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Biomedical subjects

C Eşanu

Publications and source records attributed to C Eşanu.

At least 19 recordsLinked to original sources
PubMed1978

Biochemical changes in the rat brain associated with dinitrophenol-induced brain edema.

The present paper was designed to the study of cerebral edema induced by intracarotid infusion of dinitrophenol. The determinations included variations in three lysosomal enzymes (acid phosphatase, cathepsin C and beta-glucuronidase), Na+-K+-ATP-ase, changes in cerebral RNA and protein concentrations and the synthesis of these macromolecules in vitro. In experimental brain edema a drastic drop in the activity of lysosomal enzymes took place. The acid phosphatase decreased to less than 30% of controls. Cathepsin C and beta-glucuronidase were reduced about 30% and 50% of control levels respectively. Protein concentration in the cerebral tissue also decreased by more than 50%. The concentration of RNA, RNA synthesis, and the level of Na+-K+-ATP-ase remained unchanged. Protein synthesis was stimulated by 75% (against controls). All these phenomena were suppressed when the animals subjected to the action of dinitrophenol were concomitantly treated with the antiacidotic substance, tris (hydroxymethyl) aminomethane.

Acid Phosphatase↗
PubMedDate not supplied

Pituitary function in 20 cases of prolactinoma in females.

Women with prolactinic pituitary tumor in the fertile period have increased (60-400 ng/ml) blood prolactin values and decreased LH and FSH as compared to healthy women of the same age. Among the mechanisms implied in prolactin hypersecretion in females with prolactinic tumor worth noting are: low receptivity to dopamine, low dopamine production, elevated serotonin and TRH production, stress factors. Suppression of prolactin secretion with bromcriptine induces a rise in LRH and consequently in LH and FSH. A drug treatment is suggested for prolactin hypersecretion in women with prolactinic pituitary tumor, consisting in association of small doses of bromcriptine, L-DOPA, metergolina and thyroxine, and avoidance of stressing circumstances.

Adult↗
PubMedDate not supplied

Secretion of basal gonadotropins after LRH decapeptide and tripeptide. Stimulation in hypogonadotropic hypogonadism.

Sixteen females with pubertary delay of the isolated hypogonadotropic hypogonadism type (mean age 19 years, age range 14-25 years) were studied by radioimmunoassay of LH and FSH. The mean values +/- SE were compared to the values obtained from 10 girls in the B 5 Tanner stage and 15 normal adult women investigated on the 14th and 21st day of their ovarian cycle. Two females were given the LRH decapeptide and LRH-LA tripeptide stimulation test. In one case the daily variations of circulating serum LH and FSH were followed up. The fluctuations found suggest an ovarian rhythm which is present in the normal adult woman.

Adolescent↗
PubMedDate not supplied

Variations in LH and FSH serum gonadotropins in the hypophyseal chromophobe adenoma and acromegaly in the woman in relation to age.

Investigation of the gonadotropic function by radioimmunoassay of serum LH and FSH in 62 women with hypophyseal chromophobe adenoma and acromegaly in relation to age and by comparison with 40 normal women revealed low values for LH and FSH during the reporduction period (20--43 years) and increased values in the postmenopausal period (48--84 years) like in physiologic postmenopause. The increase of the gonadotropic function in the hypophyseal tumoral syndrome of the chromophobe adenoma and acromegaly type above the age of 48 from low values compared to the normal to high values like those in physiologic menopause (a gonadotropic turning phenomenon) demonstrate an alteration of the hypothalamic receptors in relation to age and to these diseases.

Acromegaly↗
PubMedDate not supplied

Plasmatic level of angiotensin I in normal subjects of various ages, in Cushing's syndrome and in normal and pathologic pregnancy.

Using RIA for determining the plasmatic renin activity in orthostatism according to the method of Fyhrquist we obtained in the control group of adult subjects nonsignificant variations in relation with sex and age, and in the group with Cushing's syndrome associated with arterial hypertension nonsignificantly increased values as against the controls. In pathologic pregnancy (toxemic pregnancy with arterial hypertension and edemas), the plasmatic renin (PR) activity was significantly higher ( less than 0.001) than in the group with physiologic pregnancy.

Adult↗
PubMedDate not supplied

Circulating FSH, LH, GH, testosterone, TSH, T3, T4, prolactin and insulin in boys during puberty.

The dynamics of the serum FSH, LH, GH, T, TSH, T3, T4, prolactin (PRL) and insulin levels was studied in 50 healthy boys aged between 8 and 18 years, in correlation with the development of the gonad (sexualization) assessed through the five-stage classification (G I-G V) proposed by Tanner. The results reveal the role of gonadotropins (especially LH) and testosterone in the growth and development of the child and especially in the sexualization process through a progressive increase from stage GI to GV. In stage GV, LH and T reach the values of an adult. GH shows a peak during the maximum height and weight increase. Thyroid hormones T3 and T4 also prove their role, showing higher values in the span of accelerated growth and significantly lower levels in the final stages of puberty (G IV-GV). The dynamics of prolactin secretion during the pubertal development shows (in all the 5 stages of sexualization) close serum levels. Serum insulin level also shows a progressive increase all along the pubertal years (from G I to G V).

Adolescent↗