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Biomedical subjects

C E Cann

Publications and source records attributed to C E Cann.

85 records · Page 5Linked to original sources

Precise measurement of vertebral mineral content using computed tomography.

A precise method of measuring vertebral mineral content by computed tomography has been developed. Calibration phantoms scanned with patients are used to provide corrections for machine drifts. Advanced software manipulation of the display images is used to reposition precisely to the midportion of each vertebral body. A long-term precision of 2.8% for mineral content has been obtained in excised vertebrae in a phantom simulating the human torso.

Bone and Bones↗

Comparison of vertebral and peripheral mineral losses in disuse osteoporosis in monkeys.

Vertebral mineral loss (measured by computed tomography) was compared to peripheral mineral loss (measured by photon absorptiometry) in immobilized monkeys. Significantly greater loss was found in axial cancallous bone than in peripheral cortical bone. The accuracy of vertebral CT measurements in one animal was determined using direct chemical analysis of excised vertebrae. Results indicate that mineral changes may be detected earlier in the vertebrae by CT than in peripheral bone using photon absorptiometric techniques.

Absorption↗

Possible parathyroid imaging using Ga-67 and other aluminum analogs.

Aluminum has been found to localize in parathyroid adenomas, but it has no isotopes suitable for imaging. Chemical analogs of aluminum were therefore evaluated as potential parathyroid seekers. Uptakes of gallium-67, scandium-46 and lutetium-177 were measured in rat parathyroid, thyroid, cervical muscle, and whole blood, over the time period 30 min to 8 days. Both differential and absolute uptakes of Ga-67 and Sc-46 in the parathyroids are greater than that reported for Se-75 selenomethionine. Uptake of Ga-67 is about 2% of the injected dose per gram of parathyroid tissue at 3-4 days, with a parathyroid-to-thyroid uptake ratio of about 6. Studies indicate possible imaging of adenomas at least as small as those now detected only with invasive methods.

Animals↗

Aluminum uptake by the parathyroid glands.

Aluminum-containing drugs are used extensively to bind dietary phosphate and as antacids, but little is known about toxicity and tissue uptake of ingested aluminum. Aluminum concentrations were measured by neutron activation analysis in tissues taken from hyperparathyroid and normal human subjects and from rats. The parathyroid glands contained significantly more aluminum per unit mass than did thyroid or cervical muscle. The concentration of aluminum in the parathyroids appears to be linearly related to dietary aluminum intake.

Aluminum↗

Noninvasive quantitation of liver iron in dogs with hemochromatosis using dual-energy CT scanning.

The concentration of iron deposited in the livers of two dogs with experimentally induced iron overload was determined by use of dual energy computerized tomographic (CT) scanning. A phantom was constructed, containing known amounts of iron-dextran solutions. CT scans of the phantoms, at 80 and 120 kVp, corrected for the response of water, showed a linear relationship between known iron concentrations and difference in CT number at the two scanning energies, with a change of 24 H units per 1000 mg% iron. Using the graph of this linear relationship, the amount of iron in dog liver was predicted, compared with the amount of iron measured from biopsy specimens, and analyzed by neutron activation analysis. A close correlation existed between predicted liver iron and measured iron concentration (r = 0.99). Dual-energy CT scanning appears to provide an accurate, noninvasive method of quantitating liver iron.

Animals↗

CT-determined pulmonary artery diameters in predicting pulmonary hypertension.

This study was to determine if the diameters of pulmonary arteries measured from computed tomographic (CT) scans could be used 1) as indicators of pulmonary artery hypertension and 2) as a reliable base for calculating mean pulmonary artery pressure. The diameters of the main, left, proximal right, distal right, interlobar, and left descending pulmonary arteries were measured from CT scans in 32 patients with cardiopulmonary disease and in 26 age- and sex-matched control subjects. Diameters were measured using a special computer program that could display a CT density profile of the artery and its adjacent tissues. The upper limit of normal diameter for the main pulmonary artery was found to be 28.6 mm (mean + 2 SD). In the patient group, the diameters were correlated with data from cardiac catheterization. In these patients, a diameter of the main pulmonary artery above 28.6 mm readily predicted the presence of pulmonary hypertension. The calculated cross-sectional areas of the main and interlobar pulmonary arteries (normalized for body surface area [BAS]) were found to give the best estimates of mean pulmonary artery pressure (r = 0.89, P less than 0.001 and r = 0.66, P less than 0.001). Multiple regression analysis gave the useful equation: mean pulmonary artery pressure = -10.92 + 0.07646 X area of main pulmonary artery/BSA + 0.08084 X area of the right interlobar pulmonary artery/BSA (r = 0.93, P less than 0.0001). Because CT allows precise, noninvasive measurement of the diameter of pulmonary arteries, it can be of value in detecting pulmonary hypertension and estimating mean pulmonary artery pressure.

