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Biomedical subjects

C E Furneaux

Publications and source records attributed to C E Furneaux.

6 recordsLinked to original sources
PubMed1998

Craniofacial resection of anterior skull base tumours: factors contributing to success.

BACKGROUND: A case series of 20 consecutive patients followed for a minimum of 54 months following craniofacial resection of anterior skull base tumours is presented, with the aim of identifying complications and factors influencing survival. METHODS: A retrospective review of a case series of 20 consecutive patients was carried out. RESULTS: Dural invasion was significantly correlated with poorer survival. There was also a tendency for tumour grade and positive resection margins to be associated with poorer outcome. Most local recurrences occurred within 6 months of surgery, with the exception of adenocarcinoma of the ethmoids, in which recurrence occurred up to 36 months postoperatively. A variety of complications were encountered, with a marked decrease in serious complications from midway through the series. CONCLUSIONS: The change in pattern of complications may be indicative of a learning curve, or the discontinuation of the use of lumbar drainage.

Adenocarcinoma↗
PubMed1993

Racial differences between Maori and European New Zealanders in aneurysmal subarachnoid haemorrhage.

Racial differences in the incidence and rate of rupture of intracranial aneurysms are well recognized. A retrospective study of racial differences between Maori and European New Zealanders presenting to the Auckland Regional Neurosurgical Unit between 1985 and 1990 was conducted. It was found that the incidence per 100,000 of the population for all aneurysms was 14.3 for Europeans and 25.7 for Maoris. The mean age at rupture was 10 years earlier in Maoris with single aneurysms. A strong association between aneurysmal subarachnoid haemorrhage and cigarette smoking was found in both groups not only for single, but also for multiple aneurysms. Maoris were also found to have an abnormally high incidence of middle cerebral artery aneurysms and a low incidence of vertebrobasilar ones compared with Europeans.

Adult↗
PubMed1993

In vitro study of the effect of photodynamic therapy on pituitary adenomas.

Photodynamic therapy (PDT) has been employed in the management of recurrent cerebral gliomas, but its activity against pituitary adenomas has not been specifically studied. An in vitro study of the effects of PDT against a variety of pituitary adenomas was conducted. It was found that PDT using haematoporphyrin derivative as a photosensitizer showed dose dependent activity against a variety of pituitary adenomas. The activity of PDT against pituitary adenomas should be investigated further and may hopefully provide a useful form of adjuvant therapy for preventing recurrence of micro-invasive pituitary adenomas or dealing with established recurrence after surgery and radiotherapy.

Adenoma↗