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Biomedical subjects

C F Claussen

Publications and source records attributed to C F Claussen.

At least 19 recordsLinked to original sources
PubMed1992

Plastic properties of the vestibulo-ocular reflex in olivo-ponto-cerebellar atrophy.

Disorders in vestibulo-ocular functions were studied in 4 patients with olivo-ponto-cerebellar atrophy (OPCA). The phenomenon of habituation, considered as a plastic property of the vestibulo-ocular reflex (VOR), was explored with a behavioural paradigm in these patients. When subjected to the habituation paradigm all patients presented a modified response opposite to that observed in normal subjects. The role played by the cerebellum in relation to VOR plasticity--well known in different experimental models--is analyzed. The hypothesis of a modification of the cerebellum's inhibitory action on vestibular nuclei neurons is put forward to explain the inversion of the VOR habituation phenomenon in these patients.

Adult↗
PubMed1991

Cranio-corpo-graphy. A neurootological screening test.

Cranio-corpo-graphy affords a photographic representation of the patient's "radar-like" movement patterns as he performs the standing (Unterberger, Fukuda) and stepping (Romberg) tests. Of the various parameters used for analysis, a wide angular deviation, i.e., where the patient deflects more than circa 60 degrees away from the sagittal axis, is taken to signify a peripheral dysfunction, usually involving the side of deviation. In addition, broad lateral sway values and standing tests sways suggest a central pathology. In this study, three data banks were created. One consisting of 500 patients tested in our department over the last ten years, all showing a normal cranio-corpo-graphic pattern; the second made up of 500 patients showing a clear peripheral pattern, i.e., abnormal angular deviation with normal sway values and the third (650 patients) with a typical central disturbance, i.e. a broad lateral sway. These groups were then submitted to a detailed statistical analysis.

Adult↗
PubMed1989

The treatment of minocycline-induced brainstem vertigo by the combined administration of piracetam and ergotoxin.

Two randomized studies to test the efficacy of a combination of Piracetam and Ergotoxin on the destabilized brainstem are reported. In the first study, a pharmacological model using Minocycline is employed. A follow-up clinical study analysed the effect of the preparation in 5 patients suffering from vertigo and other related complaints. It was seen that there was a significant improvement in the nystagmus profiles of the pharmacological model volunteers. Similarly, the patient group showed a marked improvement in symptoms, and in orientation capability as tested by Cranio-Corpo-Graphy.

Adult↗
PubMed1989

A computer analysis of typical CCG patterns in 1,021 neuro-otological patients.

A set of 1,021 patients who were investigated at our Department over the last few years was investigated in this study. Each patient underwent Cranio-Corpo-Graphy, and other related investigations. The patients' CCG's were quantified using a specially developed computer scanning method, and a computerized spreadsheet databank was thus created. Also included in the study were their clinical profiles, as charted using the NODEC III questionnaire. The isolation and comparison of various data subsets enables us to draw broad correlations between clinical and CCG findings, and permits us to establish 'normal values' for various parameters. It is seen that cranio-corpography is a reliable screening method for the topodiagnosis of vertigo.

Adult↗
PubMed1988

[Antivertiginous action of vitamin B 6 on experimental minocycline-induced vertigo in man].

By means of a former investigation it has been proved equilibriometrically that the application of 7 X 100 mg minocycline may induce a central equilibrium dysregulation of the brainstem type. It was the purpose of this study to further assure that the minocycline induced brainstem vertigo is due to a destabilization of a supervisory gamma-aminobutyric acid (GABA)ergic loop from the archeocerebellum upon the pontomedullary vestibular regulating pathways. As it is pharmacologically known that pyridoxine is essential for the synthesis of GABA, an inhibitory CNS neurotransmitter, 2 separate double blind trials on 20 healthy young persons each were carried out after the intake of 7 X 100 mg minocycline during 3 days with and without 7 X 40 mg pyridoxine simultaneously. These trials were checked against an additional placebo or initial non drug investigation. In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only. However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs from the monaural and the binaural vestibular ocular tests as well as the vestibular spinal signs from the craniocorpography recordings of the stepping and the standing procedures were remarkably reduced. There were no statistical differences between the initial or placebo trials versus the trials with a combination of minocycline with vitamin B 6. The same holds for the vestibular vegetative reactions, measured by the simultaneous electrocardiography during the vestibular tests. All the equilibriometric tests applied showed a significant destabilization under the influence of a pure minocycline loading.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

[Equilibriometric measurements of central vestibular dysregulation following administration of minocycline].

An equilibriometric study has been performed on 20 healthy young women before and after the intake of 7 times 100 mg minocycline during 3 days. A systematic neurootological equilibriometry was performed analyzing the vestibular ocular, the vestibular spinal, the retino-ocular and the spontaneous nystagmus pathways. The results demonstrate that the tetracycline minocycline provokes a ponto-medullary liberation of the central vestibular regulating mechanisms. The central vestibular disinhibition could be exhibited by the monaurally elicited vestibular ocular nystagmus as well as by the radar image like cranio-corpography recordings of the head and body movements during a vestibular spinal stepping test. In parallel with these findings the participants of the study increasingly complained about vertigo of the rocking type, instability, malaise and wretching. Thus, the untoward side effects of a tetracycline like minocycline which is a frequent complaint of the patients, appears to be due to a central disinhibition of the vestibular equilibrium regulating mechanisms.

Adult↗
PubMed1986

[Diagnostic and practical value of craniocorpography in vertiginous syndromes].

Vertigo or dizziness and nausea are the subjective symptoms characteristic of vertiginous syndromes; nystagmus and oscillations of the head and body are the objective signs. Craniocorpography is a method for recording and measuring these oscillations rapidly and inexpensively. It provides easier diagnosis, follow up and measurement of a double-blind therapeutic effectiveness. In the trial author has demonstrated the beneficial effects of Ginkgo biloba Extract in vertiginous syndromes without obvious anatomical localisation.

Gait↗
PubMed1976

[The clinical olfactogram (author's transl)].

Clinical olfactometry is described in which patients are exposed to supraliminal stimuli of well-known types of odors. The results are then placed on a graded recognition scale as a polar coordinate system. Each clinical odor tested produces a typical recognition pattern which can easily be interpreted. Typical patterns for different conditions involving olfaction exist, and include euosmia, sensory anosmia, and respiratory anosmia. A simplified U-tube rhinomanometer can also be used, and data graphed on the same chart as for olfactometry. The procedure as described has been successfully tested on several hundred patients and controls.

Humans↗