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Biomedical subjects

C Dumitrache

Publications and source records attributed to C Dumitrache.

18 recordsLinked to original sources
PubMed1993

Alternatives in human reproduction. Methods, indications, prognosis, bioethical problems.

The alternative methods in human reproduction do nothing else than try to help an individual or a couple to achieve the primordial goal of life: perpetuation of the species. These methods try to reconstruct the biologic premises necessary for perpetuation by various means such as: a. in vitro fecundation correlated or not with artificial fecundation with donor, ovocyte donation, embryo donation, borrowed mother; b. intratubular transfer of gametes; c. unnatural circumstances, i.e., the possibility that men be a host for the embryo up to term, a hypothesis which for the time being is possible only in science-fiction. The birth of Louisa Brown in 1978 was the border between hope and certainty, between dream and pragmatism. Thus, the alternative methods of reproduction have become routine in the medical life and penetrated into the conscience of an ever greater number of people but at the same time have raised an immense number of questions regarding the status of the embryo and the foetus, but more important, of the child born under these circumstances. These questions await answers both from medicine and the law and have to be within the limits of the common sense. Those who participate in the in vitro fecundation programs should not lose their quality of being human, should pay respect to the nature and the natural, encourage hope and be moral.

Beginning of Human Life↗
PubMed1992

Therapeutic methods in endocrinology. General considerations.

The integrative character of the endocrine system and its regulation ways generate and motivate the specificity of endocrine therapy. The latter tries, by its methods and means, to restore hormonal homeostasis, to imitate the biologic rhythms of secretion, to respond to the stress needs, in fact it ensures the dynamics of the normal integration of an individual in the daily life with all its changes. This requirement is ensured by the methods of stimulation and suppression, hormonal substitution or depression of hormone bio-synthesis, blockade of enzymatic activation or desensitivation of the receptors to the hormonal message, etc. The association of the therapeutic means and methods has the purpose of bringing relief and the expectancy of a decent, controlled survival in inevitable iatrogeny. Endocrine therapy also ensures a normal growth and development, an acceptable IQ, a reasonable degree of sexualization, responds to the most important demand of life: perpetuation of the species. The range of endocrine therapy is perhaps the widest in medicine, starting with the disease and ending with the esthetic aspects of the individual. A good knowledge of the methods, means and especially their dynamics and specificity gives the endocrinologist the pragmatic outlook measured only by its efficiency.

Combined Modality Therapy↗
PubMedDate not supplied

[Turner's syndrome, diagnosis and therapeutical approach].

Turner's Syndrome is a rare chromosomal disorder of females (1 : 2500) characterized by short stature and the lack of sexual development at puberty. Other physical features may include a webbed neck, heart defects, kidney abnormalities, and/or various other malformations. Diagnosis should be considered in individuals with primary or secondary amenorrhea and adult women with unexplained infertility, particularly when such individuals also are short in stature. In childhood, growth hormone therapy is standard to prevent short stature as an adult. Estrogen replacement therapy usually is required, but starting too early can compromise adult height. The most frequent, the possibility of a good diagnosis appears at puberty. The early diagnosis needs the karyotyping as screening method. The correct treatment, which is made on time, has a good mental and social life influence.

Adolescent↗
PubMedDate not supplied

Dermatoglyphics in the virilizing polycystic ovary syndrome.

Quantitative and qualitative characteristics (form and orientation of the digital patterns, total digital ridges count, delta index, form and regional distribution of palmar patterns, palmar flexion creases, palmar delta index, atd angle, the direction of the A, B, C, and D palmar lines and the number of crests between the a, b, c, and d triradii) of digito-palmar dermatoglyphics in 33 women with virilizing polycystic ovary (VPO) were studied. The selection was made on the basis of the clinical examination and a complex bio-hormonal exploration of female patients with pilar virilism hospitalized in or treated at the outpatient clinic of the "C. I Parhon" Institute of Endocrinology between 1975 and 1984. The control lot was made up of 100 females and 100 males, clinically healthy, originally from various rural and urban areas in Romania. It was found that the VPO women come within the range of variability of the normal, with some dermatoglyphic peculiarities characteristic of the VPO syndrome; i.e., a lower total digital ridges count, and fewer ridges between the triradii at the basis of the fingers. Qualitatively, there is a preponderance of the loop-like digital patterns, especially those with radial orientation and palmar, compared to the normal, the VPO women present more frequently patterns in the interdigital space II. Palmar flexion lines indicate in VPO women a higher incidence of palmar transversal sulcus variants as compared to normal women. The existence of similar dermatoglyphic peculiarities both in VPO and in adrenogenital syndrome supports the hypothesis that the ovarian hormonogenesis disorders in the VPO syndrome may be genetically determined through an enzymatic defect.

Adult↗
PubMedDate not supplied

Transsexualism; new observations.

Ten cases of transsexualism have been studied. All the patients present gonadal lesions, modifications of the morphotype and small hormonologic anomalies. It is supposed that the gonadal lesions are frequently associated with this psycho-behavioural disorder. Thus transsexualism may be considered a trouble of the whole process of post gonadal sexualization.

Adult↗