Phenylketonuria: a diagnosis that affects the entire family.
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Biomedical subjects
Publications and source records attributed to C F Johnson.
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We reported the occurrence of congenital and neurological abnormalities in 150 children with phenylketonuria (PKU) age 1 year or older, who have been treated with a restricted phenylalanine diet, according to the protocol used in a nation-wide longitudinal collaborative study of children treated for PKU. The overall occurrence (9.3%) of congenital anomalies was not significantly different from that of a general population, except for an apparent increased incidence of pyloric stenosis. None of the subjects had a persistent major neurological defect.
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The identification of Mycobacterium tuberculosis organisms is insensitive. This in vitro investigation compares the sensitivity of Ziehl-Neelsen and fluorochrome staining techniques after two and ten hours of incubation with standard culture techniques. The culture methods were persistently more sensitive than the stain techniques. Both stain techniques were of equal sensitivity. Ten hours incubation reduces the sensitivity of the staining techniques but does not alter the sensitivity of the culture methods.
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