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Biomedical subjects

C E Hotte

Publications and source records attributed to C E Hotte.

7 recordsLinked to original sources
PubMed1981

Comparative extraocular muscle blood flow.

This study was designed to quantitatively determined blood flow to the extraocular muscles (EOM) of animals showing a wide range of ocular motility Blood-flow values (ml/minute/gm) for EOM in primates (0.25 +/- 0.03), dogs (0.33 +/- 0.06), sheep (0.12 +/- 0.01), and geese (0.12 +/- 0.04) were determined using the Reference Sample Method with 15 +/- 3 micrometer 103Ru microspheres and complete cardiovascular monitoring. Mammalian EOM blood flow was significantly higher than that determined for other skeletal muscle; however, EOM blood-flow values for sheep were significantly lower than those for primates and dogs. No significant blood-flow differences were found between avian EOM and other skeletal muscle, reflecting the unique avian ocular anatomy. These data indicate that high blood flow is not a general property of EOM and suggest a relationship between functional ocular motility and blood flow.

Animals↗
PubMed1980

The effect of complete tenotomy on blood flow to the anterior segment of the canine eye.

The relative importance of the anterior ciliary arteries to blood flow to the anterior segment and the quadrant distribution of blood to the iris, ciliary body, and ciliary processes were determined in canines with the use of 15 +/- 3 mum 103Ru microspheres with the reference blood flow method. Recti muscles were isolated in both eyes. Then with one eye serving as a sham-operated control, anterior ciliary artery blood flow was disrupted by recti tenotomy immediately prior to microsphere injection. Tenotomy resulted in a significant decrease in blood flow to the anterior segment (0.14 +/- 0.03 ml/min/gm vs. 0.26 +/- 0.05 in the untenotomized control) and to the unit iris, ciliary body and ciliary processes (I, CB, CP) (0.92 +/- 0.16 ml/min/gm vs. 1.44 +/- 0.22 in the untenotomized control). Blood flow values for the anterior segment and the unit I, CB, CP in the tenotomized eye were 50% to 60% of those of the control eyes, indicating that the majority of blood flow to the canine anterior segment is not disrupted by complete tenotomy. In the control eye, blood flow values for the medial quadrant of the unit I, CB, CP were significantly higher (p < 0.05) than those of the inferior or superior quadrants. Blood flow values for all quadrants in tenotomized eyes were 55% to 70% of those for control eyes. Therefore the anterior ciliary arteries do not contribute the majority of blood flow to the canine anterior segment.

Animals↗
PubMed1979

The in vitro stability of [131I]o-iodohippurate.

The kinetics of [131I]o-iodohippurate (OIH) decomposition were evaluated to develop an accelerated technique for the prediction of radiopharmaceutical stability. Decomposition due to temperature and self-absorbed radiation was characterized simultaneously. Using the proposed technique, the extent of OIH decomposition was calculated a priori to be 7.6% over a 28-day period when extrapolated to a specific concentration of 2 mCi/ml and a storage of 25 degrees C. Extended storage under these same conditions yielded a mean decomposition value of 8.0% over an equivalent time interval. The techniques developed offer a rapid means of accurately assessing the stability of new radiopharmaceuticals as they are developed.

Drug Stability↗
PubMed1975

Generator-produced 99m TcO4-: carrier free.

A solution of 99m-TCO4-minus, as eluted from a 99Mo-99mTc radionuclide generator contains a greater chemical quantity of technetium than that attributable to the metastable isomer alone. The isomeric transition of the radionuclide of interest, 99mTc, gives rise to a determinable and chemically significant quantity of technetium carrier, 99Tc. A method is presented for calculating the total chemical quantity of technetium in a generator eluate.

Molybdenum↗