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Biomedical subjects

C Del Vecchio-Blanco

Publications and source records attributed to C Del Vecchio-Blanco.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Comparative study of the plasma levels of alpha-1 fetoprotein and carcinoembryonic antigen in chronic liver diseases and malignant neoplasias (author's transl)].

We have measured the plasma levels of alpha-1 fetoprotein (AFP) and carcinembryonic antigen (CEA) by RIA in 98 chronic liver diseases (20 chronic aggressive hepatitis and 75 cirrhosis), in 46 subjects with several varieties of malignant neoplasias and in 30 normal controls. In cirrhosis levels higher than the media +/- 2 DS of controls were found in 25.3% for AFP (Max. value 250 ng/ml) and in 36.0% for CEA (Max. value 150 ng/ml). Only in 6 cases of cirrhosis we found high levels of AFP and CEA contemporaneously. High levels of AFP were found in 10/13 primary liver cancers and only in 1 patient with colonic carcinomata. High levels of CEA were found in 4/13 primary liver cancers (1 AFP positive too), 3/4 metastatic liver cancers, 7/17 colonic primary cancers, 3/6 bronchogenic carcinoma, and 3/6 other malignancies.

Adolescent↗
PubMedDate not supplied

The significance of the HBe system in an area highly endemic for hepatitis B virus.

A group of 164 consecutive patients with chronic liver disease and 60 healthy HBsAg carriers were investigated in an area highly endemic for hepatitis B virus (HBV). Eighty-two of the 164 patients (50%) were found to be HBsAg-positive and only 39 (24%) had no HBV markers. A statistically significant correlation was found in the HBsAg-positive patients between the HBe system, their age and the time which had elapsed since their acute episode. Thus, the prevalence of HBeAg decreased with increasing age and with increasing time since their acute episodes. Furthermore, a statistically significant correlation was found between the presence of HBeAg and active chronic liver disease. Of the patients with chronic active hepatitis with or without cirrhosis, all patients below the age of 13 years were HBsAg-positive and 72% were also HBeAg-positive. The data suggest that the HBeAg-positivity in HBsAg carriers is of limited duration and that the seroconversion from HBeAg to anti-HBe is related to a histologically less active or inactive stage of the disease.

Adolescent↗