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C Dosne Pasqualini

Publications and source records attributed to C Dosne Pasqualini.

At least 19 recordsLinked to original sources
PubMed1991

Estrogen inhibition of MPA-induced mouse mammary tumor transplants.

Estrogen compounds were used to treat mice bearing syngeneic transplants of medroxyprogesterone acetate(MPA)-induced BALB/c mammary adenocarcinomas. Both MPA-dependent and MPA-independent tumor lines were used. These lines expressed estrogen (ER) and progesterone receptors (PR). We demonstrate that different doses of estradiol benzoate (EB) and 17-beta-estradiol (E2) inhibit tumor growth and induce tumor regression in both MPA-independent and -dependent tumors, even in the presence of MPA or progesterone (P). EB was unable to induce regression of (ER-) hormone-independent tumor lines. A few MPA-dependent tumors became resistant to the estrogenic treatment; in subsequent passages some of these tumors retained their MPA-responsiveness, although estrogen sensitivity was not recovered.

Adenocarcinoma↗
PubMed1990

Hormone dependence of a mouse mammary tumor line induced in vivo by medroxyprogesterone acetate.

The administration of MPA to virgin female BALB/c mice led to the development of mammary adenocarcinomas, which in further in vivo transplants gave rise to both MPA-dependent and MPA-independent lines. In this paper we chose one of the MPA-dependent lines with high contents of estrogen (ER) and progesterone (PR) receptors, and were able to demonstrate that a) the growth of these tumors could be manipulated by the administration or the withdrawal of the hormonal supply; b) PR were down-regulated in MPA-treated mice; c) progesterone had the same stimulatory effect as MPA on tumor growth; d) tumors did not grow in estrogen-treated mice; e) tumor growth was much lower in males than in females; f) the presence of the ovaries had a positive influence on tumor growth, even in the presence of MPA; g) the withdrawal of progestin pellets in ovariectomized mice usually led to complete remissions followed by regrowth of the tumors after several weeks; and h) the regrowing tumors maintained their steroid receptor pattern and (in 3 out of 4 cases) their hormone-dependent behavior in further passages.

Adenocarcinoma↗
PubMed1983

[Lack of relationship between viral leukemogenesis and immunosuppression in the mouse].

The relationship between immunodepression and leukemogenesis induced by a murine retro-virus. PLLV-T2, was studied in different strains of mice. Cellular immunity, using as parameters both allograft rejection and graft versus host reaction, was not affected during the early phase of leukemia development. As for humoral immunity, determined by the response to xenogeneic red blood cells and to lipopolysaccharides, no direct relationship between the immunodepression caused by the retrovirus and leukemogenesis could be encountered: in certain strains, such as DBA/2, with susceptibility to leukemogenesis similar to that of BALB/c, no decrease in the immune response was registered during the early phase of the disease. The results obtained demonstrate that immunodepression is not a necessary condition for the clinical appearance of this viral-induced leukemia indicating that humoral and/or cellular immunity would not play an important role as surveillance mechanism against this neoplasia.

Animals↗