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Biomedical subjects

C Elton

Publications and source records attributed to C Elton.

2 recordsLinked to original sources

Laparoscopic appendicectomy: a trainee's perspective.

Minimally invasive surgery is rapidly becoming an integral part of general surgery. Many general surgeons have been trained to undertake laparoscopic cholecystectomy. It has been recommended that laparoscopic appendicectomy should be the training operation for junior surgeons. The aim of our study was to assess whether laparoscopic appendicectomy training can safely be introduced to junior surgeons in a district general hospital. During the 11 month study period, 27 laparoscopic and 38 open appendicectomies were performed. The median anaesthetic time was 80 min for laparoscopic and 52.5 min for open appendicectomies. Laparoscopic appendicectomies cost, on average, 618 pounds and open appendicectomies 770 pounds per case. The complication rate between the two procedures was equal. We therefore showed that laparoscopic appendicectomy by junior surgeons is both safe and cost-effective. Although the registrar did most of the laparoscopic appendicectomies, with resultant less operating for the SHO, laparoscopic appendicectomy provided the SHO with training in diagnostic laparoscopy and laparoscopic dissection. We conclude that basic laparoscopic training should be introduced early in surgical training, after which laparoscopic appendicectomy is a safe procedure for surgical trainees.

Adolescent

Ethanol-induced growth inhibition in embryonic chick brain is associated with changes in cytoplasmic cyclic AMP-dependent protein kinase regulatory subunit.

Several lines of research have suggested that ethanol-induced changes in the adenylate cyclase/protein kinase cascade may contribute to the growth retardation observed in infants exposed to ethanol in utero. Based on studies with an embryonic chick model, the data presented here suggest that chronic ethanol treatment significantly lowered the binding of cyclic AMP by protein kinase regulatory subunit (RII) and reduced the level of phosphorylation of RII by the endogenous cytoplasmic protein kinase catalytic subunit. Furthermore, ethanol treatment altered the phosphorylation of at least one other brain cytosolic protein (molecular weight = 62-65 kD).

Animals