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Biomedical subjects

C De Angelis

Publications and source records attributed to C De Angelis.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Continuous peridural analgesia-anesthesia during labor. Experiences and considerations].

Fifty pregnant women attending the Obstetrics Department of the University of Aquila were included in the study. Patients were matched for age, weight, height, parity, Bishop index, temperature, arterial pressure, and cardiotopography. Twenty-five patients were assigned to the control group, the remaining twenty-five received peridural analgo-anesthesia during labour and birth so as to create a continuous lumbar epidural block. The results confirmed that this method of anesthesia is an aid against psycho-physical stress and pain in pregnant women.

Adult↗
PubMed1989

[Atrial natriuretic factor: an epidemiological study. Preliminary results].

We performed an epidemiological study on the atrial natriuretic factor pattern in a young population. Subjects were recruited in the Ospedale Militare Principale of Rome among young men liable to conscription, whose hospitalization was due either to essential hypertension or to other pathologies (not influencing our study, such as headache etc.). The recruitment lead to the formation of three different groups: normotensives, normotensives with family history of hypertension (mother and/or father) and hypertensives. On the morning of the study (after 7 days of pharmacological wash-out, under a diet containing 120 mEq of Na+/die), blood samples were taken. Plasma atrial natriuretic factor, renin activity and aldosterone were assayed by RIA. Digoxin-like immunoreactive substance was assayed by a solid-phase radioimmunoassay, following the extraction of plasma. Serum creatinine, sodium, potassium and urinary sodium and potassium (24 h before the study) were assayed by standard methods. Urinary kallikrein was assayed by chromogenic substrate S-2266. So far, we have studied 60 subjects (26 hypertensives, 21 normotensives and 13 normotensives with family history) and we wish to discuss in this article the preliminary results concerning the atrial natriuretic factor and its relationship with renin activity, aldosterone and blood pressure. Our results show that the mean plasma levels of atrial natriuretic factor in the hypertensive group were higher, although not significantly, than those of the other two groups and that the normotensives with family history had slightly higher levels as compared to normotensives (Delta % = + 7.4).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Acetaminophen: more harm than good for chickenpox?

STUDY OBJECTIVE: To determine whether acetaminophen affects the duration or severity of childhood varicella. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Office- and hospital-based pediatric practices. PATIENTS: Seventy-two children between 1 and 12 years of age entered the study. One child was withdrawn because of high fever, and three children did not complete the study; 31 received placebo and 37 received acetaminophen. INTERVENTIONS: Acetaminophen, 10 mg/kg/dose, was given at 8 AM, 12 PM, 4 PM, and 8 PM for 4 days. Placebo was given to the control group. Itching, appetite, activity, and overall condition were measured for 6 days. The time to last vesicle formation, time to total scabbing, and time to total healing were measured until complete resolution of the exanthem. MEASUREMENTS AND MAIN RESULTS: The following results were better in the placebo group (p less than .05): time to total scabbing 5.6 days (SD 2.5) versus 6.7 days (SD 2.3) in the acetaminophen group, and itching on day 4 in the placebo group (symptom score 2.9 (SD 0.20) vs 2.2 (SD 0.26]. Activity was better in the acetaminophen group on day 2 (3.13 (SD 0.23) vs 2.82 (SD 0.24]. CONCLUSIONS: These results provide evidence that acetaminophen does not alleviate symptoms in children with varicella and may prolong illness.

Acetaminophen↗
PubMed1989

The climacteric and gynaecological cancers.

Epidemiologic data show how the climacteric is definitely an high risk period for the developing of genital and mammary neoplasias. This can be probably explained for the genital district by the hyperestrogenic situation that the climacteric woman experiences and by the promoting effect that estrogens have on the neoplastic growth. As far as the mammary cancer concerns the reproductive history would seem to be more important than the perimenopausal hormonal in determining the high risk woman. Estrogen replacement therapy would seem to be dangerous only for the endometrium while little or no effect can be demonstrated for the ovary and the breast. The combined estrogen-progesterone therapy all the beneficial effects and seems to be absolutely safe.

Climacteric↗
PubMed1988

Effect of angiotensin converting enzyme inhibition on platelet angiotensin II content.

The effect of captopril treatment on platelet angiotensin II levels was evaluated in 12 patients with essential hypertension. Captopril significantly lowered (p less than 0.01) mean arterial blood pressure in seven patients (Group 1) and was ineffective in five (Group 2). In Group 1, a marked decrease in plasma angiotensin II levels in both the supine (from 5.5 +/- 0.5 to 2.8 +/- 0.9 pg/ml) and the upright positions (from 17.5 +/- 4.7 to 3.9 +/- 1.6 pg/ml; p less than 0.0025) and a significant increase in platelet angiotensin II levels (from 10.5 +/- 5.3 to 22.4 +/- 17 pg/ml; p less than 0.05) after captopril treatment was observed. In Group 2, no variation was found in plasma angiotensin II levels, whereas platelet angiotensin II levels increased slightly (from 10.8 +/- 3.1 pg/ml to 16.9 +/- 5.2 pg/ml; NS). These findings suggest that the decrease in plasma angiotensin II levels can lead to an increase in platelet angiotensin II receptors or can lead to angiotensin II production in platelets through activation of a feedback mechanism. The second hypothesis suggests that platelets have alternative enzymatic pathways leading to angiotensin II production not inhibited by captopril.

