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Biomedical subjects

C De Sousa

Publications and source records attributed to C De Sousa.

4 recordsLinked to original sources

Contaminated sites: the Canadian situation in an international context.

Over the last 2 decades, policy-makers have been giving increasing attention to the remediation and redevelopment of contaminated sites, especially those located in urban areas commonly referred to as brownfields. Traditionally, private developers have tended to ignore these sites on account of a series of obstacles of a structural-political nature, including variability in regulatory processes, lack of information on soil quality, impractical clean up standards, fear of liability, and limited funding resources for clean ups. This paper examines the types of policy-making measures that are currently being taken in Canada to overcome these obstacles, comparing them to those being taken in the US and Europe. It is argued that the contaminated site-related policies and programs employed to overcome each obstacle, both within Canada and internationally, are converging in style and content as governments are becoming more aware of the types of costs and risks they must share in order to solve the problem effectively. It is also argued that this trend is unfolding in a relatively predictable way, and that policy-making in Canada is evolving more slowly than it is in the other jurisdictions examined.

Canada↗

Cerebellitis presenting as acute hydrocephalus.

A 14-year-old boy presented acutely with occipital headache, nausea and vomiting. MRI showed obstructive hydrocephalus and marked bilateral cerebellar swelling with increased signal on T2-weighted imaging. Following treatment with oral corticosteroids, the clinical and radiological signs resolved. The clinical course and radiological appearances were consistent with cerebellitis associated with a significant mass effect and hydrocephalus.

Adolescent↗

Carnitine and weakness in haemodialysis patients.

Weakness in haemodialysis patients has been attributed to several factors including carnitine deficiency. Malnutrition, neuropathy, uraemic myopathy and parathyroid hormone excess may all be important. Six haemodialysis patients were shown to have reduced muscle power compared with a normal population, and to be malnourished by dietary assessment, and features of their weakness were investigated. Total carnitine was normal in plasma but elevated in muscle, with an excess of esterified carnitine in both plasma and muscle and diminished free plasma carnitine. Muscle biopsy showed no features of carnitine deficiency and electromyography showed a non-specific neuropathy with additional myopathic changes in some. Dietary supplementation with L-carnitine (2 g/day) for 6 weeks in a placebo-controlled trial showed a redistribution of carnitine fractions but no subjective or objective improvement in muscle function. There was no improvement in the plasma lipid profile. The weakness of haemodialysis patients is multifactorial. We have not demonstrated total carnitine depletion in either muscle or plasma, and oral supplementation of L-carnitine has no demonstrable effect in this group.

Administration, Oral↗