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Biomedical subjects

C De With

Publications and source records attributed to C De With.

10 recordsLinked to original sources

Birthweight distribution in a healthy urban population in Surabaya-Indonesia.

The birthweight distribution was assessed in an apparently healthy urban population in Surabaya, Indonesia. A total of 924 pregnant women of a middle income group were enrolled at 20-24 weeks of gestation of which 543 women delivered in the university hospital. In the latter group mean birthweight of liveborn singletons was 3047 g for males and 2900 g for females. The percentages of low birthweight by sex were 7.9% and 13.8% respectively. These values were lower than those reported for more affluent women in Indonesia and comparable with those of rural Madurese women studied in the same time period.

Adolescent↗

Energy supplementation in the last trimester of pregnancy in East Java: I. Effect on birthweight.

The effect of two levels of energy supplementation in the last trimester of pregnancy on birthweight was tested in a controlled randomized trial in three villages in Madura, East Java. The high and low energy supplements provided 1.95 MJ (465 kcal) and 218 kJ (52 kcal) per day respectively. In the baseline period the home diet provided on average 6.28 MJ (1500 kcal) (SD 2.1 MJ (499 kcal] and 41 g (SD 13 g) of protein. The mean birthweight was 2835 g and the rate of low birthweight 12.2%. In the experimental period the home diet was better. The average intake ranged from 6.45 to 7.19 MJ (1541-1717 kcal) and 41.4-44.2 g per day, depending on the degree of compliance. Mean birthweight increased by 100 g and the rate of low birthweight dropped to 9.5%. There was no difference between the high and low energy supplemented group as a whole, probably due to the masking effect of the better home diet in the experimental period. It is likely that a positive effect of energy supplementation on birthweight was restricted to the group of pregnant women with the lowest home dietary intake and/or a low prepregnant weight. In this community targeting of supplementation to lean seasons and/or to women with a low prepregnant weight may be cost-effective.

Birth Weight↗

Birthweight distribution in the Mantsonyane area: Lesotho.

A total of 832 maternal and newborn records in a rural hospital in Lesotho were analysed. The mean birthweight was 3.07 kg and the incidence of low birthweight rate 7.5%. This was compared with other countries in Africa. Increasing birth order was associated with higher birthweight irrespective of maternal age, except for the very young mothers. No seasonal variation in birthweight was observed. Of 313 newborns the gestational age was assessed. The overall anthropometric measurements of newborns in the Mantsonyane area were comparable to better off industrialized countries.

Adolescent↗

Two-stage plans for the testing of binomial parameters.

Two-stage plans, a middle course between fixed-sample-size plans and sequential plans, are a worthwhile tool. Attention is given to the testing of binomial parameters in two-stage plans. Tables are given for testing pi = 0.5 in one population, the sign-test situation. An example demonstrates how these tables can be used for testing the equality of the binomial parameters in two populations as well. Results of the two-stage plans are compared with fixed-sample-size plans, sequential plans, and other published results.

Clinical Trials as Topic↗

Nutrition and nutritional status of rural women in East Java.

In the rural parts of nine regencies of the province of East Java Indonesia, in the dry seasons of 1975 and 1976 extensive nutrition surveys were carried out. So designated surplus, marginal and minus areas were included. Social and hygienic features of the household were recorded. The reproductive characteristics of the mother population were noted. Anthropometric data were collected. Their diet, including consumption frequency of staple and secondary foodstuffs, was registered by interview. Of a total of 3,828 mothers of children 0--15 years old 37% were lactating and 6.7% were pregnant. Of the latter some 10% were still nursing a child. The number of live children per family was rather small (2.0--3.4) and the percent of those who had died was high (10--31%). Average height of the mothers was 149 cm and weight 42 kg. A cross-sectional calculation of weight gain during pregnancy resulted in 5.0--7.4 kg. Lactating mothers showed a higher weight-height ratio than non-lactating or pregnant. Taking 90% of the Indonesian standard of weight-for-height as cut-off point for an acceptable nutritional status, 18--24% of the nonpregnant non-lactating, 13--35% of the lactating and 33--57% of the pregnant mothers fell below that standard. Considerable and rather unexpected differences existed between regencies. Low percentages of illiteracy and highest of child survival were found in an area designated as 'minus' for per capita income and food production. Only in Sidoarjo was rice the most frequently consumed staple food. In Trenggalek (south coast) and in Sampang (Madura) it was cassava. In Blitar (south coast) it was rice, maize and cassava mixed or varying according to season. In the remaining six regions a mixture of rice and maize was the common food.

