CYTOPATHIC EFFECT OF HUMORAL ANTIBODIES AND SENSITIZED SPLEEN CELLS AGAINST FIBROBLASTS. THE POSSIBLE ROLE PLAYED BY ANTIGENS ACQUIRED FROM CULTURE MEDIA.
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Biomedical subjects
Publications and source records attributed to C F CULLING.
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7-Hydroxychlorpromazine was isolated from liver and urine of psychiatric patients treated with high dosages of chlorpromazine for long periods. These patients developed a purple pigmentation limited to areas of skin exposed to sunlight, as well as opacities of the cornea and lens. Large amounts of melanin were found only in the pigmented skin. It seems likely that a toxic compound is produced by the action of ultraviolet light on a 7-hydroxylated chlorpromazine derivative deposited in skin, cornea, and lens, and that this in turn leads to excessive melanin production and eye changes.
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