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Biomedical subjects

C Desloovere

Publications and source records attributed to C Desloovere.

18 recordsLinked to original sources
PubMed2006

Hyperbaric oxygen therapy after failure of conventional therapy for sudden deafness.

PROBLEMS/OBJECTIVES: We investigated the effect of secondary hyperbaric oxygen therapy (HBO) for patients with idiopathic sudden sensorineural hearing loss after unsuccessful conventional treatment. METHODOLOGY: We retrospectively evaluated 3 groups: 100 patients without further treatment (group 1), 160 patients with secondary HBO at 1.5 ATA (group 2), and 56 patients with secondary HBO at 2.5 ATA (group 3). RESULTS: In group 1, a mean hearing gain (MHG) of 2.6 +/- 15 dB was found at the end of the follow-up period. After HBO, a MHG of 3.1 +/- 9 dB in group 2 and 19.7 +/- 23 dB in group 3 was achieved. The results in group 3 were statistically significant in comparison to group 1 (p < 0.007) and to group 2 (p < 0.009). With HBO after initial therapy failure, there is a significant correlation of MHG with time delay before HBO (p < 0.03). CONCLUSIONS: HBO at 2.5 ATA in patients with idiopathic sudden sensorineural hearing loss after unsuccessful conventional treatment yields significant improvement of hearing. MHG is higher when time delay before HBO is shorter.

Adolescent↗
PubMed2005

Management of otitis media with effusion in children.

Otitis media with effusion in children: B-ENT Guidelines. OME is highly prevalent among young children, with peak prevalences at around two and five years of age. Although serious complications are rare, the burden of OM is large with impaired quality of life and high direct and indirect socio-economic costs. To date, medical treatment of OME is not recommended because of the limited scientific evidence that this treatment is effective in the long term. Surgical candidacy for OME depends largely on hearing status, associated symptoms, the child's developmental risk and the anticipated chance of spontaneous resolution of the effusion. Ultimately, the recommendation for surgery must be individualized.

Acoustic Impedance Tests↗
PubMed2004

2',5'-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis.

OBJECTIVE: Determination of early prognostic factors in patients with recurrent respiratory papillomatosis is extremely important, so the major goal of our prospective, multicentre study was to evaluate (1) the feasibility of various factors to determine prognosis of the clinical course, as well as (2) the response to interferon-alpha therapy in recurrent respiratory papillomatosis. METHODS: Forty-two patients with recurrent respiratory papillomatosis were treated with interferon-alpha (3 MU/m(2) three times per week; mean therapy duration was 2.7 +/- 1.8 years) in 1983-1994 and followed-up until 2003. Human papilloma virus (HPV) type, recurrent respiratory papillomatosis severity and 2',5'-oligoadenylate synthetase activity were determined by standard methods and analysed for correlation with the results of long-term clinical outcome. RESULTS AND CONCLUSION: Patients with HPV type 11, a severity score >4, a high number of surgical procedures prior to interferon-alpha therapy and a high basal 2',5'-oligoadenylate synthetase activity should be considered at high risk of an aggressive clinical course, often with spread to lower airway passages, malignant transformation and death. Human papilloma virus type, score for recurrent respiratory papillomatosis severity, number of surgical procedures and 2',5'-oligoadenylate synthetase activity showed significant association with response to interferon-alpha therapy and the long-term clinical course, so these factors have value in predicting prognosis in recurrent respiratory papillomatosis.

2',5'-Oligoadenylate Synthetase↗
PubMed2004

Jugular foramen schwannoma: surgical experience in six cases.

PURPOSE: Schwannomas of the lower cranial nerves are rare tumours. We have surgical experience in six patients. MATERIAL AND METHODS: We have retrospectively reviewed the files of the six patients with jugular foramen schwannomas that were treated in multidisciplinary collaboration in the departments of neurosurgery and ENT. RESULTS: From a clinical point of view, the most important finding was that these tumours usually mimic a vestibular schwannoma. The imaging findings however always allowed the differentiation. The surgical technique included in all cases a suboccipital approach for the intracranial part. When large, the extracranial extension had to be removed through a lateral cervical or transfacial approach. There was no mortality and minor morbidity, with good functional outcome. In subtotally removed tumours, recurrence occurred. CONCLUSION: A combined neurosurgical and ENT approach allows for safe removal of these often large skull base tumours.

Adult↗
PubMed1999

[Halitosis--foetor ex ore].

BACKGROUND: An overview is presented on the etiology, diagnosis, and therapy of halitosis. METHODS: Results are given of our multidisciplinary halitosis outpatient department started in 1994. The team consists of ENT specialists and paradontologists, occasionally assisted by a psychiatrist. The oral odor is confirmed with a halitometer (Interscan Corporation, Model RH-17E USA). 491 Patients, nearly the same number of males as females, mostly between 20 and 50 years of age were seen. RESULTS: Oral causes (87%) were due to tongue coating (51%), gingivitis (17%), paradontitis (15%), or combinations of factors (17%). The other 13% involved causes related to ENT problems (4%), both ENT and oral (3%), digestive tract (1%), and presumed psychiatric pathology (5%). CONCLUSIONS: Many patients underwent diagnostic and therapeutic aimed interventions to no avail prior to their arrival in our halitosis clinic. Usually advising the patient to maintain better oral hygiene is sufficient.

