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Biomedical subjects

C F Koopmann

Publications and source records attributed to C F Koopmann.

At least 19 recordsLinked to original sources
PubMed1995

Neonatal choristoma of the tongue containing glial tissue: diagnosis and surgical considerations.

There are only six case reports documenting the presence of glial tissue in the tongue. Because of the small number of cases, the presentation and biologic behavior of these lesions is poorly characterized. We present the case of a 10-day-old male infant who arrived at the University of Michigan Medical Center with a history of positional dyspnea, with resultant cyanosis and bradycardia, dysphagia, and a mass at the base of the tongue. Histopathologically, this lesion was initially labeled as a hamartoma, but was ultimately defined as a choristoma based on the exclusive presentation of glial tissue in the specimen. This paper will discuss the presentation, diagnostic evaluation, and therapeutic management of this case. In addition, the role of intraoperative electrodiagnostic monitoring to preserve neuromuscular function will be addressed.

Choristoma↗
PubMed1995

Cutaneous wound healing. An overview.

This article is a general discussion of the mechanisms of soft-tissue wound healing with an emphasis on tissue. The overall phases of cutaneous wound healing and their influencing factors are described as are concepts for managing skin incisions to achieve a more optimal scar appearance.

Humans↗
PubMed1993

Radiation therapy as an alternative to surgery in the management of intracranial juvenile nasopharyngeal angiofibroma.

Juvenile nasopharyngeal angiofibroma is a benign, vascular tumor which typically presents in adolescent males. Although surgical resection is usually recommended for the management of this tumor, external beam radiation therapy has also been advocated in the literature. We report three cases of large juvenile nasopharyngeal angiofibromas with extensive intracranial extension primarily managed with external beam radiation therapy. Although there was not complete resolution of the tumors, there was significant alleviation of symptomatology with no serious side effects from the radiation therapy. Based on these cases, we feel that external beam radiation therapy in the management of extensive juvenile nasopharyngeal angiofibromas with intracranial extension is warranted in certain select cases.

Adolescent↗
PubMed1992

Flutamide-induced regression of angiofibroma.

Juvenile nasopharyngeal angiofibroma (JNA) appears to be an endocrine-responsive tumor. This concept was tested in five young men with JNA by treating them with a testosterone receptor blocker (flutamide) for 6 weeks preoperatively. Tumor size was evaluated by axial computed tomography both before and after flutamide therapy. Four of the five patients had an average tumor shrinkage of 44%. The patients tolerated the drug well, and the serum testosterone levels 2 or more years posttherapy were normal. This pilot study demonstrate that preoperative hormonal pharmacoreduction of JNA is a feasible adjunct to surgical therapy that offers the possibility of reduced blood loss. However, the authors believe that a formal clinical trial of this treatment approach is warranted and should be done before widespread adoption of this agent.

Adolescent↗
PubMed1991

Otolaryngologic (head and neck) problems in the elderly.

This article is designed to give the reader an appreciation of some of the more common or important facets of the management of head and neck disorders in the elderly patient. Readers are referred to the references for more detailed descriptions of the topics.

Aged↗
PubMed1991

Intracranial complications of paranasal sinusitis: a combined institutional review.

Intracranial complications of paranasal sinusitis constitute true surgical and medical emergencies. The charts of all patients (n = 649) admitted for acute or chronic sinusitis to the University of Minnesota Hospital and to the University of Michigan Medical Center during a 13-year period (1975 to 1988) were retrospectively reviewed to determine the incidence of complications. The clinical presentation, bacteriology, involved sinuses, influencing host factors, white blood cell count on presentation, length of hospitalization, and postinterventional complications are presented. Twenty-four patients with intracranial complications from paranasal sinusitis are studied for an incidence of 3.7%. Aggressive medical and semi-emergent surgical intervention are required to prevent excessive morbidity and/or mortality. Intracranial complications included subdural empyema, frontal lobe abscesses, intrahemispheric abscesses, cavernous and superior sagittal sinus thrombosis, and osteomyelitis.

Adolescent↗
PubMed1990

Facial nerve paresis as the presenting symptom of leukemia.

Leukemic involvement of the temporal bone is not uncommon and may present in a variety of ways including auricular or external canal skin lesions, red or thick tympanic membrane, middle ear effusions, otitis media, hearing loss or mastoiditis. Symptomatic facial nerve involvement, on the other hand, is extremely unusual. We discuss a pediatric patient whose sudden onset facial nerve paresis was the presenting symptom that led to her diagnosis of leukemia. At the time of mastoidectomy, a granulocytic sarcoma or chloroma was noted to be overlying the VIIth nerve.

Child↗
PubMed1990

Juvenile myasthenia gravis: an unusual presentation.

Myasthenia gravis is a disease characterized by muscular weakness and fatigability which afflicts 2-10 patients per 100,000 with 20% of cases presenting in childhood. Muscles innervated by cranial nerves are frequently involved with ptosis and diplopia being the most frequent presenting complaints. We review the literature and report a case of a 20-month-old infant presenting with inspiratory stridor and cyanosis, resembling foreign body aspiration.

