Biomedical subjects
Publications and source records attributed to C F Bernard.
The orally active platinum anti-tumour complex JM216[bis-acetatoamminedichlorocyclohexylamineplatinum(IV)] is at present in stage II clinical trials. A procedure for synthesising the complex labelled with 191Pt or 188Pt at the platinum centre has been developed. The purity (shown by HPLC) is 98% and the specific activity (0.3-0.4 Ci/kg) is enough for in vivo and in vitro studies.
Female rats of the poorly responding, inbred F344 strain were immunized with poly(Glu(52)Lys(33)Tyr(15)) aggregated with methylated bovine serum albumin, and then they were mated. The first and second litters in the F(1) generation and in the F(2) generation showed an enhanced immune response. When poly-lysine was used as the aggregating agent, enhancement occurred in only the first litter of the F(1) generation and in the F(2) generation. In both cases, antigen was transmitted from the immunized female to her offspring, where it localized in the bone marrow and, in a few cases, in the thymus and spleen also. The transplacental passage of antigen is probably the basis for the enhanced antibody response, which is a manifestation of immunological memory.
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