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C E Hedinger

Publications and source records attributed to C E Hedinger.

23 records · Page 2Linked to original sources
PubMed1982

Immune complex orchitis in infertile men. Immunoelectron microscopy of abnormal basement membrane structures.

Testicular biopsies from 30 patients with fertility disorders were investigated by peroxidase-labeled antibodies against IgG and C3 at an ultrastructural level. Three types of abnormal basement membrane structures (ABMS) proved to be positive. Immune-type deposits (ABMS type 2), ABMS with vesicular particles (ABMS type 4), and those with membranous structures (ABMS type 5) stained positively for IgG and C3. In 21 cases ABMS were positive for at least one of the antisera. Two additional cases showed a linear reaction for IgG and C3 in the basement membrane. According to the number and size of positive ABMS, the cases were divided into three groups. Group I contained 10 cases with extensive ABMS types 2, 4, and 5 positive for IgG and C3 and two cases with linear positivity. At light microscopy, the changes varied from light to severe tubular atrophy. In these latter cases ABMS types 4 and 5 predominated, whereas in the light and focal tubular lesions ABMS type 2 did. In group II, eight cases revealed few and small ABMS positive by immunoelectron microscopy and no more than slight tubular changes at light microscopy. In group III, minimal or no ABMS were present, but in three cases mast cells were numerous in the interstitial tissue. The demonstration of immune deposits in the basement membrane of seminiferous tubules is interpreted to be the result of an antibody-mediated damage to the germinal epithelium leading to tubular atrophy. In one case obstruction of the sperm ducts and in another torsion of the testis are incriminated as events triggering the autoimmune process. Linear staining of the basement membrane for IgG and C3 in two cases suggests the development of antibasement membrane orchitis.

Adult↗
PubMed1982

Abnormal basement membrane structures of seminiferous tubules in infertile men.

Testicular biopsies from 60 patients with impaired fertility were investigated by electron microscopy for changes in the basement membrane of seminiferous tubules. Six different types of abnormal basement membrane structures (ABMS)--analogous to those of glomerular basement membrane disease--have been found to a variable extent in biopsies of 33 cases. The occurrence of ABMS correlated with the severity of tubular changes, and ABMS were absent in tubuli seminiferi with an intact germinal epithelium. Except for ABMS type 2, thought to represent immune complex deposits, the origin of ABMS is unknown. ABMS type 2 was present in 21 cases. Since similar deposits have been observed in rabbits developing immune complex orchitis after vasectomy, our findings indicate the occurrence of immune complex orchitis in infertile men.

Adult↗
PubMed1980

Extratesticular gonadal stomal tumor in the pelvis. A case report with immunoperoxidase findings.

A 40-year-old man with two normally descended testicles and no signs of hormonal anomalies developed a fist-sized extraperitoneal tumor to the left of the urinary bladder. Histologic diagnosis was that of a probably malignant gonadal stromal tumor because of considerable mitotic activity and widespread vascular invasion. Retroperitoneal lymphadenectomy showed no metastatic disease, and the patient is well two years after surgery. By use of an immunoperoxidase method we could demonstrate estradiol and testosterone in the tumor cells. The findings in this case are unique in regard to the extratesticular location of the tumor and support the current view that gonadal stromal tumors arise from a primitive cell with a multidirectional potential for differentiation.

Adult↗