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Biomedical subjects

C E McCoy

Publications and source records attributed to C E McCoy.

26 records · Page 2Linked to original sources
PubMed1985

Reduction of postoperative pain parameters by presurgical relaxation instructions for spinal pain patients.

This study investigated the effects of a relaxation instruction session conducted presurgically with postsurgical pain parameters for patients undergoing spinal surgery. Results indicated that the relaxation group (n = 50) as compared with an equivalent group (n = 50) matched to type of surgery and sex type, workers compensation status had significant reduction of days of hospitalization, complaints noted by nurses, and medications (primarily demerol and phenaphen). Sex type, age, and workers compensation status were not significant factors regarding these outcome measures. The results were considered in light of the anxiety/pain explanation of pain sensitivities with implications for health care with spinal pain surgical candidates.

Adult↗
PubMed1983

The relationship of Minnesota Multiphasic Personality Inventory (MMPI) profile clusters to pain behaviors.

Previous research involving cluster analysis of Minnesota Multiphasic Personality Inventory (MMPI) profiles among persons with chronic low back pain has suggested the existence of four distinct profile clusters. The present study had two goals: (1) to replicate the previous finding independently and (2) to investigate the relationship of the profiles to the subjects' self-reported pain history and response to treatment. Subjects were 92 patients in a multimodal inpatient low back-pain treatment program. A cluster analysis of the MMPI profiles was performed and the resultant clusters were compared in terms of histories and treatment outcome. The four clusters were successfully replicated for the total sample and for males and females separately. The profiles were significantly related to subjects' pain histories, but only one outcome difference was found. It was inferred that the MMPI is of value in understanding patients' pain coping behaviors but that further research is needed to explore the utility of the MMPI in understanding their response to treatment.

Back Pain↗
PubMed1983

Human ciliary body epithelium in culture.

Human ciliary body epithelial cells have been maintained in vitro and have been partially characterized by the determination of growth rate, morphology, and ultrastructural parameters. The dissection technique employed allows the separation of pure ciliary body epithelium with a predominance of cells being from the nonpigmented layer. Growth curves indicate this cell population follows a prolonged rate of growth compared to other primary cell cultures. Loss of pigment granules noted by light microscopy were documented by morphometric analysis of electron micrographs. Thirty-two percent of the cultures attempted were successful. Maintenance of these cells in vitro may provide a means for studying their enzyme systems, growth factors, reactions to various stimuli, and the effects of this cell population on other intraocular tissues.

Adolescent↗
PubMed1976

Morphologic and immunologic studies of a human colon tumor cell line (SW-48).

A permanent human tissue culture cell line (SW-48) has been established from an adenocarcinoma of the transverse colon. Cells in the center of early colonies were cuboidal and loosely bound; cells on the periphery of the same colonies were more columnar, the nuclei were displaced toward the basal region, and the free surface formed stunted microvilli. These columnar cells ofter aligned themselves to resemble normal absorptive tissue. Carcinoembryonic antigen (CEA) was identified by immunofluorescent microscopy on the surface membrane of the tumor cells. Significantly more CEA could be isolated from the culture medium than from the whole cells. On agar gel diffusion analysis with a monospecific anti-CEA serum (G.P. 32), SW-48 CEA and CEA preparations from solid tumors demonstrated complete identity.

Adenocarcinoma↗
PubMed1976

Classification of human colorectal adenocarcinoma cell lines.

Eleven human colorectal adenocarcinoma cell lines established in this laboratory were classified into three groups based on morphological features (light and electron microscopy), modal chromosome number, and ability to synthesize carcinoembryonic antigen (CEA). Group 1 cell lines contained both dedifferentiated and differentiating cells growing in tight clusters or islands of epithelium-like cells; their modal chromosome number was about 47, and they synthesized small to moderate amounts of CEA. Group 2 cell lines were more dedifferentiated, were hyperdiploid, and synthesized small amounts of CEA. Group 3 cell lines were morphologically similar to those of Group 1 by light microscopy. They differed ultrastructurally by containing microvesicular bodies; the modal chromosome number varied from hyperdiploid to hypertriploid or they had bimodal populations of hypodiploid and hypertriploid cells, and they synthesized relatively large amounts of CEA. No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA. These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.

Adenocarcinoma↗
PubMedDate not supplied

A motivational scoring system for outcome prediction with spinal pain rehabilitation patients.

The aim of this study is to demonstrate an effective method of testing using the Sixteen Personality Factor Questionnaire (16 PF) along with the Minnesota Multiphasic Personality Inventory (MMPI) to predict outcome criteria in a spinal pain clinic. Using an objective system of criteria for patient achievement, including goals attained, pain estimates, psychological adjustment, medication reduction, and physical function, a quantitative method of scoring was employed to find success and failure. Using appropriately constructed testing methods, a very high level of predictability of outcome is now available. The combined use of the 16 PF and the MMPI can be relied upon to predict effective results in a spinal pain program with considerable confidence.

Back Pain↗