Rosacea: a reply to Wilkin's reply.
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Diagnosis, Differential↗
Biomedical subjects
C Divano
Publications and source records attributed to C Divano.
Flushing in rosacea: a possible mechanism.
Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.
Adult↗
Soluble and insoluble collagen and elastin in the rat hair cycle.
Soluble and insoluble collagen and elastin were chemically evaluated in the dorsal skin of rats during the third hair cycle. Both fractions of collagen remain unchanged during anagen, while they increase considerably in the first days of telogen to drop afterwards. Elastin content gradually increases throughout anagen and falls in telogen. The authors suggest that the increasing amounts of collagen in the first part of telogen may be responsbile for the progressive block in the downwards movements of previously growing follicles into the dermis. Elastin data could be the result of a mechanical readjustment of skin to the expansion provoked by growing follicles.
Animals↗
Preliminary clinical evaluation of a new topical corticosteroid, halopredone acetate, as compared to fluocinonide.
17,21-Bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), a new corticosteroid for topical use, was compared with fluocinonide in a double blind sequential study. The tests were made on a total of 16 patients affected with psoriasis and exudative dermatitis. In each patient, the symmetrically distributed skin lesions were separately treated with either halopredone acetate or the reference compound. The two active substances were in the same concentration (0.05%) in the same carrier (cream), and both reduced the subjective and objective symptoms of these skin conditions. No statistically significant differences were observed between the two medicated areas. Haloperidone acetate, the excipients of the cream and the reference compound were all excellently tolerated.
Administration, Topical↗
Clinical study of the relationship between dose and response to halopredone acetate in dermatoses.
A comparative clinical investigation with three different concentrations of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), a new topical corticosteroid, has been made to assess the optimum concentration of active substance to be incorporated into cream on the basis of the therapeutic effects achieved in dermatologic patients. The remarkable therapeutical effectiveness of the new steroid, however, has made it impossible to ascertain statistically significant differences between preparations containing either 0.01%, 0.025% or 0.05% of active substance, and to gain thereby a clear answer concerning the relationship between dose and response. Numerous haematochemical controls were made during the trials. In particular, we determined the plasma cortisol levels in patients suffering from large lesions requiring prolonged occlusive medication. No significant alterations of the basal values were observed. As already observed in animals, halopredone, acetate is devoid in humans also of the wellknown effects on the hypophysial-adrenal axis due to transcutaneous absorption of steroids.
Administration, Topical↗
Studies on rat hair cultures. IV. The effects of testosterone and dihydrotestosterone.
By means of two different quantification techniques the Authors were able to show that the addition of increasing concentrations of testosterone to the medium of hair-cultures simultaneously provokes an increased volume of epidermis as well as of hair-follicles and a better differentiation of hair follicles. The addition of dihydrotestosterone, on the contrary, does not induce any change.
Animals↗
Adenyl-cyclase activity in rat-hair-cycle.
In the skin of rat, during telogen phase, a high adenyl-cyclase activity coincides with maximal catecholamines content, minimal histamine level and blocking of mitoses in epithelial cells. These events suggest that in telogen the control of mitotic activity in rat hair follicles may operate through a block of G1 cells as already suggested for epidermal cells.
Adenylyl Cyclases↗