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Biomedical subjects

C Dolisi

Publications and source records attributed to C Dolisi.

At least 37 records · Page 2Linked to original sources
PubMed1993

Brainstem auditory evoked potentials. Differences related to physical activity.

Shorter sensory-motor reaction times have been reported in athletes compared with sedentary subjects. Previous results have shown significantly shorter visual evoked potentials (VEPs) latencies in a group of tennis players, but there was no difference between a group of rowers and control subjects. In the present study, the same groups were investigated in order to establish whether similar differences could be found in relation to brainstem auditory evoked potentials (BAEPs). Waves I to V latencies (Ls), interpeak latencies (IPLs) and wave amplitudes were measured. The results showed great differences related to gender. The I-III IPL was shorter in the females than in the males. Differences were also found in relation to physical activity. The most important feature was the significantly shorter III-V IPL observed in the rowers and in the tennis players of both genders compared with sedentary control subjects. In the males these differences were linked to training factors. Therefore, unlike VEPs which seemed to be linked to sports requiring high visual acuity, BAEPs seemed to be linked more widely to top-class physical activity and not to specific sensory aptitude. It was hypothesized that the shorter III-V IPL might be due to shorter synaptic transmission time in the superior olivary complex.

Adolescent↗
PubMed1993

Interatrial conduction in patients undergoing AV stimulation: effects of increasing right atrial stimulation rate.

To evaluate the frequency of spontaneous or rate dependent interatrial blocks, the interatrial conduction time (IACT) was studied on 100 consecutive patients (mean age 78.3 +/- 7.8 years) during a transvenous dual chamber pacemaker implant. The spontaneous interatrial conduction time (SIACT) was measured from the intrinsic deflection (ID) of the unipolar right atrial signal to the ID of the left atrial signal recorded in a bipolar way by an esophageal lead. The paced interatrial conduction time (PIACT) was measured from the stimulus artifact to the left atrial ID, when the atrium was paced at a slightly higher rate than the spontaneous rate and during incremental atrial pacing. From these measurements, the maximum increase of PIACT (MIPIACT) was deduced. In this elderly population, the PIACT was similar (117 +/- 26.9 msec) to the data in the literature. However, there were large interindividual variations that were also found in SIACT. We found a close correlation between SIACT and PIACT (P < 0.0001). PIACT was on average 50 msec longer than SIACT. SIACT increased with age (P < 0.03). The MIPIACT was 15.3 +/- 15.2 msec. In the majority of patients, the MIPIACT was > 10 msec, and even reached 90 msec in one patient. MIPIACT was longer in patients with a PIACT exceeding 110 msec (P < 0.004). Based on IACT alone, the AV interval must be lengthened on average by 50 msec when changing from atrial tracking-ventricular pacing to atrial pacing-ventricular pacing, but large individual differences must be kept in mind. Elderly people should probably have a longer AV delay.

Aged↗
PubMed1992

'De novo' absence status of late onset: report of 11 cases.

Absence status (AS) is a heterogenous epileptic syndrome that can occur at any age, usually in a context of prior epilepsy. Eleven cases of AS occurring in middle-aged patients who had no history of epilepsy were retrospectively collected over a 10-year period (10 women and one man; mean age, 58.6 years). Eight patients were receiving high doses of psychotropic drugs. Clinical and EEG presentation was similar to AS occurring in patients with prior epilepsy. Evaluation of precipitating factors revealed that AS coincided with benzodiazepine withdrawal in eight cases. Cofactors included excessive use of other psychotropic drugs, nonpsychotropic treatment, hypocalcemia, hyponatremia, and chronic alcoholism. CT demonstrated mild cerebral atrophy in six cases. There was no recurrence, even without chronic antiepileptic treatment. These data indicate that (1) most cases of "de novo" AS of middle age or late onset result from the addition of various epileptogenic factors; (2) AS can be considered a new and uncommon complication of benzodiazepine withdrawal, and (3) long-term administration of anticonvulsant medication may not be required.

Aged↗
PubMed1991

Visual evoked potentials: differences related to physical activity.

Visually evoked potentials to patterned stimuli were recorded from tennis players, rowers and non-athlete control subjects. Each group consisted of 12 males and 12 females of similar age. Tennis players showed shorter P100 latencies compared to those of control subjects and rowers. This difference exists, in the same range, both in the male and in the females. The analysis of covariance and multiple linear regressions show that these shorter latencies cannot be explained by head circumference or by height. The hypothesis of a relationship between these shorter latencies and the specific qualities of racket players is suggested. A second experiment with squash players seems to confirm these first results.

Adolescent↗
PubMed1990

Quantitative EEG abnormalities and asymmetries in patients with intracranial tumors.