Adolescent↗

Novobiocin resistance and virulence of strains of Staphylococcus saprophyticus isolated from urine and skin.

A method was developed to study virulence of coagulase-negative staphylococci. Our results showed that coagulase-negative staphylococci injected into adult mice by the intracerebral route did not give rise to lethal infections, whereas mice aged 2 days were much more susceptible. Novobiocin-resistant strains of Staphylococcus saprophyticus were more virulent than strains of Staphylococcus epidermidis. Strains of S. saprophyticus biotype 3 of Baird-Parker's classification varied in virulence according to novobiocin sensitivity. In the classification of Kloos and Schleifer, S. saprophyticus biotype 3 can be subdivided into four distinct staphylococcal species, namely S. saprophyticus , S.cohnii, S.haemolyticus and S.warneri. S. chonii and S. saprophyticus were equally virulent for mice aged 2 days, but novobiocinsensitive S. haemolyticus was less virulent. On epidemiological grounds, however, it would seem that S. saprophyticus has some undefined advantage in invading the urinary tract.

Animals↗

Feeding practices, nutritional status and mortality in pre-school children in rural East Java, Indonesia.

During the dry season of 1975 and 1976 two nutrition surveys were carried out in nine regencies of the province of East Java, Indonesia. The objective was to assess the geographical prevalence, magnitude and severity of nutritional deficiencies, especially among mothers and children. In this paper childfeeding practices, nutritional status of pre-school children and child mortality are reported. In the rural areas surveyed breastfeeding is commonly practiced for a prolonged period. In the regencies along the south and north coast of East Java 90%, respectively 94% of children aged 19-24 months were still breastfed; in Sidoarjo, a relative 'surplus' area, the corresponding figure was 73% and on the island of Madura 51%. Even in age-group 25-47 months 34% still were nursed in Blitar-Trenggalek regency, 54% in Tuban-Lamongan, 23% in Sidoarjo and 15% in Madura. The variation in the breastfeeding period between the regencies is a matter of further investigation. In these rural areas the roles as competitor of powdered milk is a minor one. It was intriguing that 9% of the pregnant women still nursed their youngest child. Supplementary food was introduced at a very early age, i.e. in the first week. This was, however, insufficient to maintain adequate growth after the age of six months. According to weight-for-age severe malnutrition was diagnosed in respectively 1%, 4% and 10% of age-groups 0-5 months, 6-11 months and 1-3 years. The anthropometric data suggest that lack of calories is more influential than the deficit in protein. Age-specific mortality, according to age at death was about 21% in the perinatal and 16% in the neonatal period; from 1-11 months (inclusive) it was 31%, from 1.5 years 19% and till 12 years 8%.

Age Factors↗

Evaluation of the Vitatron "AKES" modification for optimal use in routine enzyme analysis.

The Vitatron has been used as designed by the manufacturer under routine laboratory conditions (Broughton, P.M.G., Buttolph, M.A., Gowenlock, A.H., Neill, D.W. and Sleutelberg, R.G. (1969) J. Clin. Pathol. 22, 278). We assessed the possibilities of the AKES with regard to determination of the activities of three enzymes: alanine transaminase (AIT), aspartate transaminase (AsT) and lactate dehydrogenase (LDH) in serum. Precision, accuracy, carry over and sample-diluent contamination were evaluated. This resulted in recommendations for optimal use in terms of capacity and precision, which were supported by computations on a mathematical model for measuring results.

Alanine Transaminase↗

Low birth weight babies under village conditions: feeding pattern, growth and motor development.

Feeding, growth and motor development of low birth weight babies (LBW) were assessed among infants born from September 1982 through December 1984 in 3 villages in Madura. Mean birth weight of Madurese infants ranged from 2850-2950 g and the incidence of LBW from 9.5-12.2%. A larger percentage of the very small LBW babies (birth weight 2.0-2.2 kg) received breastmilk as the sole food in the first 6 months. Yet, force-feeding was also practiced for LBW babies. Infants remained in their growth channel according to birth weight, however, relative to the NCHS centiles at birth, LBW infants grew better in the first 6 months than normal birth weight (NBW) infants. Growth deteriorated conspicuously in the second half of infancy, irrespective of birth weight. There was no difference in motor development between LBW and NBW infants. Once they had survived, LBW infants appeared to do as well as NBW under village conditions.

Birth Weight↗