Biomedical subjects

C Danielescu

Publications and source records attributed to C Danielescu.

5 recordsLinked to original sources

PubMed2006

[Efficiency of air tamponade in prevention of early recurrence of vitreal hemorrhage in diabetic patients with vitrectomy].

PURPOSE: To evaluate the efficacy and safety of air endo-tamponade in preventing early recurrence of vitreous hemorrhage in diabetic vitrectomy. MATERIALS AND METHODS: Prospective, consecutive, interventional, non-randomized study including 40 eyes (from 40 patients) with persistent or recurrent vitreous hemorrhage related to proliferative diabetic retinopathy. At the end of vitrectomy 20 cases (study group) were assigned to complete fluid--air exchange while the other 20 cases (control group) were left with BSS Plus. RESULTS: Early postoperative bleeding occurred in 9 out of 40 cases--22.5% (3 cases from the study group--15% and 6 cases from the control group--30%, p < 0.05). There was no statistically significant difference in visual acuity, intraocular pressure or incidence of late-onset hemorrhage recurrence between both groups during 6-month postoperative follow-up. In the study group there was a higher rate of lens opacities appearance. CONCLUSIONS: Air endo-tamponade seems a simple and efficient way of preventing early recurrence of vitreous hemorrhage in diabetic vitrectomy. Higher rate of lens opacities appearance may counteract this advantage thus this technique could be safely and electively used in pseudophakic patients.

Adult↗

PubMed2006

[A comparative analysis of standard automated perimetry and short wavelength automated perimetry in early diagnosis of glaucoma].

PURPOSE: To assess the concordance between standard automated perimetry (SAP) and short wavelength automated perimetry (SWAP). To analyze comparatively the early detection and the extent of visual field defects in glaucoma suspects and in early glaucoma. METHOD: A prospective, randomized study that included 55 patients (107 eyes), glaucoma suspects or with early glaucoma who were randomly subject to both SAP and SWAP; the examinations were repeated at 3 and 6 months in order to establish that the visual field defects were real. The studied parameters were the mean value of MD and PSD in the two techniques, the correlation between the results (global and on patients subgroups), the percentage of patients in which the defects were larger, deeper or new defects were found when examined in SWAP. RESULTS: There was no statistically significant difference in the MD value between the two methods (-3.42 +/- 5.17 dB in SWAP, -2.83 +/- 4.84 dB in SAP, p = 0.14); the PSD value was significantly higher (p < 0.0001) in SWAP (3.63 +/- 1.36 dB) than in SAP (2.66 +/- 1.97 dB). There was a high correlation of the MD and PSD values between the two techniques; the highest correlation appeared in POAG patients. The SWAP test has evidenced visual field defects in 10.1% of eyes with normal SAP tests and also larger and deeper defects in 18.7% of cases. CONCLUSIONS: The SWAP and SAP results were concordant; the visual field defects were earlier detected, appeared larger and deeper in SWAP than in SAP.

Adolescent↗

PubMed2005

[Learning effect in computerized perimetry].

PURPOSE: To highlight the learning effect in automated perimetry and to assess the value of the first visual field in glaucoma diagnosis. METHOD: A prospective study that included 48 patients (91 eyes)--glaucoma suspects--who performed 3 visual field tests in no more than 12 months. RESULTS: 32 eyes were diagnosed with intraocular hypertension and the others with POAG. An improvement (expression of the learning effect) was noted in 45.05% of eyes (in an average of 3.39 2,72 points) in the second visual field and in 37.36% of eyes (3.05 2.13 points) in the third visual field. Considering (as a hypothesis) the third visual field as gold standard, the first test had a sensitivity of 87.03% and a specificity of 89.18% in detecting visual field defects (efficiency 89,01%). The second test had a sensitivity of 92.59% and a specificity of 89.18% (efficiency 91.2%). CONCLUSIONS: The learning effect was present in the first three tests, but seems to have little influence on the diagnosis of visual field defects. A possible explanation is the presence to a large extent of important visual field loss (obvious from the first test) in the included patients.

Adolescent↗

PubMed2005

Comparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, randomized, masked, cross-over design study.

PURPOSE: To analyse comparatively the efficacy and tolerance of latanoprost, travoprost and the fixed combination timolol-dorzolamide in the treatment of primary open angle glaucoma and ocular hypertension. METHOD: Prospective, investigator masked, randomized study that included 38 patients (38 eyes) with primary open angle glaucoma uncontrolled under beta blockers. Each patient received latanoprost, travoprost and the fixed combination timolol-dorzolamide (for 3 months each). The first drug and the order of the next drugs administered were randomized. The follow up period was 9 months. At the baseline and at the end of each therapeutic period (3 months) we determined the IOP (at 8, 10 a.m. and 4 p.m.), visual acuity, C/D ratio, blood pressure, heart rate and local tolerance. We have also photographed the eyelids, lashes, conjunctiva and iris. After each month of treatment we determined the IOP (at 8 and 10 am), visual acuity, blood pressure, heart rate and local tolerance. RESULTS: The mean initial IOP was 25.1 2.89 mmHg and after 9 months of treatment 21.67 4.59 mmHg. Each drug induced a statistically significant IOP decrease (the fixed combination timolol-dorzolamide decreased IOP with 14.33%, travoprost with 18.39% and latanoprost with 22.1%). The IOP lowering was comparable for the prostaglandin derivatives and superior to the fixed combination timolol-dorzolamide. None of these drugs had a negative influence on the visual field, C/D ratio, visual acuity, blood pressure and heart rate. There was good local tolerance. The side effects were more frequent after travoprost (37) and latanoprost (22) than after the fixed combination timolol-dorzolamide (4 cases). The most important adverse events for the prostaglandin derivatives were conjunctival hyperemia, eyelashes pigmentation and growth, iris pigmentation. There was no necessary to stop the medication because of these effects. CONCLUSIONS: Travoprost, latanoprost and the fixed combination timolol-dorzolamide are efficient in the treatment of primary open angle glaucoma. The prostaglandin derivatives determined similar IOP decrease, which was superior to the fixed combination timolol-dorzolamide; the local tolerance was good, the fixed combination causing the fewest side effects.

Aged↗

PubMed2004

[Ring iris melanoma].

We are presenting a case of diffuse (ring) iris melanoma with secondary glaucoma, together with the differential diagnosis issues. The tumor extension and the high IOP imposed the enucleation of an eye that still had a good visual acuity. The pathology confirmed the diagnosis and showed the extension to the anterior chamber angle and the ciliary processes. The prognosis in this rare type of uveal melanoma is worse than in other iris melanomas.

Aged↗