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Biomedical subjects

C Defilippi

Publications and source records attributed to C Defilippi.

At least 37 records · Page 2Linked to original sources

[Sequential endovenous angiourography (AUS) with image subtraction for the study of the arterial phase of urography. Comparison with nephroangiotomography (NAT)].

Two urographical techniques employed in the endovenous study of renal arteries are compared. They are nephroangiotomography (NAT) using synchroplan and sequential angiourography (SAV) with image subtraction. 64 patients were studied, 32 with NAT and 32 with AVS. Both techniques were shown to be useful, but AVS through infrequently used was cleary more efficient than Nat in the study of the vascular arterial phase.

Adult

[Instrumental follow-up of patients treated by internal biliary drainage].

The various radiological techniques available for the long-term follow-up of patients given definitive percutaneous trans-hepatic biliary implants (DTBI) are evaluated on the basis of personal experience. After a rapid examination of the available technics it is concluded that direct X-ray, echotomography and sequential hepatobiliary scintigraphy are more than sufficient for an accurate follow-up of the disease in such patients.

Cholangiopancreatography, Endoscopic Retrograde

[Proposal of an echotomographic method of guided portal catheterization].

To identify the frontal plane on which to find the right branch of the portal vein in 33 patients who underwent transhepatic percutaneous portography, we used a real-time ultrasonic scanner improved with an original device conceived for this specific need. The suggested method reduced the number of the ineffectual punctures of the liver, allowing in nearly all cases the cannulation of the right branch on the first attempts.

Adult

Pancreatic secretory response to sham feeding in humans.

We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase pancreatic bicarbonate or amylase secretion above basal values. During a background secretin infusion, there was a significant increase of bicarbonate and amylase output (p less than 0.05) during sham feeding. The amylase response was approximately 50% of the maximal response to cholecystokinin octapeptide. In the tests with atropine and secretin, sham feeding still caused a significant increment in amylase and bicarbonate output. We conclude that (1) the pancreatic response to sham feeding is not clearly demonstrated without a background of secretin; (2) during secretin infusion sham feeding is a potent stimulant of pancreatic enzyme secretion, and (3) atropine had no significant effect on the pancreatic response to sham feeding under the conditions of this study.

Adult

Sham feeding disrupts the interdigestive motility complex in man.

We have examined the effect of sham feeding on the interdigestive motility complex (IDMC) and the release of pancreatic polypeptide (PP) in a group of normal volunteers. The duration of the intervals in phase III of the IDMC was significantly delayed (p less than 0.01) after sham feeding, whereas there was an increase in plasma PP levels in all subjects. These results support the presence of an inhibitory vagal mechanism for the distal stomach and intestinal motility.

Adult

Nonsteroidal antiinflammatory drugs: effect on pyloric sphincter and duodenogastric reflux.

We have investigated the effect of nonsteroidal antiinflammatory drugs on canine pyloric sphincter pressure, mucosal potential difference (PD), and duodenogastric reflux in 5 dogs. Only intragastric aspirin at doses of 30 and 100 mg/kg caused a significant (P less than 0.05) decrease in pyloric sphincter pressure, an increase of duodenogastric reflux, and changed the mucosal PD. Neither intravenous aspirin, intragastric phenylbutazone, or intrarectal indomethacin produced these changes. The mechanism for the aspirin effect may be mediated by local pathways related to changes in mucosal PD. We postulate that increased duodenogastric reflux may be an aggravating factor for the gastric mucosal damage caused by intragastric aspirin.

Animals

Effect of dopamine on human gastric and pancreatic secretion.

