Biomedical subjects

C E Stankard

Publications and source records attributed to C E Stankard.

3 recordsLinked to original sources

PubMed1993

Chronic pressure ulcer carcinomas.

Carcinomas arising from chronic pressure ulcers, Marjolin's ulcers, are an uncommon occurrence. They are virulent cancers that require aggressive surgical treatment. We present 3 such cancers including the first report of a squamous cell carcinoma arising in a distal extremity pressure ulcer. Carcinomas arising in chronic pressure ulcers behave more aggressively than other types of Marjolin's ulcers and, therefore, they need to be treated more aggressively. Extensive surgical excisions with wide surgical margins are necessary and elective lymph node dissections should be considered for optimal therapy.

Adult↗

PubMed1992

The treatment of isolated pancreatic metastases from renal cell carcinoma: a surgical review.

The pancreas is an uncommon site of metastasis for renal cell carcinoma. Multiple metastasis to the pancreas from a renal cell carcinoma 17 yr after the primary diagnosis is even more uncommon. Such a case, treated by total pancreatectomy, and a review of the relevant literature including all recorded cases of surgically treated pancreatic metastasis of renal cell carcinoma, are presented.

Carcinoma, Renal Cell↗

PubMed1991

The solution conformations of lidocaine analogues.

IR and 1H NMR studies in CDCl3 and CCl4 of a series of tertiary aminoxylidides with the amino group in the 2 to 6 position of the acyl chain are described. Lidocaine, diethylaminoaceto-2',6'-xylidide, forms an intramolecular five-membered ring hydrogen-bonded monomer at all concentrations in both solvents. beta-Diethyl-amino-propiono-2',6'-xylidide forms an intramolecular six-membered ring hydrogen-bonded monomer in CDCl3 and CCl4 but a trans intermolecularly associated species is the major form present at high concentrations in CCl4. The longer-chain homologues are mixtures of nonassociated trans and cis monomers at low concentrations but associated trans forms predominate at high concentrations. Evidence for the presence of a hydrogen-bonded seven-membered ring intramolecular monomer in CDCl3 for gamma-diethylaminobutyro-2',6'-xylidide is presented. The relationship between the molecular conformation and the partition coefficient is discussed.

Carbon Tetrachloride↗