Biomedical subjects
Publications and source records attributed to C Davila.
Oxidative mechanism may play an important role in maturity onset cataract. But, nowadays, there is no answer whether cataract is the result of oxidation per se or of exaggerated and inappropriate physiological responses to oxidation. Also, senile cataract may be considered a conformational disease. Understanding the mechanisms of cataractogenesis will lead to a better therapy.
The objective of this study was to develop an apparatus allowing the generation of a high temperature (exceeding 80 degrees C) in a precise focus (20 mm x 2 mm) by means of extracorporeal elastic waves. The treatment time at high temperatures is brief and administered in sequences of 4 to 7 seconds. In vitro studies on blocks of polyurethane demonstrated melting of the plastic at the focal point. Studies on plastic spheres introduced into the bladder of the pig demonstrated melting of the sphere without any alteration in the tissues in the wave path. Studies of cellular viability of bladder carcinoma cultures demonstrated a significant difference after 48 hours between the non-treated control group and the group of cells submitted to high temperatures. This technique, called Pyrotherapy, should be promising if the preliminary results are confirmed.
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Explore the source record for details and available documents.