It has previously been shown that dopamine stimulates pancreatic exocine secretion and inhibits acid secretion in the dog. In this study, the authors have investigated the effect of dopamine on human gastric and pancreatic secretions. In 6 subjects, dopamine produced a dose-dependent inhibition of pentagastrin-stimulated acid secretion, an effect that was suppressed when the subjects received haloperidol. In 6 other subjects, dopamine infusion did not modify basal pancreatic secretion, and dopamine inhibited pancreatic enzyme secretion during secretin-cholecystokinin infusion. Dopamine also caused a rise in plasma glucagon and insulin. The effects on pancreatic enzyme secretion and plasma glucagon were not antagonized by haloperidol. The results suggest that dopamine is inhibitory for human gastric secretion. The authors did not observe a stimulatory effect of dopamine on human pancreatic exocrine secretion as has been observed in dogs.

Adult

Pyloric-sphincter studies in peptic-ulcer patients: pylorus in peptic ulcer.

Pyloric pressure was assayed by a manometric procedure in the basal state and after intraduodenal infusion of HCl. 13 control subjects, 11 patients with benign gastric ulcer, 8 with duodenal ulcer, and 2 with coexistent gastric and duodenal ulcers were studied. Mean resting pyloric pressure in gastric-ulcer patients (5.17 +/- 0.71) mm Hg) was significantly lower than controls (9.40 +/- 0.85 mm Hg) and did not increase after HCl perfusion into the duodenum. Mean basal pyloric pressure in duodenal-ulcer patients (11.30 +/- 1.57 mm Hg) did not differ significantly from controls and increased after intraduodenal perfusion of HCl to 15.72 +/- 2.40 mm Hg. The two patients with coexistent ulcers had manometric patterns similar to gastric-ulcer patients. Decreased pyloric-sphincter pressure in gastric-ulcer patients may be the mechanism responsible for the increased duodeno-gastric reflux observed in these patients.

Adolescent

Manometric studies on the human pyloric sphincter. Effect of cigarette smoking, metoclopramide, and atropine.

Pyloric sphincter pressure was assessed with water-perfused polyvinyl tubes. Smoking one cigarette significantly decreased the basal pyloric pressure, whereas 10 mg of metoclopramide as an intravenous bolus increased the pyloric pressure in normal subjects and in patients with gastric ulcer with low basal pressure. Duodenal acidification with 0.1 N HCl significantly increased pyloric pressure. Atropine 15 mug per kg, subcutaneously prevented the rise of pyloric pressure in response to acid infusion into the duodenum.

Adult

Effects of iopamidol on neonatal thyroid function.

The effects of Iopamidol on neonatal thyroid function have been investigated. Since the basic molecule is non-ionic, thyroid function is not damaged, even when large quantities of contrast media are employed.

Female

[Clinical considerations on 2 cases of hepatic fascioliasis. Importance of the imaging examinations].

Two cases of hepatic human fascioliasis, both with antecedents of eating watercress, hepatobiliary symptoms and high eosinophilia are described. In the first one (42 year-old male), at the beginning the abdominal ecotomographical and computed tomography images suggested an hepatic tumor, but afterwards, the finding of Fasciola hepatica ova in feces and the observation of numerous typical images of the fluke in the choledochus by means of an endoscopic cholangiography, plus lesions related to a Löffler syndrome detected in a chest radiography, lead to the diagnosis of hepatic fascioliasis. The patient was treated with dehydroemetine. In the second case (52 year-old male), presented pain in the upper right abdominal quadrant; in an abdominal ecography three cystic lesions in the right liver lobe were found. Nor in the feces neither in the bile F. hepatica eggs were observed. Serological tests for fascioliasis and hydatidosis resulted positive. The endoscopic cholangiography was normal. With the presumptive diagnosis of fascioliasis the patient was treated with dehydroemetine. But as his disturbances remained during the following six months, and raising the possibility of a suppurated hydatid cyst or hepatic abscesses, he was submitted to surgery, finding F. hepatica eggs in the chocolate-like hematic liquid. In the wall and in a liver mass resected a grunuloma with eggs of the parasite was detected. The patient was treated again and cured with dehydroemetine. The existence of subcapsular hematomata and granulomas in hepatic fascioliasis, which can give raise to a diagnosis confusion due to their aspect in the ecotomography and computed tomography are commented. The cholangiographic aspect of the affection is discussed.

Adult