Adult↗
PubMed1988

Gallbladder kinetics in obese patients. Effect of a regular meal and low-calorie meal.

Gallbladder contractility has been studied in 21 obese patients (greater than 130% ideal weight) and 30 nonobese subjects before and at regular intervals after the administration of a regular solid-liquid meal, and after a low-calorie, low-fat meal used conventionally for weight-loss purposes (Modifast). Gallbladder volume was determined by means of real-time ultrasonography, using a linear array scanner with a 3.5 MHZ probe. In seven of the obese patients, gallbladder contractility was also evaluated after a 10-day regimen with Modifast. The obese group showed a statistically significant greater gallbladder fasting volume and blunted contractility than controls both after the ordinary and the low-calorie meal. The 10-day low-calorie regimen was associated with a statistically significant increment in fasting gallbladder volume, while the percent volume reduction after Modifast did not change. It is suggested that, in addition to metabolic factors, gallbladder hypocontractility in the obese may contribute to the high incidence of cholesterol gallstones noted in these patients. A low-calorie, low-fat diet augmenting gallbladder volume may favor bile stasis and therefore the likelihood of developing gallstones.

Adult↗
PubMed1988

Effect of ketanserin, a selective antiserotoninergic drug, on human anal canal pressure.

The effect of Ketanserin, a new antiserotoninergic drug, on human anal pressure in vivo was investigated. Anal pressure was recorded continuously in 14 normal subjects by a low-compliance water perfused probe with two recording points at the sphincter level. After a 30-min basal tracing Ketanserin (10 mg IV as bolus) or placebo was administered in a double blind manner, and the recording continued for 1 h. The results show that Ketanserin induced a 30% fall in anal pressure soon after its administration which was statistically significant when compared with the placebo (p less than 0.01). This effect lasted up to 40 min of recording and was followed by a return to control values within 1 h.

Adult↗
PubMed1988

Gallbladder contraction and its relationship to interdigestive duodenal motor activity in normal human subjects.

Gallbladder volume and interdigestive gastric and duodenal motor activity were evaluated simultaneously in 12 normal subjects. After overnight fasting, gallbladder volume was monitored every 4 min in each subject by means of real-time ultrasonography, and gastroduodenal motor activity was measured by means of a probe consisting of three polyvinyl catheters with one side opening for each catheter, placed 15 cm apart and constantly perfused with deionized water. Real-time ultrasonography and intestinal manometry were performed by different investigators and continued until at least two consecutive spontaneous phase III activities of migrating motor complexes were observed. The results show a cyclic variation of gallbladder volume, which reached its minimum value before the end of phase II in the proximal duodenum and its maximum in early phase II, 25 min after the beginning of phase III. These results suggest that there is a relationship between the cyclic gallbladder volume changes, which occur during fasting in humans, and with the various phases of duodenal migrating motor complex.

Digestion↗
PubMed1988

Pancreatic steatorrhea and pulmonary tuberculosis.

The authors present a case of exocrine pancreatic insufficiency in a 37 yr old woman treated for pulmonary tuberculosis. The exocrine pancreatic failure is suggested to be secondary to previous pancreatic tuberculosis since no other cause of pancreatic disease was found and the diarrhea with steatorrhea started 6 mth after the lung disease. Steatorrhea was promptly reverted after institution of oral therapy with pancreatic supplements and the patient gained 7 kg of body weight during the successive follow-up of 4 yr.

Adult↗
PubMed1988

Effect of nicardipine on angiotensin II platelet content.

We evaluated the effect of nicardipine treatment on platelet angiotensin II content in 18 essential hypertensive patients. Nicardipine induced a decrease in platelet angiotensin II content in all patients (-14%), but particularly in 10 (P less than 0.05; -20.5%). No other differences were found between these patients and the others. Further investigations are required to determine whether platelet angiotensin II content reduction contributes to the prophylactic and therapeutic effects of calcium antagonists on atherosclerosis.

Aged↗
PubMed1988

Blood platelets and angiotensin II: angiotensin II release after platelet aggregation.

Recent studies have demonstrated the presence of angiotensin II (Ang II) in human platelets. The aim of the present study was to determine whether in vitro platelet aggregation induces Ang II release. We studied 20 healthy volunteers, and found that some aggregant stimuli can cause the platelet to release this peptide. Release of Ang II was greater with thrombin (40.7%) than with ADP (29%), while N-ethylmaleimide was almost ineffective. The release of Ang II following in vitro aggregant stimuli suggests that this may be one of the mechanisms through which platelets can locally modulate vascular tone and perhaps promote atherogenesis.

Adenosine Diphosphate↗
PubMed1986

Chromosomal localization of the human oncogene ERBA2.

The human ERBA2 gene has been mapped to chromosome 17q21.3 by in situ hybridization. A second hybridization site at 17q25 was greatly reduced by high stringency washes, indicating the presence of an additional member of the ERBA2 family at this location. Southern blot hybridization using identical conditions did not reveal additional bands, and hybridizations done at sufficiently low stringency to reveal further bands produced multiple bands rather than the single additional band expected from the in situ results. Direct comparisons of in situ and Southern hybridizations should therefore be treated with caution. The location of these two oncogenes may be significant in cases of acute promyelocytic leukaemia and acute nonlymphocytic leukaemia.

Chromosome Banding↗