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Biomedical subjects

C E Henneman

Publications and source records attributed to C E Henneman.

7 recordsLinked to original sources
PubMed1992

Continuous quality improvement of Pap smears in an ambulatory care facility.

This article describes how the H. Claude Hudson Comprehensive Health Center (Los Angeles) implemented a continuous quality improvement program to reduce the unacceptably high rate of nonrepresentative Papanicolaou (Pap) smears (those lacking endocervical component). A review of the literature and telephone surveys indicated that the optimal Pap smear technique includes the use of a cervical cytobrush. Several cytobrushes were evaluated and one was chosen to be used facilitywide. Clinicians were given in-services on the proper cervical sampling techniques using the cytobrush. The rate of nonrepresentative Pap smears decreased approximately 12% during a five-month period; this has been attributed to uniform implementation of the cytobrush technique in nonpregnant patients, in-service education, and cooperative teamwork.

Clinical Laboratory Techniques↗
PubMed1984

Efficacy of hepatitis B immune globulin in prevention of perinatal transmission of the hepatitis B virus.

An efficacy trial of hepatitis B immune globulin in the prevention of perinatal transmission of hepatitis B virus infection was conducted in Los Angeles. Ten infants born to hepatitis B surface antigen (HBsAg)-and hepatitis B e antigen (HBeAg)-positive carrier mothers as well as 4 infants born to mothers with acute hepatitis B in the third trimester of pregnancy received hepatitis B immune globulin without randomization. Twenty infants born to HBsAg- and antibody to hepatitis B e antigen (anti-HBe)-positive carrier mothers were randomized to receive hepatitis B immune globulin or a placebo. All infants were followed for up to 18 mo. Four infants (2 born to HBeAg carrier mothers, 1 to an anti-HBe carrier, and 1 to a mother with acute hepatitis) became HBsAg-positive carriers, whereas another infant, whose mother was an HBeAg carrier, developed a transient anicteric hepatitis B infection. All infants who became infected did so after 9 mo of age as hepatitis B immune globulin protection waned. In infants born to HBsAg-positive carrier mothers, active immunoprophylaxis with the hepatitis B vaccine must be used in conjunction with hepatitis B immune globulin.

Acute Disease↗
PubMed1983

Colloid osmotic pressure: variations in normal pregnancy.

Pregnancy is associated with an increase in the extravascular fluid by about two litres. The regulation of fluid flux across capillary membrane is dependent on the STARLING's forces. Thus increased fluid shift into the extravascular space may occur during pregnancy when the intra-capillary hydrostatic pressure exceeds the opposing influence of plasma colloid oncotic pressure (COP). In order to evaluate these forces more fully, COP, hematocrit (HCT), serum total solids (STS), mean blood pressure (MBP) and MBP-COP gradient (M-C) were measured cross-sectionally in 184 women with normal uncomplicated pregnancy. COP fell gradually during the first and second trimesters, lowest at 30-34 weeks, thereafter it rose. The relationship of COP and gestational age was best described by the quadratic equation. The patterns of changes of HCT and STS with respect to gestational age were similar to COP. MBP and M-C were linearly correlated to gestational age. The increment in M-C with advancing gestational age would promote fluid flux from intra to extravascular space in normal pregnancy.

Blood Pressure↗
PubMed1979

Failure of immune serum globulin to prevent hepatitis B virus infection in infants born to HBsAg-positive mothers.

Twelve infants, born to mothers with hepatitis B virus infection, were inoculated within 7 days of birth with immune serum globulin containing antibody to hepatitis B surface antigen (HBsAg) titers of 1:32 to 1:64 as measured by passive hemagglutination. Six of nine infants (66.7%) born to HBsAg-positive carrier mothers became HBsAg-positive within 3 mo of age. In addition, two of three treated infants born to mothers with acute hepatitis B during the delivery period also developed HBsAg. The hepatitis e antigen was detected in four of five carrier mothers and in two mothers with acute hepatitis, whose infants subsequently became HBsAg positive. In addition, hepatitis B-specific DNA polymerase activity was detected in the seven HBsAg-positive mothers who transmitted the virus to their infants. All eight infants have remained persistently HBsAg positive. Thus, the immune serum globulin containing low-titer antibody to HBsAg is not protective when given to infants born to HBsAg carrier mothers or to mothers with acute hepatitis B during the delivery period.

Carrier State↗