Bronchi↗
PubMed1990

The use of biopsy in the evaluation of pediatric nasopharyngeal masses.

Pediatric nasopharyngeal tumors are rare, and few clinicians possess more than anecdotal experience. The differential diagnosis includes a diverse group of benign and malignant tumors, but can be narrowed further based on the clinical and radiographic appearance of the mass. Nasopharyngeal angiofibroma has such characteristic angiographic and CT imaging that many authors suggest biopsy is not essential in the evaluation of this lesion. We present a case of a pediatric nasopharyngeal neoplasm with angiographic, CT, and clinical findings consistent with angiofibroma. We then discuss the preoperative evaluation of, operative approach to, and postoperative staging and treatment of the biopsy-proven embryonal rhabdomyosarcoma. A review of the literature pertinent to this case is presented, and recommendations made concerning biopsy of lesions resembling juvenile nasopharyngeal angiofibroma. We believe this report reaffirms the use of histologic study whenever possible, in addition to radiographic imaging, in the diagnosis of pediatric nasopharyngeal masses.

Biopsy↗
PubMed1990

Sleep apnea--an historical perspective.

In this article the authors have attempted to give the reader a brief overview of some of the development of recognition of obstructive sleep disorders and early aspects of their surgical therapy. They have avoided detailed descriptions of radiographic and other diagnostic measures, since many of these are summarized in other articles.

History, 19th Century↗
PubMed1990

Surgical management of obstructive sleep apnea.

The authors have reviewed the surgical management of patients with OSA. They have emphasized not only surgical techniques but also the method of preoperative evaluation of the patients and have presented some considerations in the postoperative management of patients in an attempt to avoid catastrophic results. As our diagnostic techniques improve, we should have fewer problems with the determination of the amount of tissue to remove and also the selection of the appropriate procedure. The advent of flexible laryngoscopy, cineradiography, and cine CT may indeed improve our diagnostic and therapeutic capabilities.

Adult↗
PubMed1988

The anterior cricoid split. Clinical experience with extended indications.

A recommended approach to postextubation infant subglottic stenosis secondary to subglottic edema employs the recently described anterior cricoid split (ACS) procedure. This technique provides an expanded subglottic airway with minimal paratracheal dissection and does not require concomitant tracheotomy. We applied this procedure in managing extubation difficulty in pediatric as well as neonatal patients. Five of ten patients in our series did not fulfill the traditional criteria for ACS. Relief of stridor and avoidance of tracheotomy were accomplished in nine of ten patients. One patient in whom mechanical ventilation was reinstituted developed an interesting complication. In properly selected infants with subglottic airway compromise, the ACS appears to be an effective adjunct in facilitating extubation.

Child, Preschool↗
PubMed1988

Arthrogryposis multiplex congenita: otolaryngologic diagnosis and management.

Arthrogryposis multiplex congenita (AMC) is an uncommon congenital disorder characterized by multiple fixed joint deformities and non-progressive neuromuscular dysfunction. A small fraction of these infants will present with otolaryngologic problems resulting from cranial nerve weakness, muscle dysplasia, or structural dysharmony of the head and neck. The charts of 50 patients with AMC were reviewed to determine the incidence of these findings. A summary of the literature is presented discussing the etiology, pathophysiology, diagnosis and management of this interesting clinical problem.

Arthrogryposis↗
PubMed1988

The "Pinocchio" nasal deformity--hemangioma vs. angiolipoma: esthetic correction and etiology.

The author presents the first reported case of a nasal angiolipoma presenting as "Pinocchio" nasal tip deformity. The two types of angiolipomas (infiltrating and non-infiltrating) are discussed as are two surgical approaches to this deformity. The author feels that the external rhinoplasty technique is an excellent way to approach this problem, especially in patients who are suffering severe emotional stress due to peer pressure.

Child↗
PubMed1987

Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma.

Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant processes is difficult despite extensive clinical and histopathologic evaluation. The need for new techniques for rapid diagnosis has important therapeutic implications. Using an extensive panel of T- and B-cell monoclonal antibodies the authors describe a patient with clinically and pathologically typical LMG demonstrating an "activated" T-cell phenotype with a "novel" pattern characteristic of peripheral T-cell lymphoma, strongly implying that some cases of LMG are more closely related to neoplastic T-cell lymphoproliferative disorders than to inflammatory conditions. Further studies using these immunotyping techniques may help clarify the pathogenesis of LMG, and may uncover specific diagnostic and prognostic phenotypic patterns.

Adult↗
PubMed1987

Non-organic stridor in children.

A 4.75-year-old male presented with several episodes of expiratory stridor leading, on one occasion, to a respiratory arrest and intubation. A detailed evaluation emphasizing physiological and anatomical studies revealed no organic basis for the patient's upper airway obstruction. Emphasis is placed on one method found to be helpful in the differentiation of an organic versus a psychogenic type of respiratory disorder. Recognition of functional airway obstruction in children may prevent inappropriate therapy and allow proper psychiatric intervention.

Adjustment Disorders↗