PubMed Health⌕ Search

Biomedical subjects

C E Modly

Publications and source records attributed to C E Modly.

5 recordsLinked to original sources
PubMed1989

Evaluation of alopecia: a new algorithm.

The clinical evaluation of alopecia is becoming less precise as more histopathologic correlations become available. According to the classic approach, the clinician should initially differentiate between scarring and nonscarring alopecia. Because several case reports in the past ten years have demonstrated that the definition of "scarring alopecia" is ambiguous, the use of the traditional schema--scarring versus nonscarring--may well be outmoded. Therefore, we propose a new algorithm for the evaluation of alopecia that emphasizes the importance of both clinical and histologic findings.

Alopecia↗
PubMed1988

Tick-borne dermatologic diseases.

Inquiries regarding tick exposure can be important in dermatologic diagnosis and treatment since ticks can be vectors of a diversity of infectious diseases. The classic teaching is that ticks are best removed with nail polish, solvents, petrolatum, mineral oil, or a hot match. However, a recent evaluation of tick removal revealed that mechanical removal with forceps preceded and followed by disinfection is the most effective method. In most cases, should the characteristic dermatologic lesion or systemic symptoms appear, appropriate treatment should be initiated for presumptive diseases.

Animals↗
PubMed1987

Dermatologic manifestations of fluoride exposure.

The dermatologic manifestations of fluoride/fluorine exposure have not been established definitively. There is no evidence of allergic dermatologic reactions to fluorides, and the most reproducible toxic reactions are those to inorganic gaseous fluorines and solutions of hydrogen fluoride, which produce burns. Anecdotal associations have included papulondular and pustular eruptions secondary to topical fluoride-containing preparations, telangiectases and Chizzola maculae in the setting of airborne inorganic fluorides. Carefully controlled studies are needed to identify fluoride as the primary cause of these dermatoses, as well as to correlate the gross pathology, specific histopathology, and plasma levels of fluorine.

Drug Eruptions↗
PubMedDate not supplied

Capsaicin as an in vitro inhibitor of benzo(a)pyrene metabolism and its DNA binding in human and murine keratinocytes.

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the active principle of capsicum fruits, such as hot peppers, is a known inhibitor of substance P. This substance was also found to be a potent in vitro inhibitor of human and murine epidermal metabolism of benzo(a)pyrene (BP) and the enzyme-mediated binding of BP metabolites to DNA. In both untreated and 3-methylcholanthrene-treated neonatal rat epidermal microsomes, capsaicin resulted in a dose-dependent inhibition of aryl hydrocarbon hydroxylase activity with an I50 value of 3.0 X 10(-4)-3.6 X 10(-4) M. A Lineweaver-Burk plot of the inhibition of aryl hydrocarbon hydroxylase activity suggested that the inhibition is of the noncompetitive type with Ki value of 50 microM. Capsaicin also inhibited BP metabolism and the binding of 3H-BP to DNA in BALB/c mouse and human keratinocytes. The formation of BP-7,8-diol was also substantially diminished in both systems in the presence of capsaicin (180-300 microM). Our results indicate that the substance P inhibitor, capsaicin, is also an inhibitor of epidermal BP metabolism and DNA binding of its metabolites. Therefore, in addition to its neurological effects, capsaicin may represent a new category of compound with anti-carcinogenic effects.

Animals↗