Quantified EEG data of 50 patients with intracranial tumors (T) were compared to the data profile of 60 normal adults (N), using univariate and multivariate statistical analyses. EEGs were recorded from 16 derivations. Twelve spectral parameters were computed from each lead and used for statistical comparisons. The number of significant deviations (P less than 0.05) among univariate features did not separate the T subjects from the N subjects with an acceptable sensitivity. A significant improvement was achieved by using multivariate features and particularly asymmetry multivariate features which detected 49/50 of the T subjects. The proportion of correctly lateralized tumors was 43/48.

Adult↗
PubMed1990

[Prolonged confusion syndrome in the course of cyclosporine treatment: a state of confusion?].

Cyclosporine is a potent immunosuppressant that is more and more widely used, particularly after organ transplantations. Many neurological side effects, including convulsions, that could be related to this drug, have been previously observed, most often with high blood concentrations. We report, for the first time, a case of prolonged confusion where a non convulsive status epilepticus may be discussed. It occurred in a 64-year-old woman, 17 days after a liver transplantation. The whole blood cyclosporine value was 230 micrograms/l (normal range: 100-200 micrograms/l) at the beginning of the status epilepticus. The cyclosporine imputability and the part of other factors that could have facilite are discussed.

Chronic Disease↗
PubMed1990

[A case of deep sleep myoclonus in newborn infants].

The authors report on the case of a newborn infant without pathological history suffering from severe and lasting myoclonus occurring during deep sleep and associated with normal electroencephalogram. Deep sleep myoclonus is a benign syndrome which disappears spontaneously within a few months. The long-term prognosis is excellent, but the etiology remains unknown.

Humans↗
PubMed1989

[EEG recorded after effort in triathletes. Influence of prior inhalation of hyperbaric oxygen].

Quantitative EEG was recorded during 3 sessions, once a week, in 10 high-level amateur triathletes, who regularly competed in triathlon. At each session, the EEG was recorded 15 min after a submaximal exercise test. During the second session, the exercise test came immediately after 30 min of hyperbaric oxygenation (100% oxygen at 2 atmosphere absolute pressure). The others conditions of the EEG recording were the same for the 3 sessions. The purpose of the work was to study the variations of the EEG power spectrum (from 1 to 20 Hz) which occurred between the 3 sessions. Descriptive analysis of the results show, after hyperbaric oxygenation, a diffuse increase of absolute power for several frequencies in the theta, alpha and beta bands.

Administration, Inhalation↗
PubMed1988

[Effects of positive expiratory pressure on cardiac output and estimated hepatic blood flow during controlled ventilation in man].

This study aimed to discover the effects of artificial ventilation with positive end-expiratory pressure (PEEP) on cardiac output and hepatic blood flow in ten patients with chronic stable post-anoxic or post-traumatic coma, without any cerebral oedema or any other visceral pathology. This study was carried out at four levels of end-expiratory pressure (0, 5, 12 and 29 cmH2O) and after 24 h of artificial ventilation with a PEEP arbitrarily fixed at 12 cmH2O. Cardiac output was measured by thermodilution and hepatic blood flow by applying Fick's principle on a continuous infusion of indocyanine green with an analysis of suprahepatic venous samples. Hepatic blood flow is given by the amount of indocyanine green infused (0.5 mg.min-1) divided by the difference between arterial and suprahepatic venous indocyanine green concentration. For all levels of PEEP, mean arterial, right atrial, wedge and suprahepatic pressures and hepatosplanchnic resistances were measured. Artificial ventilation with PEEP induced a fall of cardiac output and hepatic blood flow proportional with the increase in PEEP level. The fall in hepatic blood flow began to be statistically significant for a PEEP level of 5 cmH2O (-17%; p less than 0.01) and was maximum for a PEEP of 20 cmH2O (-49.51%; p less than 0.001). There was no linear correlation between cardiac output and hepatic blood flow: the fall in hepatic blood flow was more important than the fall in cardiac output. These changes in hepatic blood flow were accompanied by a significant increase in hepatosplanchnic resistances (p less than 0.01 for PEEP = 12 cmH2O), without any changes in other haemodynamic parameters or biological signs of hepatic disturbance.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

[Electrophysiological study of a family of subjects presenting primary hypertrophic neuritis].

Primary hypertrophic neuritis (hereditary motor and sensory neuropathy types I and III) can easily be characterized in affected families by nerve conduction measurement. Such a study is reported in a family with two affected subjects from two successive generations, a man and one of his daughters (type I). Nerve conduction velocities (NCV) were dramatically low (down to 10 m/sec) in three other subjects from the second generation without any obvious clinical symptom. These cases show again the lack of correlation between electrophysiological data and clinical features in these affections. They emphasize the usefulness of electrophysiological diagnosis among subjects without any obvious clinical sign.

