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Biomedical subjects

C F Kiire

Publications and source records attributed to C F Kiire.

At least 19 recordsLinked to original sources
PubMed1992

Value of the history and stool occult blood test in selection of patients for upper endoscopy in Zimbabwe.

Patients with abdominal pain and no definite diagnosis referred for endoscopy were studied to define discriminating features in the history, and the value of a stool occult blood test, in predicting the presence of upper gastrointestinal disease. Endoscopy was performed in 116 patients; pathology was seen in 32 (duodenal ulcer 17, gastric carcinoma 4, gastric ulcer 3, miscellaneous 8) and no pathology was seen in 84 patients. Features that predicted upper gastrointestinal pathology were, in descending order of rank: a positive pointing sign, a positive stool Fecult test, a history of vomiting, loss of weight, and alcohol intake. Using these discriminating features together it was possible to correctly predict 95% of patients with abnormal endoscopy and 82% of patients with a normal endoscopy. The history and the stool occult blood test are useful predictors of the presence of upper gastrointestinal pathology and may aid rational selection of patients for endoscopy.

Endoscopy, Gastrointestinal↗
PubMed1990

Hepatitis B infection in sub-Saharan Africa. The African Regional Study Group.

Hepatitis B virus (HBV) infection and its sequelae are extremely common in sub-Saharan Africa. The overall hepatitis B surface antigen (HBsAg) carrier rate in the general population is 5-20%, which is amongst the highest in the world. Although perinatal infection occurs with an incidence of 1-5%, the predominant form of transition is horizontal among infants and young children; most infections are acquired between 6 months and the pre-school age (5-6 years). Thus, the traditional concept of 'high-risk groups' is of limited importance in Africa and all children should be regarded as being at risk. Hepatitis B-associated hepatocellular carcinoma is probably the most common tumour affecting males in sub-Saharan Africa, with Mozambique having the highest incidence rate of 103.8 per 100,000 males. Cost-benefit analysis shows that, in sub-Saharan Africa, the most effective way of controlling hepatitis B infection is through mass neonatal vaccination programmes integrated within the Expanded Programme on Immunization without prior testing for HBV markers.

Adolescent↗
PubMed1989

Controlled trial of propranolol to prevent recurrent variceal bleeding in patients with non-cirrhotic portal fibrosis.

Fifty patients with non-cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in doses that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the placebo group were free from recurrent gastrointestinal bleeding (p less than 0.0001). Giving continuous oral propranolol treatment is therefore effective in preventing recurrent upper gastrointestinal bleeding in patients with non-cirrhotic portal fibrosis.

Administration, Oral↗
PubMed1987

Protein losing enteropathy: an unusual presentation of intestinal schistosomiasis.

A patient presenting with features suggestive of malabsorption syndrome is described who had florid intestinal schistosomiasis on peroral biopsy of the jejunum. Liver biopsy and rectal biopsy also revealed schistosomal ova. Biochemical studies revealed severe hypoproteinaemia and hypoalbuminaemia, caused by a protein losing enteropathy. This is the first reported case of protein losing enteropathy caused by intestinal schistosomiasis.

Adolescent↗
PubMed1986

Hypoglycaemia and cerebral malaria.

A patient with severe hypoglycaemia complicating cerebral malaria is reported. No other recognized cause of hypoglycaemia was detected during life or at autopsy. This case adds to the existing evidence that, through several possible mechanisms, cerebral malaria can give rise to life-threatening hypoglycaemia.

Brain Diseases↗
PubMed1986

Typhoid colitis.

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Adult↗