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Biomedical subjects

C Emde

Publications and source records attributed to C Emde.

43 records · Page 3Linked to original sources
PubMed1984

[Tolerance of intraduodenal tube feeding. Prospective studies of the tolerance of a 10-day, continuous intraduodenal administration of a peptide diet and its effects on various serum parameters in healthy subjects].

Filiform nasoduodenal nutrition tubes in connection with portable infusion pumps are now available and by this way continuous enteral nutrition is given to a certain number of patients, thus avoiding expensive parenteral nutrition which demands a great deal of nursing care and bears a greater risk of complications. In order to study the acceptance and effects of this nutrition, 10 healthy persons were fed by the new system with a fiber-free, low molecular peptide diet. The probands had to write a daily protocol and, at the end of the test, had to answer a questionnaire regarding the effectivity and social consequences of the system and their subjective sensations. Before and after the enteral nutrition phase, different serum parameters were also determined. The results show that a continuous intraduodenal nutrition by tube can be achieved outside the clinic allowing to exercise the profession. The general well-being of the probands was moderately disturbed only by the tube whereas the other points from the questionnaire were less disturbing. Regarding the serum parameters only a reduction in the serum potassium was remarkable.

Adolescent↗
PubMed1984

[Simplified procedure for endoscopic administration of enteral feeding catheters].

Due to the immobilisation of patients in intensive care units or to pathologic alterations in the upper gastrointestinal tract caused by stenosis or anastomosis, the insertion of feeding tubes into the duodenum has been difficult in some cases. For this reason an enteral feeding tube has been developed which can be introduced through the biopsy channel of an endoscope so that it is possible to place the tube under visual control. This method has been used in more than 20 patients; in each case the positioning of the tube and the consecutive nutrition were free of complications. The required material is now commercially available.

Critical Care↗
PubMed1984

[Manometric study on the effect of Hedenstedt's selective proximal vagotomy on the lower esophageal sphincter].

A manometric examination of the oesophagus was carried out before and after selective proximal vagotomy according to Hedenstedt in 20 patients in whom operations were performed at the Dept. of Surgery of the Steglitz Medical Center within the period from 1980 to 1982. The resting pressure of the lower oesophageal sphincter could be shown to be unaltered postoperatively (preoperative median 17,5 mm Hg, postoperative 18 mm Hg, p greater than 0,1 non-significant). Likewise, the other manometric findings were normal and postoperatively unaltered. Thus, it was possible to demonstrate that the modification of the vagotomy according to Hedenstedt has no other effect on oesophageal motility than that already known for other types of selective proximal vagotomy.

Adult↗
PubMed1980

Quantification of alpha-glucosidases along the villus of the small intestine in man. Introduction of a computerized histochemical method.

A method is introduced which enables the two-dimensional detection and analysis of absorbancy-values from continuous dye-deposites with rather low data storage capacity. Applied to histochemical reactions this method is used for kinetic analysis of enzymes along the intestinal villus. Its main part consists of two programs for two dimensional scanning, i.e. along the villus and at right angle from the lumen across the brush-border membrane to the apical cytoplasma. Two further programs serve as prerequisites: the automatical detection of mean values and the description of absorbancy spectra in the tissue section. The measurements are carried out with a MPVII Leitz in connection with a Hewlett Packard 9815 A calculator. The study of alpha-glucosidases of the human small intestine is taken to demonstrate the value of the method. It is shown that a similar Vmax-gradient along the villus can be demonstrated as by microchemical methods. Thus this method enables the description of the kinetic properties of a distinct enzymatic activity in preserved tissue sections on the cellular level and the possible alterations of Vmax and Km in context to the morphological pattern.

Computers↗
PubMedDate not supplied

Subjective distress during continuous enteral alimentation: superiority of silicone rubber to polyurethane.

A small-bore feeding tube of silicone rubber was developed in order to improve the acceptance of enteral feeding. The insertion procedure was facilitated by providing a double guidewire which allows continuous adjustment of tip rigidity. The usefulness of this tube was tested in a short-term and a long-term volunteer study as well as in a prospective follow-up of patients receiving enteral nutrition. The volunteer study showed that the newly developed tube significantly reduced subjective distress (rank value 14) when compared to a conventional tube made of polyurethane (rank value 20). In the patient study, 131 silicone rubber tubes were used in 85 patients who received enteral nutrition for a total period of 2080 days and complained about foreign-body feeling and rhinorrhea in only 3.7% and 0.5% of the days, respectively. The rate of inadvertent removals was relatively low (32%), mainly due to restricted mental status of the patients.

Enteral Nutrition↗
PubMedDate not supplied

Reduction of 24-hour gastric acidity by different dietary regimens: a randomized controlled study in healthy volunteers.

Evidence from animal experiments suggests that intraduodenal infusion of nutrients leads to an inhibition of gastric acid secretion via an enterogastric feedback mechanism. Detailed data are lacking, however, on the difference in circadian gastric acidity between gastric and intraduodenal alimentation in man. We conducted a randomized study in 10 healthy volunteers (5 men, 5 women, age 22-30 yr). From 8:00 am of the first study day until 4:00 pm of the next day, either a standardized normal meal or a liquid polymer diet (Fresubin) was given orally at 8:00 am, noon, and 6:00 pm. In a third experiment, a liquid hydrolysed diet (Survimed OPD) was continuously applied to the duodenum using a portable pump. Daily caloric intake and main nutrient components were comparable in all three diets. From 2:00 pm of the first day until 4:00 pm of the next day, an intragastric pH-metry was performed with a combined glass pH-electrode in the gastric corpus. Median pH-values from predefined time periods (whole day, prandial, interdigestive, nocturnal) were compared between the three groups. The orally applied liquid polymer diet led to a significantly stronger increase in 24-hr and prandial gastric pH than the normal diet. Twenty-four-hr, interdigestive, and nocturnal pH-median values were significantly higher during continuous intraduodenal application of the liquid hydrolysed diet than during the normal diet.

Adult↗