Adolescent↗
PubMed1987

[Statistical EEG detection of subjects with intracranial tumors. Study of a sample of 40 quantified recordings].

Spectral analysis of 16 channel EEG recordings was applied to 40 normal subjects (N) and 40 patients with supratentorial intracranial tumor (T). A set of 22 spectral parameters was computed from each lead. This study tries to evaluate if univariate and multivariate scoring techniques of quantified EEG data can achieve good separation of the two groups. A reference profile of data is derived from the standardized data of the group N. The 40 patients as well as the 40 normal subjects are compared to the reference data profile. Scorings from 264 univariate features do not separate the two groups. Scorings from a smaller number of multivariate features proved to be more powerful and distinguished 90% of patients. Badly classified subjects are discussed.

Adult↗
PubMed1986

Effects of feeding time upon daily intake and body weight.

Feeding behavior in five dogs was studied in three experimental situations, called A, B and C. In situation A the dogs had free access to food and water. Results from this experiment were used to determine the times of high and low ingestion for each individual dog. In situation B, there was limited access to food during the dog's period of high ingestion, and in situation C there was limited access to food during periods of low ingestion. Daily food intake was found to diminish as the dogs proceeded from A and B to C, and was especially pronounced between A and C. Body weight also diminished significantly between A and C.

Animals↗
PubMed1985

[Effects of injectable flunitrazepam on hepatic and cardiac output in man].

The effects of intravenous flunitrazepam (0.03 mg X kg-1) on the estimated hepatic plasma output (DPHE), compared with the cardiac output (Q), were studied before its injection and 1 min afterwards. The question asked was whether the decrease in venous return led to a fall in hepatic perfusion. This study was made on patients in neurological coma without any organic lesion. The DPHE was measured by applying Fick's principle, using a continuous infusion of indocyanine green (ICG). The DPHE was given by the amount of ICG perfused in mg X min-1 divided by the arterial concentration of ICG less the concentration of ICG in the hepatic vein (in mg X 1(-1)). Cardiac output was measured by thermodilution. Flunitrazepam did not significantly modify either DPHE or Q; they fell by 5.6% and 3.4% respectively. None of the seven cardiovascular parameters changed during the time of the study. Thus, in unconscious patients with satisfactory haemodynamic conditions prior to the intravenous injection, flunitrazepam did not significantly modify hepatic perfusion.

Adolescent↗
PubMed1981

[Effects of dopamine on cardiac and hepatic index in man (author's transl)].

Dopamine is known to increase cardiac output and, to a greater extent, renal blood flow. The purpose of this study was to find out whether renal blood flow is increased partly at the expense of splanchnic blood flow. The splanchnic blood flow was evaluated by measuring, according to Fick's principle, the estimated liver blood flow during a continuous infusion of indocyanine green. Each determination was coupled with a measurement of the cardiac output, using a thermodilution method. The results were corrected to body surface, thus providing a cardiac index (Cl) and a hepatic index (Hl). The study involved 10 subjects free from hepatic, haemodynamic or haemorrhagic disease and was carried out in 3 stages: determination of initial values, then of values under dopamine (10-12 micrograms. kg. min) and finally, control of return to initial levels. The results showed that dopamine produced a significant (p less than 0,01) increase in Cl (mean 44%) and an equally significant (p less than 0,01) increase in Hl (mean 66%), the difference between the two increases being also significant (p less than 0.05). There was a strong correlation between Cl and Hl during dopamine fusion.

Cardiac Output↗
PubMed1981

Increase in hepatic blood flow and cardiac output during dopamine infusion in man.

The object of this paper was to evaluate the effect of a continuous dopamine infusion (10--12 micrograms/kg . min) on the estimated hepatic blood flow (EHBF) and cardiac output (CO) in man. Measurements were made in 3 periods: the initial control state, during dopamine infusion, and after the infusion. The CO (by thermodilution) and EHBF (by hepatic vein sampling after continuous indocyanine green (ICG) infusion) were measured during each phase. Ten subjects, with inapparent hepatic disease, hemorrhage, or hemodynamic anomalies, were studied. The results showed a 64% increase in the EHBF and a 49% increase in the CO. All subjects showed a return to the original baseline state after infusion. The EHBF/CO was 14% in the control period, 17.3% during infusion, and 13.4% after dopamine infusion. These changes were not statistically significant. Dopamine, therefore, increased both EHBF and CO, but the existence of intrahepatic dopaminergic receptors could not be established.

Cardiac Output↗