. These cases consisted of small, nonpalpable and in-situ lesions. No false positive diagnosis was noted during the observation period. Sensitivity of frozen section histology was 97.45%, specificity 100% and efficiency 96.53%. Rapid frozen section diagnosis is a highly accurate and reliable tool which helps to avoid a consecutive operation in patients with breast cancer.

Adult↗
PubMed1992

[Surgical treatment of invasive malignancies of the vulva using CO2 laser].

In a retrospective study, we analysed 26 CO2-laser vulvectomies within the observation period between 1982 and 1990. Indications for vulvectomies were invasive malignancies of the vulva, FIGO stage I to III. 91.7% were squamous cell carcinomas. The mean age of patients was 69.3% (43 to 87) years. Five radical local excisions, one modified radical vulvectomy and in all other cases radical vulvectomy was performed. Laser surgery of the vulva was combined with bilateral lymphadenectomy or radiotherapy of inguinal lymph nodes. If necessary, a gluteal rotation flap was built to achieve closure of the wound without tension. No serious intra- or postoperative complications were observed, wound breakdown with per secundam healing as the most common complication occurred in 29.1%. Functional and cosmetic results were examined in a detailed follow-up at least 12 months postoperatively, showing promising results (56.3% good, 37.5% satisfactory, 6.3% unsatisfactory). The surgical procedure, perioperative management, recurrence rate (3 patients, 12.5%), as well as functional and cosmetic results, are presented and discussed in detail. The use of CO2-laser in surgical treatment of vulvar malignancies improves cosmetic and functional results. This is important, particularly with regard to the increasing number of young women with vulvar neoplasia.

Adult↗
PubMed1990

Effect of carnitine on foetal rat lung dipalmitoyl phosphatidylcholine content and lung morphology. Carnitine and lung surfactant, I.

Lungs of foetal rats between the 16th and 20th gestational day (total gestation lasting 22 days) were examined. There was a striking increase of both total phosphatidylcholine and dipalmitoyl phosphatidylcholine from day 19 to 20 of gestation. The carnitine content increased continuously from day 17 both in the foetal lungs and livers. In both organs, the increase in short-chain acylcarnitine was more pronounced than the increase in free carnitine. Compared with an untreated control group, treatment of the mother with L-carnitine (from day 16 to 18 of gestation, with 60, 80, and 100 mg/kg.d L-carnitine, respectively) resulted in significant increases in both total phospholipid (p less than 0.05 in all treated groups) and dipalmitoyl phosphatidylcholine (p less than 0.05, p less than 0.01, p less than 0.001, corresponding to maternal treatment with 60, 80, 100 mg/kg.d, respectively) on the 19th gestational day. The results are in accordance with morphological evaluations: with increasing carnitine-dosage, increasing numbers of lamellar bodies in type II cell progenitors were found. The enhanced dipalmitoyl phosphatidylcholine content is a consequence of enhanced phospholipid synthesis in remarkably undifferentiated type II cells largely lacking membrane structures and cell organelles capable of phospholipid synthesis. Thus, in general, carnitine treatment seems to stimulate foetal lung phospholipid synthesis, thereby enhancing the dipalmitoyl phosphatidylcholine content.

1,2-Dipalmitoylphosphatidylcholine↗
PubMed1989

[Exposure to radioactivity in the perinatal period following the reactor accident in Chernobyl].

After the Chernobyl nuclear accident on 26 April 1986 Europe experienced increased radioactive radiation by contamination of the atmospheric aerosol and the soil. Foods emanating radioactive radiation were ingested by the population to an increased extent via the food chain. This proportion of radioactive radiation accounted for about 80% of the total irradiation exposure and prompted us to examine mother's milk, amniotic fluid and placenta of newborn in respect of their concentrations of radionuclides I-131, Cs-134 and Cs-137. Due to the short half-life of I-131 an increased concentration of this substance was seen only during the first eight weeks after the nuclear accident. On the other hand, however, there was a clear increase in Cs-134 and Cs-137 from this time onward, the highest concentration of these two nuclides being measured only after one year after the accident. Despite the enhanced exposure to radioactivity of mother's milk and amniotic fluid, the guideline values laid down by Federal German legislation were not exceeded.

Accidents↗
PubMed1988

[Organ-sparing surgery of leiomyomas of the uterus in young females].

At the IInd Dept. of Obstet. and Gynaecology, University of Vienna, in the five year period between 1979 and 1984 enucleation of uterine leiomyomas was performed in 27 cases. At the time of operation all of them desired children. All leiomyomas were located in the uterine corpus. The biggest one held 13 cm in diameter. In spite of avoiding endometrial lesions the cavity of the uterus was opened during surgery in 5 cases. None of the patients showed intra- or postoperative complications. We were able to receive follow-up informations of 21 patients. In 8 cases different contraceptives were used. 8 women became pregnant after surgery. Five of them had term deliveries, in three cases early abortions occurred. One woman suffered from recurrent leiomyomas, which led to hysterectomy 3 years later. These findings suggest that conservative surgery in cases of leiomyomas of the uterus could promote or preserve young women's fertility.

Adult↗
PubMed1987

[Type I diabetes mellitus and pregnancy: an interdisciplinary management program].

The obstetrical management of pregnant women with pregestational diabetes has been significantly improved throughout recent years. In the past, efforts to maintain euglycaemia during pregnancy in the presence of a labile maternal metabolism led to repeated, long-term hospitalization. In an interdisciplinary joint effort a protocol was delineated to obtain euglycemia throughout pregnancy by functional insulin therapy aiming at "near-normoglycemic insulin substitution (NIS)". In order to achieve this goal, home glucose monitoring and, depending on the glucose levels, self-made adjustments to the insulin therapy (according to individual algorithm) are the essential parts of this protocol. Of our study group of 18 pregnant diabetic women, already eight of them (2 class B, 1 class C, 1 class D, 2 class R and 2 class RF) have been delivered. The mean maternal age was 27 years (21-39). All metabolic variables of consequence for a diabetic woman were within the normal limits. The mothers' mean weight gain was 16 kg (12-20), and the mean gestational age at delivery was 37.8 weeks (35-40). The mean birth weight was 3293 grams (2700-3700) and all newborns were within the 50th percentile. Five fetuses were delivered by caesarian section (indications: proliferative retinopathy 3, breech presentation 1, previous caesarian section 1). No congenital malformations were found, nor macrosomia, respiratory distress syndrome or postpartum hyperglycaemia in the newborn. These preliminary results are encouraging. We feel that functional insulin therapy aiming at "near-normoglycaemic insulin substitution" promises to be very effective for women who are able and willing to follow the instructions received in the special education program.

Adult↗