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Biomedical subjects

C E Drake

Publications and source records attributed to C E Drake.

9 recordsLinked to original sources
PubMed1985

Evaluation of the association of mitral valve prolapse in patients with Wolff-Parkinson-White type ECG and its relationship to the ventricular activation pattern.

The association of mitral valve prolapse (MVP) and Wolff-Parkinson-White (WPW) syndrome was examined using simultaneous two-dimensional and M-mode echocardiography. Twelve-lead electrocardiograms (ECGs) and two-dimensional echocardiograms (2DEs) were recorded in 24 patients with WPW. The location of the accessory pathway was predicted from the ECG as being in one of 10 possible sites correlating the delta wave polarity with epicardial mapping. Nineteen of the 24 patients had conduction via the accessory pathway and five were conducting normally during the recording of the echocardiogram. Mitral valve prolapse was found in 13 of 19 patients conducting via the accessory pathway. The only WPW patient with mitral valve prolapse during normal conduction had a chest deformity which has an independent association with mitral prolapse. No association was found between the prediction of the accessory pathway and the presence of mitral prolapse. We concluded that consideration should be given to the possibility that some patients demonstrating MVP do so as the result of the altered sequence of ventricular activation, rather than as the result of a structural abnormality.

Adult↗
PubMed1982

Cardiac drug overdose.

Toxicity from cardiac drugs is a particular management challenge since the manifestations of an acute overdose and the initial indications for the drug are often similar. Plasma drug levels are essential but must be interpreted in light of the clinical picture. Hypotension, due to either vasodilatation or decreased myocardial contractility, and arrhythmias are the principal cardiac manifestations, but noncardiac effects are sometimes more troublesome. An antiarrhythmic agent of the same class should not be used in treating an arrhythmia resulting from an overdose.

Arrhythmias, Cardiac↗
PubMed1980

ECG changes in hypothermia from sepsis and unrelated to exposure.

The patient had classic ECG changes of hypothermia (sinus bradycardia, prolonged PR interval, prolonged QT interval, and Osborn waves). These changes occurred in hypothermia resulting from sepsis, without exposure being a factor. Documentation of Osborn waves in this clinical setting supports the theory that they result as a direct consequence of myocardial cooling.

Bradycardia↗