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Biomedical subjects

C F Grindle

Publications and source records attributed to C F Grindle.

7 recordsLinked to original sources
PubMed1988

Four and one-half year study of the relationship between one-piece encircling loop polymethylmethacrylate lenses and retinal detachment.

Prospective studies in this series of 2,802 patients have shown that the incidence of retinal detachment is significantly reduced with an intact posterior capsule. Furthermore, if a capsulotomy has to be performed, the data from this series suggest that it is preferable not to open the capsule at the time of surgery but at a later time, when the IOL optic has fixed to the posterior capsule. A subsequent YAG capsulotomy will not disrupt this apposition and will not alter the barrier protection of aqueous movement to the vitreous. This effect can be achieved with a continuous ridge on the posterior surface of the lens or, alternatively, with a convex posterior IOL surface.

Adult↗
PubMed1977

Plasma exchange in the long-term management of Waldenström's macroglobulinemia.

Two patients with Waldenström's macroglobulinemia (WM), which had become resistant to cytotoxic drugs, were treated for features of the hyperviscosity syndrome by repeated plasma exchange with the continuous-flow blood-cell separator over periods of 36 and 28 months, respectively. After four initial weekly plasma exchanges the procedure was carried out every 4 to 6 weeks and both patients tolerated it well. Relative viscosity of the serum was maintained within the normal range in one patient, and both patients remained free of symptoms of the hyperviscosity syndrome. The results suggest that treatment of WM by long-term "maintenance" plasma exchange alone should be considered in any patient with complications due to chemotherapy or whose disease fails to respond to chemotherapy.

Aged↗
PubMed1977

Ocular involvement in leukaemia. Report of three cases.

Three patients with treated acute lymphoblastic leukaemia acquired visual symptoms believed to be caused by ocular infiltration by malignant cells. All three patients had other evidence of systemic disease including bone-marrow involvement at the time. One patient had a previous history of meningeal leukaemia and none had received "prophylactic" cranial irradiation. The ophthalmoscopic appearances were similar in each case and were thought to have been caused by obstruction of axoplasmic flow associated with infiltration of the optic nerve by neoplastic cells. The three patients were treated by local irradiation and two also received intrathecal chemotherapy. Response to treatment was variable but the use of radiotherapy combined with intrathecal cytoxic drugs is probably the best available approach.

Adult↗