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Biomedical subjects

C F Lake

Publications and source records attributed to C F Lake.

7 recordsLinked to original sources
PubMed1977

Management of epistaxis in hereditary hemorrhagic telangiectasia. Review of 80 cases.

Intranasal dermoplasty and estrogen therapy have been shown to be the most effective means of managing epistaxis in patients with hereditary hemorrhagic telangiectasia. In a series of 80 patients studied, the most effective treatment was by intranasal dermoplasty; of 22 patients so treated, 14 had improvement for more than six months after surgery and six had improvement for one to six months. Regrafting for recurrent epistaxis was successful in four of five patients (improvement for more than six months). Estrogen was administered for systemic effect to 16 patients and produced improvement of more than six months' duration in eight and of one to six months' duration in three. Other forms of management were less effective for the prolonged control of epistaxis.

Administration, Topical↗
PubMed1976

Thin rubber sheeting in frontal sinus surgery: animal and clinical studies.

Closure of the nasofrontal communication is the most common cause of failure of nonobliterative external of nonobliterative external frontal sinus operations for chronic sinus disease. To determine whether silicone rubber sheeting or tubing might prevent closure, we designed animal experiments and conducted a clinical study. We enlarged the nasofrontal duct in dogs, inserted silicone rubber tubing or sheeting and assessed ductal patency grossly and microscopically. The tubes prevented epithelization and failed to prevent local osteoblastic reaction, fibroplasia, and scar formation. In contrast, sheeting permitted rapid mucosal regeneration, less osteoblastic activity, and less fibrosis. Our 16 patients with chronic sinus disease underwent a modified Lynch operation, with enlargement of the nasofrontal duct and stenting with rubber tubes or sheeting. The sheeting provided the best long-term result. In our experience, it raised the success rate of the classic Lynch external operation.

Adolescent↗
PubMed1975

Symposium. ENT for nonspecialists. Problems of the septal areas.

The problems of the nasal septum can be best discussed by dividing the septum into five areas. Each area of the septum has common causes of nasal obstruction that are specifically pertinent. The principles of conservative septal pyramid surgery are also important considerations within each area.

Humans↗