PubMed Health⌕ Search

Biomedical subjects

C Darley

Publications and source records attributed to C Darley.

12 recordsLinked to original sources
PubMed1998

The prevalence of skin disease in HIV infection.

The frequency of skin problems in patients with HIV infection and AIDS is well known from clinical experience and from the reports of cohorts of patients followed over months and years. Decreased mucocutaneous immunity often accounts for the earliest clinical signs seen in HIV-infected patients. As HIV disease progresses, these skin manifestations may become more severe and varied. In advanced immunosuppression, opportunistic pathogens may present as atypical cutaneous lesions. The following two cases illustrate a number of important points in relation to the management of skin disease in HIV patients.

AIDS-Related Opportunistic Infections↗
PubMed1992

Cutaneous malignant melanoma and human immunodeficiency virus (HIV) infection: a report of three cases.

Cutaneous malignant melanoma was diagnosed in three patients suffering from human immunodeficiency virus (HIV) infection. Staging at presentation inversely correlated with absolute CD4 count. In addition, a notably sparse lymphocytic inflammatory response to the melanoma was observed in two cases. Established data on melanoma in non-HIV immunosuppressed patients suggests a poor prognosis for melanoma in HIV disease.

Adult↗
PubMed1992

Unilateral linear capillaritis.

We present four cases of a distinctive type of pigmented purpuric eruption occurring in a striking linear and pseudo-dermatomal distribution in young males. Whilst these cases share some of the clinical and histological features of other pigmented purpuric dermatoses, they are not readily classified with any of the entities so far defined in this group of disorders. We believe these cases represent a distinct group not previously described. Four patients with an unusual pigmented purpuric eruption are presented.

Adolescent↗
PubMed1992

Congenital inclusion dermoid cysts of the scalp.

The natural history of congenital inclusion dermoid cysts of the scalp is unknown. We report three cases of this condition, which has been followed from birth for up to ten years. Dermoids are congenital subcutaneous cysts, which gradually flatten and scar over a number of years. The lesions are covered with skin showing focal alopecia but they may be surrounded by a collar of hypertropic hair. Later in life flattened cysts may be mistaken for aplasia cutis, but the history of a cyst at birth allows the clinician to distinguish these two conditions. As these cysts have a potential for intracranial extension, this is an important clinical entity.

Alopecia↗
PubMed1988

Vasculitis complicating treatment with intravenous anisoylated plasminogen streptokinase activator complex in acute myocardial infarction.

Vasculitis developed in six of 253 patients treated with intravenous anisoylated plasminogen streptokinase activator complex (APSAC) after acute myocardial infarction. All patients recovered spontaneously with no evidence of renal impairment and no long term sequelae. Although leucocytoclastic vasculitis and serum sickness have been reported after streptokinase treatment, such allergic reactions have not been described as a complication of other thrombolytic agents.

Aged↗
PubMed1982

The dilution of proprietary corticosteroid ointments--an attempt to evaluate relative clinical potencies.

Ten subjects were assessed using the vasoconstrictor assay technique in a double-blind study in order to evaluate the potencies of several diluted and undiluted proprietary corticosteroid ointments. Results showed that clobetasol propionate 0.05% (Dermovate) ointment at a dilution of one part in ten (clobetasol propionate 0.005%) in white soft paraffin was equipotent with betamethasone valerate 0.1% (Betnovate) ointment; and no difference in potency was demonstrated between beclomethasone dipropionate 0.025% (Propaderm), betamethasone valerate 0.1% (Betnovate) and clobetasone butyrate 0.05% (Eumovate).

Administration, Topical↗