Adolescent↗
PubMed1998

Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].

Respiratory papillomatosis is a rare and often severe disease, usually localized in the larynx. It may cause respiratory distress and even life-threatening obstruction of the airways. Treatment is generally based on the evaporation of the lesions with a CO2 laser, but microsurgery, cytotoxic and/or cytostatic drugs, interferons, and vaccines are also used. Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] (HPMPC) was shown to suppress the growth of tumors induced by rabbit papillomavirus as well as human papillomavirus (HPV). The efficacy of cidofovir was assessed in 17 patients with severe respiratory papillomatosis. Cidofovir at a concentration of 2.5 mg/ml was injected directly in the different laryngeal papillomatous lesions during microlaryngoscopy under general anesthesia. Biopsies were taken before the treatment was started both for anatomopathology and viral typing. HPMPC kinetics in serum was monitored in three patients, the drug levels being determined by high-performance liquid chromatography. Complete disappearance of the papillomatosis was observed in 14 patients. Four patients relapsed and were successfully treated again with cidofovir. Of the three remaining patients, one progressed while under treatment with cidofovir, after an initial marked response. One patient had a partial remission and remained stable for more than 1 year after the last injection. He had a very aggressive and extensive disease originally. Finally, one patient was lost to follow-up after four injections. Intratumoral injections of cidofovir for the treatment of severe laryngeal papillomatosis is a powerful new therapeutic approach for this disease. Treatment was well tolerated, and no significant side effects were noted.

Adolescent↗
PubMed1998

Cochlear implantation: past and present.

Experimental stimulation of the ear started at the end of the 18th century with Volta. The first electrode implantation was performed by Djouno and Eyries in 1957. This was followed by intensive cochlear implant research at first in California, then all over the world. During the past 2 decades there has been an evolution from single to high performance multichannel implants with the development of more sophisticated speech coding strategies.

Cochlear Implantation↗
PubMed1997

Labyrinthine fistulae: a retrospective analysis.

A retrospective analysis has been conducted of 57 labyrinthine fistulae found in 375 cholesteatoma cases, primarily treated by removal of the matrix of the cholesteatoma and covering the fistula with a mixture of bone paste and fibrin glue. CT-scan with slices of 1 mm demonstrated the fistula in almost 90% of the cases. Eighteen percent of the ears were pre-operatively totally deaf. Large fistulae are riskier than smaller ones for post-operative perceptive losses, but even in very large and multiple fistulae the hearing may be preserved in most cases.

Bone Cements↗
PubMed1996

A follow-up study of long-term results after cochlear implantation in children and adolescents.

The time course of speech development in children after cochlear implantation may extend over many years, thus making long-term studies necessary to evaluate any outcome. We report our long-term results after cochlear implantation in children and adolescents. Mean follow-up was 28 months, ranging from 1 to 5 years. After at least 1 year of experience all children were found to benefit from their cochlear implants. The majority of children scored above chance in speech identification tasks requiring closed set word and sentence understanding). At the 4-year interval, all children tested including prelingually deaf children had developed open set sentence understanding. The most relevant factor accounting for differences in the results was the duration of implant use in all groups. Even beyond 3 years the results continued to improve. Peri- or postlingually deafened children tended to have favorable results. For prelingually deaf children, duration of deafness and age at implantation were correlated negatively with the results.

Adolescent↗
PubMed1995

[Infusion therapy in sudden deafness. Reducing the risk of pruritus after hydroxyethyl starch and maintaining therapeutic success--a prospective randomized study].

A Prospective Randomized Study: The aim of the study was to demonstrate the effectiveness of two different treatment schemes with hydroxyethyl starch (HES) and the incidence of pruritus as a side effect in a population of patients with sudden sensorineural hearing loss and hematocrit values above 44% and/or hemoglobin values above 14 g/dl. Under these circumstances we found a significant hearing improvement with infusions of 500 ml 10% HES 200/0.5 compared to saline infusions in a previous double-blind placebo-controlled study. Two groups are compared in a prospective randomized study. Group 1 was treated with infusions of 250 ml 10% HES 200/0.5 and group 2 with 500 ml of the same substance (n = 200). No difference in hearing improvement was detected between the two groups. The results were significantly better than with saline infusions. Eleven percent of the patients in group 1 developed pruritus and 38% in group 2. The incidence of pruritus correlated with the cumulative dosage of HES given. A correlation between allergic disposition and pruritus could not be found. Therefore, we suggest infusions with 250 ml 10% HES 200/0.5 per day for patients with sudden sensorineural hearing loss and hematocrit values above 44% and/or hemoglobin values above 14 g/dl. Indications for a long lasting HES-therapy should be restrictive. The effectiveness of HES has not been yet demonstrated in patients with lower hemoglobin and hematocrit values.

Auditory Threshold↗
PubMed1991

[Clavicular fractures after radical neck dissection].

