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Biomedical subjects

C E Urbani

Publications and source records attributed to C E Urbani.

8 recordsLinked to original sources
PubMed1992

Epidemiological, clinical and allergological observations on pompholyx.

We have studied a group of 104 patients with pompholyx, to investigate the relationship between allergological factors and its etiopathogenesis. The following examinations were performed: blood sampling (routine tests and IgE levels), allergological tests (patch, prick, intradermal, and oral provovation tests with nickel sulphate), skin biopsy to exclude pemphigus vulgaris or bullous pemphigoid. An accurate history of familial and personal allergic diathesis was enquired for and various possible aggravating factors (season, microclimate, perspiration and emotional stress) were considered. The results were age and sex-matched with a healthy control group (208 subjects). We found familial and personal atopic diathesis in 50% of patients versus 11.5% of controls (p less than 0.001); 39 patients (37.49%) also had high levels of IgE. Nickel sulphate was the allergen with the highest positivity on patch testing: 20.19% versus 6.25% of the control group (p less than 0.001). The % of patients allergic to nickel reached 26%, including those (6 patients) reacting to the oral provocation test. Season (43 patients) and hyperhidrosis (38) were the aggravating factors most commonly claimed. We detected no correlation between age, sex, grading of pompholyx and the allergological parameters investigated. Though several different allergological findings have previously been reported in dyshidrosis, their role in its pathogenesis has not yet been fully explained. We think that different haptens or antigens can produce the same clinical and histological picture of pompholyx in predisposed subjects.

Adolescent↗
PubMed1990

Incidence of polycystic ovaries in patients with late-onset or persistent acne: hormonal reports.

Forty-six women affected by late-onset or persistent acne were studied in order to investigate the frequency of hormonal abnormalities and polycystic ovaries. Hirsutism, perioral distribution of acne lesions and irregular menses were recorded. Hormonal measurements and ovarian echographies were performed. Twenty-four patients were affected with polycystic ovaries, detected by ultrasound scanning. Among the acne patients, the women with ovarian abnormalities had higher values of androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate and luteinizing hormone (LH), and a higher LHT/follicle-stimulating hormone ratio than those with acne and without ovarian abnormalities. This study indicates the prevalence of polycystic ovaries in women with late-onset or persistent acne. Moreover, hormonal abnormalities indicate a subgroup of acne patients defined by the presence of ovarian disorders.

Acne Vulgaris↗
PubMed1990

[Oxatomide in the treatment of pruriginous skin diseases of various nature].

A study in two parts was carried out with the aim of developing a formulation of oxatomide for topical dermatological use. During the first part of the study the safety of 4 formulations (cream and gel at 2.5% and 5%) was evaluated by means of the patch-test, while in the second a clinical trial was carried out in order to assess the anti-itching efficacy of the formulation chosen on the basis of the results of the first part (gel 5%). During the double blind study of safety, only one patient out of 33 studied showed a reaction, and with all formulations. In the second part of the study 30 patients (16 F, 14 M) were admitted, aged between 13 and 77 years (mean age 48.2) and suffering from cutaneous diseases with itching. The study was open and each subject applied oxatomide gel at 5% twice a day for 14 days. There was a subsequent follow-up without therapy of 14 days. During the study a significant (p less than 0.01 between times) improvement in lesions was observed, with an average reduction of 61% for itching, 54% for erythema, 60% for excoriations and 59% for lichenification. Acceptability and safety were good. Only one subject suspended treatment due to the onset of burning on the site of application. In the follow-up period the therapeutic results achieved were generally maintained.

Adolescent↗
PubMed1989

[Skin diseases and primarily dermatologic cutaneous manifestations of venous disorders. Clinical elements and differential diagnosis].

The paper describes the most common dermatoses having a venous pathogenesis, with particular reference, because of their incidence, to the cutaneous manifestations of varicose syndrome. The pathophysiological basis, clinical picture and diagnostic investigations of dermatoses in venous diseases are discussed and compared with other cutaneous manifestations of non-venous diseases with which they are easily confused. The great importance of a specialised multidisciplinary approach for the correct management of a patient with these dermatological problems is emphasised.

Diagnosis, Differential↗