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C Diago

Publications and source records attributed to C Diago.

6 recordsLinked to original sources
PubMed1999

Patients with poor preoperative ejection fraction have a higher plasma response of adrenomedullin in response to open heart surgery.

BACKGROUND: Adrenomedullin (AM) is a potent vasodilator peptide. Plasma AM levels are increased in heart diseases and in sepsis. Heart surgery under cardiopulmonary bypass (CPB) induces a systemic inflammatory response. METHODS: We measured plasma AM, cAMP (the second messenger of AM), C-reactive protein (CRP) and haemodynamic parameters in 29 patients undergoing elective open heart surgery, before, during and after anaesthesia and CPB as well as on the first morning after surgery. RESULTS: Basal AM levels were higher than normal and correlated with systolic pulmonary pressure and pulmonary capillary pressure, but not with other haemodynamic parameters. AM increased during CPB and remained elevated 24 h after the start of surgery. Plasma cAMP increased only at the end of CPB. CRP was increased only in the last sample. At the end of CPB and at the end of surgery AM levels were higher in patients with basal ejection fraction<40% compared with those with ejection fraction >60% [456+/-386 vs 252+/-343 (P<0.03) and 832+/-781 vs 391+/-356 pg/ml (P<0.05), respectively]. CONCLUSION: We conclude that AM, as inflammation-related cytokines, increases during and after CPB, that cAMP response is unrelated to AM and that AM response is higher in those patients with worse basal ejection fraction.

Adrenomedullin↗
PubMed1987

Carcinoid syndrome and intravenous cyproheptadine.

The anaesthetic management of a patient with the carcinoid syndrome is reported. Important cardiovascular complications occurred immediately after tracheal intubation and during manipulation of metastases. Hypertensive crises were controlled with intravenous cyproheptadine, although hypotension and drowsiness were observed due to its use.

Aged↗
PubMedDate not supplied

[Perioperative response of phosphorus and calcium metabolism and of bone remodeling markers during heart surgery under extracorporeal circulation].

HYPOTHESIS AND OBJECTIVES: Cardiovascular surgery with extracorporeal circulation (ECC) is highly stressful, inducing marked changes in calcium and magnesium homeostasis. Nevertheless, no studies have assessed osteoblastic/osteoclastic activity during and after heart surgery with ECC. Our objective was to analyze changes in serum levels of parameters reflecting phosphorus and calcium metabolism and markers of bone remodelling in this context. PATIENTS AND METHODS: Changes in serum levels of calcium, phosphorus, whole parathyroid hormone (PTH), magnesium, cortisol, interleukin-6, total alkaline phosphatase, osseous alkaline phosphatase (OAP), osteocalcin, propeptide of type 1 procollagen (PCP1), and carboxyl-terminal telopeptide of type 1 collagen (CTT1) during the 24 perioperative hours in 16 patients undergoing cardiac surgery with ECC. RESULTS: Total calcium decreased during ECC, triggering acute release of PTH. Osteocalcin decreased at 24 hours in a way that was not accounted for by hemodilution. OAP changes, on the other hand, were consistent with albumin levels and blood cell counts. PCP1 and CTT1 did not change, although correcting for dilution shows that these factors can in fact be considered to have increased. CONCLUSIONS: The parathyroid gland is activated during ECC. Markers of bone metabolism behave differently over time in response to heart surgery. The data suggest that heart surgery induces discordant responses in various bone cell functions.

Adult↗