Fracture of the medial end of the clavicle as a late complication following radical neck dissection is rare, with an incidence of approximately 0.4%-0.5%. Radical neck dissection alters the mechanics of the shoulder girdle, and distorts normal muscle forces acting on the clavicle. We present two patients to illustrate the problems of differential diagnosis and mechanism of fracture. Once the diagnosis has been made the fracture should be managed conservatively, although clinical and radiological differentiation from avascular necrosis or bony metastasis may be difficult. Biopsy is essential in doubtful cases.

Adult↗
PubMed1989

Sudden sensorineural hearing loss influence of hemodynamical and hemorheological factors on spontaneous recovery and therapy results.

The effect of a hemodilution therapy for sudden sensorineural hearing loss was analysed comparing the results of a prospective randomised double blind study and a retrospective study at the Frankfurt university. The prospective study consists of a treatment group receiving infusions with hydroxyethyl starch-pentoxifyllin and a control group with infusions with normal saline. Another patient group receiving hydroxyethyl starch-pentoxifyllin-naftidrofuryl infusions was analysed retrospectively. The overall therapy results are in the same range for all 3 groups. However patients with a hemoglobin value above 14 mg % in the control group had a poorer result compared to the other groups. The patient group with systolic blood pressure above 130 mm Hg treated with hydroxyethyl starch-pentoxifyllin had a significant hearing improvement over normal saline and hydroxyethyl starch-pentoxifyllin-naftidrofuryl. With increasing systolic blood pressure, patients in the control and hydroxyethyl starch-pentoxifyllin-naftidrofuryl groups had a statistically significant lower therapy result.

Acute Disease↗
PubMed1989

Radiosensitizing with cis-platin in advanced head and neck cancer. Results and problems.

Treatment consisting of surgery and/or radiation therapy for patients with squamous cell carcinoma of the head and neck has frequently been successful in earlier stages of disease. Advanced and non-resectable tumor stages have a very poor cure rate. We initiated this trail to assess the role of the potentiation between cis-PDD and radiation previously reported in advanced head and neck tumors. Eighteen patients were investigated in this study. The treatment consisted of cis-PDD and hyperfractionated radiotherapy. Seventeen (94%) of the patients responded to the treatment regimen with either a complete regression (5/18 = 33%) or a partial regression (11/18 = 61%) of the tumor. Median survival was short and lasted 12+ months among complete responders and 8+ months among partial responders. However all patients did experience an increased and not tolerable incidence of delayed radiation toxicity such as mucositis combined with necrotic stomatitis. Both complications limited the compliance to the therapy. Because of these complications we had to stop the ongoing study.

Adult↗
PubMed1989

Proliferation-associated monoclonal antibodies: a useful tool for prognosis in squamous cell carcinomas of head and neck?

Three different proliferation-associated monoclonal antibodies have been studied immunohistochemically to evaluate their prognostic value in patients with squamous cell carcinomas of head and neck. The monoclonal antibody Ki 67 shows a heterogeneous distribution pattern, whereas epidermal growth factor receptor and transferrin receptor expression show a homogeneous one. Concluding from our results the chances to use the described monoclonal antibodies as prognostic markers are limited.

Antibodies, Monoclonal↗
PubMed1988

[Randomized double-blind study of therapy of sudden deafness: initial results].

Three treatment groups (hydroxyethyl starch-pentoxifylline (HAES-steril/Trental), hydroxyethyl starch-pentoxifylline-naftidrofuryl (HAES-steril/Trental/Dusodril) and dextran-pentoxifylline (Rheomacrodex/Trental] and a placebo therapy control group (normal saline) were compared in a prospective randomised study (102 patients) and a retrospective study (292 patients). The trial therapy results were the same in all groups. However all treatments on patients with a haemoglobin greater than 14 g/l result in a significant hearing improvement compared with the placebo. The patient group with systolic blood pressure greater than 130 mm Hg treated with hydroxyethyl starch-pentoxifylline had a significant hearing improvement compared with the placebo, hydroxyethyl starch-pentoxifylline-naftidrofuryl and dextran-pentoxifylline. With increasing systolic blood pressure, patients in the placebo, hydroxyethyl starch-pentoxifylline-naftidrofuryl and dextran-pentoxifylline groups had a statistically significant worse result.

Adolescent↗
PubMed1988

[Mini-plate osteosynthesis in zygomatic fractures--restoration or alternative?].

At the University ENT Clinic Frankfurt 105 patients with zygomatic fractures were treated from 1980 until 1986: 45 were treated with a maxillary sinus stent, part of them in combination with wire osteosynthesis, miniplate osteosynthesis was performed in 30 patients, some fractures seemed stable after reposition without fixation. The zygomatic fractures are classified into 3 types requiring different surgical treatments. Comparing the long term results of these methods with the pre- and postoperative radiological and functional data, patients with type 2 and 3 fractures do better with miniplate osteosynthesis than with the other treatments. In combination with an orbital floor fracture, the degree of enophthalmus is more severe in those patients where fractures were only repositioned without fixation.

Bone Plates↗