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Biomedical subjects

C De La Porte

Publications and source records attributed to C De La Porte.

12 recordsLinked to original sources
PubMed1995

Changes in metabolism of cerebral glucose after stereotactic leukotomy for refractory obsessive-compulsive disorder: a case report.

Brain glucose metabolism was investigated with PET and [18F]fluorodeoxyglucose, before and after a bifrontal stereotactic leukotomy in a 37 year old woman with refractory obsessive-compulsive disorder. A bilateral decrease in glucose metabolism was found in the orbital frontal cortex after psychosurgery. Glucose metabolism was decreased to a lesser degree in Brodmann's area 25, in the thalamus, and in the caudate nucleus. Clinical improvement in obsessive-compulsive disorder after stereotactic tractotomy seems to be associated with metabolic changes in the brain, in particular, in the orbital part of the frontal lobe.

Adult↗
PubMed1994

Long-term pain relief during spinal cord stimulation. The effect of patient selection.

We reviewed our experience with spinal cord stimulation (SCS) in treating 116 patients with pain in one or both legs. All these patients were selected for an initial week of trial stimulation by the criteria: pain due to a known benign organic cause, failure of conventional pain control methods and absence of major personality disorders. Selected patients included 78 with the Failed Back Surgery Syndrome (FBSS), in whom proven correlation existed between the clinical picture and the neuroradiological and electromyogram abnormalities. Eighty-four out of 116 selected patients underwent definitive SCS implantation after 1 week of trial stimulation with excellent results (more than 75% pain relief). They were followed clinically every 3 months for a mean follow-up period of 47 months. Forty-five patients (54%) continued to experience at least 50% of pain relief at the latest follow up. Seventy-seven patients (91%) were able to reduce their medication intake and 50 patients (60%) reported an improvement in lifestyle. FBSS patients responded more positively to the trial stimulation than the other patients. However, the later outcome was not affected by patient selection as long-term benefit was similar in all definitive SCS patients irrespective of aetiology.

Adult↗
PubMed1990

Consequences and complications of glycerol injection in the cavum of Meckel: a series of 120 consecutive injections.

From 1983 to 1989, 120 injections of glycerol into the trigeminal ganglion were performed to treat facialgias of different origin. The subjective and objective consequences and complications are reviewed. Since this operation yielded most often mild, transient and well tolerated consequences and complications for the patient, we now propose this method as first choice for trigeminal neuralgia when there is no anamnestic or clinical evidence of damage to the trigeminal system.

Adolescent↗
PubMed1983

[Parameters of high-frequency thermocoagulation of the Gasserian ganglion in the treatment of trigeminal neuralgia in order to obtain analgesia without anesthesia].

Voltage and current within Gasserian ganglion have been measured during a therapeutical high frequency coagulation of the Gasserian ganglion in 25 consecutive cases. From these values, the impedance (Ohm), the work (Watt) and the total energy (Joule) necessary to obtain an analgesia without anesthesia have been calculated. The study has shown that the temperature and the time of coagulation in correlation with the length of the non isolated tip of the electrode are actually the only constancy in the control of the therapeutical lesions.

Electrocoagulation↗
PubMedDate not supplied

Gadolinium-DOTA enhanced MR imaging of intracranial lesions.

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (Gd-DOTA) is the first of a new class of macrocyclic paramagnetic magnetic resonance (MR) contrast agents (gadolinium cryptelates) to be used in clinical practice. Gadolinium-DOTA possesses relaxation properties similar to those of gadolinium diethylene triamine pentaacetic acid (Gd-DTPA). We report our initial clinical experience in 38 patients with intracranial lesions studied with MR before and after injection of Gd-DOTA. Diseases included primary and metastatic brain tumor, cerebral infarct, vascular malformation, meningioma, hemangiopericytoma, schwannoma, and pituitary macroadenoma. Gadolinium-DOTA was administered intravenously in a dosage of 0.1 mmol/kg body weight. All studies were performed on a superconductive 0.5 T system. As compared to noncontrast T1- and T2-weighted images (WI), Gd-DOTA enhanced T1 WI were useful in defining the anatomy of malignant intraaxial tumors (high-grade glioma, metastasis) and in tumor versus edema differentiation. Low-grade gliomas did not enhance; in these cases the precontrast T2-weighted sequence was found to be more informative. In post-operative patients, Gd-DOTA allowed us to demonstrate residual tumor or tumor recurrence. Extraaxial tumors (meningioma, hemangiopericytoma, neuroma) enhanced markedly, presumably reflecting tumor vascularity. In our experience, the use of Gd-DOTA improves the anatomic definition of cerebral lesions and in some cases increases both MR sensitivity and specificity. We found Gd-DOTA to be a well tolerated and effective paramagnetic contrast agent. Gadolinium-DOTA can be considered as an alternative water-soluble MR contrast agent to Gd-DTPA.

Adult↗
PubMedDate not supplied

Transcranial Doppler sonography.

A general review of the physical principles and the applications of transcranial Doppler (TCD) sonography is given. This new non-invasive technique is presented as an important diagnostic tool in neurology, neurosurgery and intensive care medicine. The applications are documented using our own patient material.

Cerebrovascular Circulation↗