Adolescent↗

CT of a bronchial phantom. Factors affecting appearance and size measurements.

In order to determine the most appropriate window settings for viewing CT of the bronchial tree, we performed CT of a bronchial phantom consisting of air-filled tubes measuring from 3.1 to 12.7 mm, oriented at varying angles relative to the scan plane, surrounded by water or air, and with scan collimation of 10 mm, 5 mm, and 1.5 mm. Using a computer program to graphically display CT number relative to the distance across the tube's lumen, it was found that a window mean of -150 H accurately estimated the internal diameter of tubes surrounded by water, at all angles, when collimation was 5 mm or 1.5 mm. With 10-mm collimation, tube diameter was slightly underestimated for tubes 9.5 mm or less when oriented 30 degrees or more from perpendicular to the plane of scan. At lower window settings and window widths of 500 H or less, all tube's diameters were significantly underestimated. At -150 H, with tubes parallel to and centered in the scan plane, 5-mm and 1.5-mm collimation were most accurate; with decentering of 4 mm, 10-mm collimation better showed the tube's lumen. When surrounded by air, tube wall thickness was best estimated using a window mean of -450 H.

Bronchi↗

Relative uptake of low- and high-osmolality contrast media in CT of brain tumors.

The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30 and 45 minutes was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.

Animals↗

Quantitative computed tomography for spinal mineral assessment: current status.

Quantitative CT (QCT) is an established method for the noninvasive assessment of bone mineral content in the vertebral spongiosum and other anatomic locations. The potential strengths of QCT relative to dual photon absorptiometry (DPA) are its capability for precise three-dimensional anatomic localization providing a direct density measurement and its capability for spatial separation of highly responsive cancellous bone from less responsive cortical bone. The extraction of this quantitative information from the CT image, however, requires sophisticated calibration and positioning techniques and careful technical monitoring.

Adult↗

A prototype high-purity germanium detector system with fast photon-counting circuitry for medical imaging.

A data-acquisition system designed for x-ray medical imaging utilizes a segmented high-purity germanium (HPGe) detector array with 2-mm wide and 6-mm thick elements. The detectors are contained within a liquid-nitrogen cryostat designed to minimize heat losses. The 50-ns pulse-shaping time of the preamplifier electronics is selected as the shortest time constant compatible with the 50-ns charge collection time of the detector. This provides the detection system with the fastest count-rate capabilities and immunity from microphonics, with moderate energy resolution performance. A theoretical analysis of the preamplifier electronics shows that its noise performance is limited primarily by its input capacitance, and is independent of detector leakage current up to approximately 100 nA. The system experimentally demonstrates count rates exceeding 1 million counts per second per element with an energy resolution of 7 keV for the 60-keV gamma ray photon from 241Am. The results demonstrate the performance of a data acquisition system utilizing HPGe detector systems which would be suitable for dual-energy imaging as well as systems offering simultaneous x-ray transmission and radionuclide emission imaging.

Americium↗

Relative uptake of low- and high-osmolality contrast media in CT of brain tumors.

The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30, and 45 min was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.

Animals↗

Comparison of xenon-enhanced CT with ultrafast CT for measurement of regional cerebral blood flow.

PURPOSE: To compare an ultrafast CT method for estimating regional cerebral blood flow with a more commonly used xenon-enhanced CT method. METHODS: Xenon CT and ultrafast CT were used to estimate regional cerebral blood flow (rCBF) in 12 healthy beagle dogs. Measurements were obtained for left and right hemisphere, cortical gray matter, basal ganglia, and deep white matter. The ability of each method to show differences in blood flow between regions of high flow (gray matter) and low flow (white matter) was evaluated, both for large (> 0.75 cm3) and small (< 0.5 cm3) regions of interest. In addition, side-to-side differences in rCBF were evaluated to determine the minimum difference that would suggest a significant alteration in blood flow. RESULTS: There was less interanimal variance in absolute rCBF measurements obtained using xenon CT; ultrafast CT appeared to accentuate rCBF differences between high flow and low flow regions. There were strong side-to-side correlations in rCBF when measured by ultrafast CT, which suggests that this technique may be particularly useful in detecting focal alterations in rCBF restricted to one hemisphere of the brain. CONCLUSIONS: Ultrafast CT measures of rCBF compare favorably with those obtained using xenon CT.

Animals↗